Journal of the American Society for Mass Spectrometry

, Volume 15, Issue 9, pp 1300–1314

Mass spectral fragmentation reactions of angiotensin-converting enzyme (ACE) inhibitors


DOI: 10.1016/j.jasms.2004.05.010

Cite this article as:
Burinsky, D.J. & Sides, S.L. J Am Soc Mass Spectrom (2004) 15: 1300. doi:10.1016/j.jasms.2004.05.010


A variety of mass spectrometric techniques have been employed in the study of a series of structurally similar compounds used in the treatment of hypertension. The compounds, known collectively as angiotensin-converting enzyme (ACE) inhibitors, all share the amino acid residue proline or some variant thereof, as a common structural element. The gas phase fragmentation behavior of these compounds has been explored systematically using various instruments and techniques. An interesting dissociation process (rearrangement) unique to one of the compounds, lisinopril, has been investigated using isotopic labeling experiments and exact mass measurements. The general nature of the process has been probed through both the positive and negative ion analyses of fourteen related compounds exhibiting structural homology.

Copyright information

© American Society for Mass Spectrometry 2004

Authors and Affiliations

  1. 1.Chemical Development DivisionGlaxoSmithKline, Five Moore DriveResearch Triangle ParkUSA

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