Meerwein reaction of phosphonium ions with epoxides and thioepoxides in the gas phase

  • Eduardo C. Meurer
  • Hao Chen
  • Leah S. Riter
  • R. Graham Cooks
  • Marcos N. Eberlin
Articles

Abstract

Phosphonium ions are shown to undergo a gas-phase Meerwein reaction in which epoxides (or thioepoxides) undergo three-to-five-membered ring expansion to yield dioxaphospholanium (or oxathiophospholanium) ion products. When the association reaction is followed by collision-induced dissociation (CID), the oxirane (or thiirane) is eliminated, making this ion molecule reaction/CID sequence a good method of net oxygen-by-sulfur replacement in the phosphonium ions. This replacement results in a characteristic mass shift of 16 units and provides evidence for the cyclic nature of the gas-phase Meerwein product ions, while improving selectivity for phosphonium ion detection. This reaction sequence also constitutes a gas-phase route to convert phosphonium ions into their sulfur analogs. Phosphonium and related ions are important targets since they are commonly and readily formed in mass spectrometric analysis upon dissociative electron ionization of organophosphorous esters. The Meerwein reaction should provide a new and very useful method of recognizing compounds that yield these ions, which includes a number of chemical warfare agents. The Meerwein reaction proceeds by phosphonium ion addition to the sulfur or oxygen center, followed by intramolecular nucleophilic attack with ring expansion to yield the 1,3,2-dioxaphospholanium or 1,3,2-oxathiophospholanium ion. Product ion structures were investigated by CID tandem mass spectrometry (MS2) experiments and corroborated by DFT/HF calculations.

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Copyright information

© American Society for Mass Spectrometry 2004

Authors and Affiliations

  • Eduardo C. Meurer
    • 1
  • Hao Chen
    • 1
  • Leah S. Riter
    • 1
  • R. Graham Cooks
    • 1
  • Marcos N. Eberlin
    • 2
  1. 1.Department of ChemistryPurdue UniversityWest LafayetteUSA
  2. 2.Institute of ChemistryState University of Campinas, UNICAMP, SPBrazil

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