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Bulletin of Mathematical Biology

, Volume 67, Issue 1, pp 15–32 | Cite as

Models for the dynamics and order of immunoglobulin isotype switching

  • Barak Yaish
  • Ramit Mehr
Article

Abstract

Experiments show that class switch recombination (CSR) depends on the number of divisions that the cell has performed rather than on the time since stimulation. Using computer simulations of CSR dynamics in B cell populations, we addressed the following questions. How does the probability of CSR depend on the number of divisions that a cell has performed? How does the cell decide which isotype to switch to? Does this decision depend on the distance between the genes of the pre-switch and the post-switch isotype? Our results indicate that post-switch isotype choice may be determined indirectly by the probabilities of division (which is fixed) and of switching per division (which increases as a function of the number of divisions that a cell performs), and more directly by a bias in the choice of the post-switch C gene segment towards those proximal to the pre-switch C gene.

Keywords

Mathematical Biology CD40 Ligand Class Switch Recombination Isotype Switching Activation Induce Cytidine Deaminase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

CSR

class switch recombination

AID

activation-induced cytidine deaminase

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Copyright information

© Society for Mathematical Biology 2005

Authors and Affiliations

  1. 1.Faculty of Life SciencesBar-Ilan UniversityRamat-GanIsrael

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