Effect of electrospray needle voltage on electroosmotic flow in capillary electrophoresis-mass spectrometry

  • Iulia M. Lazar
  • Milton L. LeeEmail author
Short Communication


The effect of the electrospray ionization (ESI) needle voltage on the electroosmotic flow (EOF) in capillary electrophoresis (CE)-mass spectrometry (MS) was investigated. The radial electric field that penetrates across the CE capillary wall imposed by the ESI needle voltage modifies the typical EOF. This effect was investigated for buffers commonly used in CE-MS. Variations as high as ±30% were observed.


Capillary Electrophoresis Electroosmotic Flow Stainless Steel Needle Radial Electric Field Radial Field 
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Copyright information

© American Society for Mass Spectrometry 1999

Authors and Affiliations

  1. 1.Department of Chemistry and BiochemistryBrigham Young UniversityProvoUSA

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