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Analysis of coumarins by micro high-performance liquid chromatography-mass spectrometry with a particle beam interface

  • Achille Cappiello
  • Giorgio Famiglini
  • Filippo Mangani
  • Bruno Tirillini
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Abstract

Coumarins are a large group of compounds that are naturally present in plant tissues and that exhibit a wide range of pharmacological properties. Analytical methods based on chromatographic techniques and conventional detectors are inadequate to accurately analyze coumarins in complex matrices such as plant extracts. In this article a new method based on a modified particle beam liquid chromatography-mass spectrometry interface is described. The method allows specific and accurate determination of several coumarins in biological matrices. An application regarding the analysis of 18 coumarins in the extract of Smyrnium perfoliatum L. is also reported.

Keywords

Coumarin Scopoletin Mobile Phase Flow Rate Imperatorin Xanthotoxin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© American Society for Mass Spectrometry 1995

Authors and Affiliations

  • Achille Cappiello
    • 1
  • Giorgio Famiglini
    • 1
  • Filippo Mangani
    • 1
  • Bruno Tirillini
    • 2
  1. 1.Istituto di Scienze ChimicheUniversità di UrbinoUrbinoItaly
  2. 2.Istituto di Botanica e Orto BotanicoUniversità di UrbinoUrbinoItaly

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