A simple approach for coupling liquid chromatography and electron ionization mass spectrometry

  • Achille Cappiello
  • Giorgio Famiglini
  • Filippo Mangani
  • Pierangela Palma


A miniaturized, aerosol based interface for directly coupling a liquid chromatograph with a mass spectrometer is presented. The interface is entirely within the electron ionization (EI) source of the mass spectrometer and no additional, external devices are needed. This simple and effective approach exploits micro-flow nebulization technology providing a new interface suitable for a variety of applications of environmental and biological interest. The new interface provides necessary linearity, ruggedness, sensitivity, and reproducibility of response for trace level analysis, and readily interpretable mass spectra for unambiguous identification of unknown compounds of small to medium molecular weight.


High Performance Liquid Chromatography Electron Ionization Electron Ionization Mass Spectrometry Mobile Phase Flow Rate Propanil 
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Copyright information

© American Society for Mass Spectrometry 2002

Authors and Affiliations

  • Achille Cappiello
    • 1
  • Giorgio Famiglini
    • 1
  • Filippo Mangani
    • 1
  • Pierangela Palma
    • 1
  1. 1.Istituto di Scienze ChimicheUniversità di UrbinoUrbinoItaly

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