A dynamic ion cooling technique for FTICR mass spectrometry

  • Michael V. Gorshkov
  • Christophe D. Masselon
  • Gordon A. Anderson
  • Harold R. Udseth
  • Richard Harkewicz
  • Richard D. Smith
Short Communication
Received:
Revised:
Accepted:

Abstract

A fast dynamic ion cooling technique based upon the adiabatic invariant phenomenon for Fourier transform ion cyclotron resonance mass spectrometry (FTICR) is presented. The method cools ions in the FTICR trap more efficiently, within a few hundred milliseconds without the use of a buffer gas, and results in a substantial signal enhancement. All performance aspects of the FTICR spectrum, e.g., peak intensities, mass resolution, and mass accuracy, improve significantly compared with cooling based on ion—ion interactions. The method may be useful in biological applications of FTICR, such as in proteomic studies involving extended on-line liquid chromatography (LC) separations, in which both the duty cycle and mass accuracy are crucially important.

Keywords

Melittin Trapping Potential Charge State Distribution Pacific Northwest National Laboratory Adiabatic Invariance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© American Society for Mass Spectrometry 2001

Authors and Affiliations

  • Michael V. Gorshkov
    • 1
  • Christophe D. Masselon
    • 1
  • Gordon A. Anderson
    • 1
  • Harold R. Udseth
    • 1
  • Richard Harkewicz
    • 1
  • Richard D. Smith
    • 1
  1. 1.Environmental Molecular Sciences LaboratoryPacific Northwest National Laboratory, MS K8-98RichlandUSA

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