Investigations of gas-phase lithium-peptide adducts: Tandem. mass spectrometry and semiempirical studies
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Tandem mass spectrometry using a hybrid mass spectrometer of BEqQ geometry was used to investigate the gas-phase formation of the [An+ Li − H)+ ion from lithium-peptide adducts. High resolution mass measurements as well as precursor and product ion scans of five peptides indicate that one source of [An+ Li − H) arises from [An+ Li]+. Semiempirical calculations (MNOO) and metastable ion decomposition studies of the peptide Gly-Gly-Gly show that the lithium ion prefers to coordinate to the three internal carbonyls of the neutral molecule to give a species that is energetically more stable than the lithiated zwitterion by 305 kJ/mol. Theoretical and experimental evidence suggest that the monolithiated precursor ion population may be a distribution of structural isomers. (J Am Soc Mass Spectrom 1990, 1, 473-480)
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- 7.Clark, T. A Handbook of Computational Chemistry; John Wiley: New York, 1985.Google Scholar
- 8.Meulemans, P. R.; Piret, P.; Van Meerssche, M. Acta. Cryst. 1971, B27, 1187.Google Scholar
- 14.Thorne, G. C.. Ballard. K. D.; Gaskell, S. T. J. Am. Soc. Mass Spectrom. 1990, in press.Google Scholar