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Anthraquinone/activated carbon electrochemical sensor and its application in acetaminophen analysis

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Abstract

Acetaminophen (AC) can inhibit the synthesis of prostaglandins in the body, and has antipyretic and analgesic effects. In this paper, a two-step microwave impregnation method was used to prepare anthraquinone (AQ)-doped carbon composite, which were applied to the surface modification of glassy carbon electrodes (GCE) for the determination of acetaminophen (AC) using differential pulse voltammetry (DPV). The composites were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), Raman and Fourier infrared spectroscopy (FT-IR). The results showed that anthraquinone was successfully modified on the surface of activated carbon. The peak current of AC increased with its concentration in the range of 0.1 μM to 700 μM (R2 = 0.998) and a detection limit of 0.05 μM was obtained with 20%AQ doped carbon electrochemical sensor (20%AQ-C/GCE). Electrochemical Impedance Spectroscopy (EIS) test results indicated that the charge transfer resistance (Rct) of 20%AQ-C/GCE is only the one-fourth of that of bare GCE. The proposed 20%AQ-C/GCE sensor has good stability, reproducibility and selectivity for the detection of AC. The sensor is also suitable for the detection of real samples, indicating its good practicality.

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The datasets generated during and/or analyzed during the current study are available from the corresponding author upon reasonable request.

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Acknowledgements

This work was supported by the Wuhan Institute of Technology Graduate Education Innovation Fund (CX2022027), the financial supports from the Opening Research Fund of Hubei Key Laboratory for Processing and Application of Catalytic Materials and the Natural Science Foundation of Hubei Province (Grant No. 2016CFA079)

Funding

Natural Science Foundation of Hubei Province, 2016CFA079, Qifeng Tian.

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Authors and Affiliations

  1. Key Laboratory of Green Chemical Process of Ministry of Education & Hubei Key Laboratory of Novel Reactor and Green Chemical Technology, Wuhan Institute of Technology, Wuhan, 430205, People’s Republic of China

    Cailing Zhong, Yuwen Chen, Yixuan Zheng, Qifeng Tian & Yichang Chen

  2. School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, 430205, People’s Republic of China

    Cailing Zhong, Yuwen Chen, Yixuan Zheng, Qifeng Tian & Yichang Chen

  3. Hubei Key Laboratory for Processing and Application of Catalytic Materials, College of Chemistry and Chemical Engineering, Huanggang Normal University, Huanggang, 438000, People’s Republic of China

    Mingjiang Xie & Zhengfang Tian

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  1. Cailing Zhong
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Correspondence to Qifeng Tian or Zhengfang Tian.

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Zhong, C., Chen, Y., Zheng, Y. et al. Anthraquinone/activated carbon electrochemical sensor and its application in acetaminophen analysis. ANAL. SCI. (2024). https://doi.org/10.1007/s44211-024-00537-3

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