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Development of a cost-effective laser diode-induced fluorescence detection instrument for cyanide detection

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Abstract

Cyanide is highly toxic to humans and the environment. It is very important to develop an on-site system for the quantitative analysis of cyanide with high sensitivity and reliability. In this study, we developed a cyanide detection system based on the reaction of vaporized cyanide on a glass-fiber filter soaked in a mixture of naphthalene-2,3-dicarboxaldehyde (NDA)-taurine-borate solution. Although the reaction product was stable for at least 3 days at room temperature, the reaction product on the strip was quickly quenched within a few minutes by direct irradiation with 405 nm light. To overcome this problem, we fabricated a simple device designed to detect the fluorescence intensity immediately after inserting a reaction strip into the device. The linearity of the calibration was obtained over a range of 1–100 µM of cyanide with good repeatability. The device is cost-effective (~ $300) and powered by batteries; therefore, it is suitable for the on-site determination of cyanide in crude samples.

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Acknowledgements

This study was supported by the MEXT-Supported Program for the Strategic Research Foundation at Private Universities (S1411037, 2014–2018). We thank Kindai University Joint Research Center for use of facilities.

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Authors and Affiliations

  1. Forensic Science Laboratory, Kyoto Prefectural Police H.Q., 85-3, Yabunouchi-cho, Kamigyo-ku, Kyoto, 602-8550, Japan

    Yasuhiro Morikawa

  2. Department of Pharmaceutical Sciences, Faculty of Pharmacy, Kindai University, 3-4-1, Kowakae, Higashi-osaka, Osaka, 577-8502, Japan

    Keiji Nishiwaki, Shigeo Suzuki, Mitsuhiro Kinoshita & Isao Nakanishi

  3. Antiaging Center, Kindai University, 3-4-1, Kowakae, Higashi-osaka, Osaka, 577-8502, Japan

    Shigeo Suzuki & Isao Nakanishi

Authors
  1. Yasuhiro Morikawa
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  2. Keiji Nishiwaki
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  3. Shigeo Suzuki
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  4. Mitsuhiro Kinoshita
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  5. Isao Nakanishi
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Correspondence to Yasuhiro Morikawa.

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Morikawa, Y., Nishiwaki, K., Suzuki, S. et al. Development of a cost-effective laser diode-induced fluorescence detection instrument for cyanide detection. ANAL. SCI. 38, 437–442 (2022). https://doi.org/10.1007/s44211-022-00065-y

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  • DOI: https://doi.org/10.1007/s44211-022-00065-y

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