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Genotoxicity Induced by Dental Implants In Vitro and In Vivo? A Systematic Review with Meta-analysis

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Abstract

The aim of this systematic review was designed to help further elucidate the following question: Are dental implants able to induce DNA damage in vitro or in vivo? The systematic review was conducted according to the PRISMA-P guidelines. After searching the literature, full manuscripts from 19 studies were carefully selected by the authors. Regarding the general characteristics, endosseous implant was studied in ten manuscripts, and titanium disks were researched by 4 authors; two studies evaluated more than one type of material: titanium miniplates and endosseous implants, cylinders; endosseous implants and rectangular-shaped titanium miniplates, ceramic composites and titanium particles were research objects only once. Following the parameters for evaluating the risk assessment, 7 manuscripts had strong scores, another 8 papers reached the moderate score, and another 4 scored poorly. The meta-analysis data did not reveal a statistically significant difference in the micronucleated cells of the dental implants patients compared to the control (SMD = 0.22, 95% CI − 0.12 to 0.56, p = 0.20), with a Tau2 = 0.00; Chi2 = 0.01, and p = 0.92, so that the selected manuscripts were considered homogeneous and the I2 of 0% indicated low heterogeneity. In our findings, after evaluating the works, it was observed that the results of the characteristics of the dental implants did not induce genotoxicity.

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Funding

The authors acknowledge research grants received from CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico) for productivity fellowships.

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Authors and Affiliations

  1. Department of Biosciences, Institute of Health and Society, Federal University of São Paulo, UNIFESP, Rua Silva Jardim, 136, Room 332, Vila Mathias, Santos, SP, 11050-020, Brazil

    Ingra Tais Malacarne, Ana Claudia Muniz Renno & Daniel Araki Ribeiro

  2. Department of Diagnosis and Surgery, School of Dentistry, Sao Paulo State University, UNESP, Araçatuba, SP, Brazil

    Wilton Mitsunari Takeshita

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  1. Ingra Tais Malacarne
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Correspondence to Daniel Araki Ribeiro.

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Malacarne, I.T., Takeshita, W.M., Renno, A.C.M. et al. Genotoxicity Induced by Dental Implants In Vitro and In Vivo? A Systematic Review with Meta-analysis. Biomedical Materials & Devices (2023). https://doi.org/10.1007/s44174-023-00128-2

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