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The potential effect of Polypodium leucotomos extract on ultraviolet- and visible light-induced photoaging

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Abstract

Photoaging induced by both ultraviolet and visible light has been shown to lead to increased inflammation and dysregulation of the extracellular matrix. Standardized extract of the Polypodium leucotomos fern, PLE, possesses anti-inflammatory and antioxidant properties, and has been shown to potentially mitigate photoaging through various mechanisms. This comprehensive review presents the data available on the effects of P. leucotomos extract on UV and VL-induced photoaging in vitro as well as in vivo in murine and human models.

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Abbreviations

ABTS:

2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salts

AP1:

Activator protein 1

COX2:

Cyclooxygenase 2

CPD:

Cyclobutane pyrimidine dimer

FRAP:

Ferric reducing antioxidant power

H2AX:

H2A histone family member X

H2O2 :

Hydrogen peroxide

HPLC:

High performance liquid chromatography

HSP:

Heat shock protein

i-NOS:

Inducible nitric oxide synthase

IL:

Interleukin

LDH:

Lactate dehydrogenase

MART-1:

Melanoma antigen recognized by T cells 1

MED:

Minimal erythema dose

MMP:

Matrix metalloproteinase

NF-kB:

Nuclear factor KB

NRF2:

Nuclear factor erythroid 2-related factor 2

NO:

Nitric oxide

TGF-β:

Tumor growth factor-β

TIMP:

Tissue inhibitor of matrix metalloproteinase

TiO2 :

Titanium dioxide

TNF-α:

Tumor necrosis factor

UCA:

Urocanic acid

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Authors and Affiliations

  1. Photomedicine and Photobiology Unit, Department of Dermatology, Henry Ford Health System, 3031 W. Grand Blvd, Suite 800, Detroit, MI, 48202, USA

    Aunna Pourang, Nneamaka Ezekwe, Indermeet Kohli, Iltefat Hamzavi & Henry W. Lim

  2. College of Medicine, Michigan State University, East Lansing, MI, USA

    Mohsen Dourra

Authors
  1. Aunna Pourang
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  2. Mohsen Dourra
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  3. Nneamaka Ezekwe
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  4. Indermeet Kohli
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  5. Iltefat Hamzavi
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Contributions

All authors whose names appear on the submission: 1. Made substantial contributions to the conception or design of the work; or the acquisition, analysis, or interpretation of data; or the creation of new software used in the work; 2. Drafted the work or revised it critically for important intellectual content; 3. Approved the version to be published; and; 4. Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

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Correspondence to Henry W. Lim.

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Conflict of interest

Henry W. Lim has served as investigator/co-investigator for research studies sponsored by Incyte, L’Oréal, Pfizer, and PCORI; he has served as a consultant for Pierre Fabre, ISDIN, Ferndale, Galderma, La Roche-Posay, and Beiersdorf; he has been a speaker on general education sessions for La Roche-Posay, and Cantabria Labs. Iltefat Hamzavi has served as an advisory board member for AbbVie; a consultant for Incyte, Pfizer, and UCB; a principal investigator for AbbVie, Allergan, Bayer, Clinuvel Pharmaceuticals, Este Lauder, Ferndale Laboratories, Galderma Laboratories LP, GE Healthcare, Incyte, Janssen, Janssen Biotech, Johnson & Johnson, Lenicura, LEO Pharma, Pfizer, and Unigen; a subinvestigator for Amgen, Bristol-Myers Squibb, Foamix Pharmaceuticals, and Janssen; president of the HS Foundation; and co-chair of the Global Vitiligo Foundation. Indermeet Kohli is an Investigator for Ferndale, Estee Lauder, L’Oreal, Unigen, Johnson and Johnson, Allergan and Bayer with grant received by the institution and is a Consultant for Pfizer, Johnson and Johnson, and Bayer with fee and equipment received by the institution. Aunna Pourang is a subinvestigator for Pfizer, Biofrontera and L’Oreal. Nneamaka Ezekwe is a subinvestigator for Pfizer, Biofrontera and L’Oreal. Mohsen Dourra has no conflicts of interest or disclosures.

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Pourang, A., Dourra, M., Ezekwe, N. et al. The potential effect of Polypodium leucotomos extract on ultraviolet- and visible light-induced photoaging. Photochem Photobiol Sci 20, 1229–1238 (2021). https://doi.org/10.1007/s43630-021-00087-x

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