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Does Platelet-Rich Plasma Deserve a Role in Accelerating the Recovery of Reflex Sympathetic Dystrophy Following Distal Radius Fracture?

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Abstract

Introduction

This study was to evaluate the efficacy of multiple platelet-rich plasma injections in reflex sympathetic dystrophy following distal radius fracture after previous various treatments have failed.

Materials and methods

This comparative prospective study was designed for 64 patients of reflex sympathetic dystrophy developed following distal radius fracture, from January 2009 to December 2020 were enrolled in this study. This cohort of patient was given either four multiple subcutaneous platelet-rich plasma injections at weekly interval (n = 32) or two injections in a month with 15 days interval (n = 32). The primary outcome measure assessed with patient rated wrist evaluation questionnaire score. The secondary outcome was a visual analogue scale pain score. The final follow up was at 2 years. p ≤ 0.05 is considered statistically.

Results

The patient rated wrist evaluation score for usual and specific activities and EQ-VAS for pain level showed statistically significant greater improvement in group A (42 \(\pm\)21%) compared to group B (19 \(\pm\) 24%), (p = 0.37). Patients also had improvement in wrist movements with no statistically significant differences in both groups. The standard difference in means of all three functional scores was almost similar between both groups A and B (standard difference in means = 0.032; 95% CI 0.236–0.830; p = 0.495), considered clinically meaningful.

Conclusion

This study results suggest autologous platelet-rich plasma injections seem to be safe, cost effective, efficacious algorithm treatment for reflex sympathetic dystrophy following distal radius fracture patients where previous treatments have failed.

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Funding

The authors did not receive support from any organization for the submitted work. No funding was received to assist with the preparation of this manuscript. No funding was received for conducting this study. No funds, grants, or other support was received.

Author information

Author notes

  1. Raghavendra S. Kulkarni

    Present address: SSPM Medical College and Lifetime Hospital Campus, Padve Sindhudurg, 415634, Maharashtra, India

  2. SriRam R. Kulkarni

    Present address: Department of Orthopaedics, ACPM Medical College and Hospital, Dhule Sindhudurg, India

  3. Rachana A. Kulkarni

    Present address: Department of Anatomy, Jawaharlal Nehru Medical College, Belgavi, India

  4. Ranjani R. Kulkarni

    Present address: Department of Physiology, CDSIMER Medical College, Dayanand Sagar University, Bangalore, India

Authors and Affiliations

  1. Government Hospital Devgad, Kudal Sindhudurg, India

    Raghavendra S. Kulkarni

  2. District Hospital, Oros Sindhudurg, India

    Raghavendra S. Kulkarni

  3. Government Medical College and District Hospital, Oros Sindhudurg, India

    SriRam R. Kulkarni

  4. District Hospital, Oros Sindhudurg, 416812, India

    Rachana A. Kulkarni

  5. ECHS, Government Polyclinic, Oros Sindhudurg, 416812, India

    Ranjani R. Kulkarni

Authors
  1. Raghavendra S. Kulkarni
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  4. Ranjani R. Kulkarni
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Contributions

Conceptualization: Raghavendra Shankar Kulkarni and Rachana Raghavendra Kulkarni; methodology: SriRam Raghavendra Kulkarni; frmal analysis and investigation: Rachana Raghavendra Kulkarni; writing—original draft preparation: Ranjani Raghavendra Kulkarni and Raghavendra Shankar Kulkarni and SriRam Raghavendra Kulkarni; writing—review and editing: Raghavendra Shankar Kulkarni and SriRam Raghavendra Kulkarni; supervision: Rachana Raghavendra Kulkarni and Ranjani Raghavendra Kulkarni.

Corresponding author

Correspondence to Raghavendra S. Kulkarni.

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Conflict of interests

The authors have no relevant financial or non-financial interests to disclose. The authors have no competing interests to declare that are relevant to the content of this article. All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript. The authors have no financial or proprietary interests in any material discussed in this article.

Ethics approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The treatment protocols were approved by the local hospital Ethical Committee.

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Informed consent was obtained from all individual participants included in the study. Written informed consent was obtained from each patient.

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Kulkarni, R.S., Kulkarni, S.R., Kulkarni, R.A. et al. Does Platelet-Rich Plasma Deserve a Role in Accelerating the Recovery of Reflex Sympathetic Dystrophy Following Distal Radius Fracture?. JOIO (2024). https://doi.org/10.1007/s43465-024-01171-x

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