Skip to main content

Advertisement

Log in

Outcomes of Dorsolumbar and Lumbar Spinal Tuberculosis Treated by Minimally Invasive and Open Techniques: A Prospective Comparative Study

  • Original Article
  • Published:
Indian Journal of Orthopaedics Aims and scope Submit manuscript

Abstract

Purpose of Study

To compare the outcomes of minimally invasive and open techniques in the surgical management of dorsolumbar and lumbar spinal tuberculosis (STB).

Methods

Skeletally mature patients with active STB involving thoracolumbar and lumbar region confirmed by radiology (X-ray, MRI) and histopathological examination were included. Healed and mechanically stable STB, patients having severe hepatic and renal impairment, coexisting spinal conditions such as ankylosing spondylitis and rheumatoid arthritis, and patients unwilling to participate were excluded from the study. The patients were divided in to two groups, group A consisted of patients treated by MIS techniques and group B consisted of patients treated by open techniques. All the patients had a minimum follow-up of 24 months.

Results

A total of 42 patients were included in the study. MIS techniques were used in 18 patients and open techniques were used in 24 patients. On comparison between the two groups, blood loss (234 ml vs 742 ml), and immediate post-operative VAS score (5.26 vs 7.08) were significantly better in group A, whereas kyphotic correction (16° vs 33.25°) was significantly better in group B. Rest of the parameters such as duration of surgery, VAS score, ODI score and number of instrumented levels did not show significant difference between the two groups.

Conclusion

MIS stabilization when compared to open techniques is associated with significant improvement in immediate post-operative VAS scores. The MIS approaches at 2-year follow-up have functional results similar to open techniques. MIS is inferior to open techniques in kyphosis correction and may be associated with complications.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Rieger, B., Jiang, H., Ruess, D., Reinshagen, C., Molcanyi, M., Zivcak, J., et al. (2017). First clinical results of minimally invasive vector lumbar interbody fusion (MIS-VLIF) in spondylodiscitis and concomitant osteoporosis: A technical note. European Spine Journal: Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 26(12), 3147–3155. https://doi.org/10.1007/s00586-016-4928-z

    Article  PubMed  Google Scholar 

  2. Khan, N. R., Clark, A. J., Lee, S. L., Venable, G. T., Rossi, N. B., & Foley, K. T. (2015). Surgical outcomes for minimally invasive vs open transforaminal lumbar interbody fusion: An updated systematic review and meta-analysis. Neurosurgery, 77(6), 847–874. https://doi.org/10.1227/NEU.0000000000000913. discussion 874.

    Article  PubMed  Google Scholar 

  3. Turel, M. K., Kerolus, M., & Deutsch, H. (2017). The role of minimally invasive spine surgery in the management of pyogenic spinal discitis. Journal of Craniovertebral Junction & Spine, 8(1), 39–43. https://doi.org/10.4103/0974-8237.199873

    Article  Google Scholar 

  4. Tschugg, A., Hartmann, S., Lener, S., Rietzler, A., Sabrina, N., & Thomé, C. (2017). Minimally invasive spine surgery in lumbar spondylodiscitis: A retrospective single-center analysis of 67 cases. European Spine Journal, 26(12), 3141–3146. https://doi.org/10.1007/s00586-017-5180-x

    Article  PubMed  Google Scholar 

  5. Lin, T.-Y., Tsai, T.-T., Lu, M.-L., Niu, C.-C., Hsieh, M.-K., Fu, T.-S., et al. (2014). Comparison of two-stage open versus percutaneous pedicle screw fixation in treating pyogenic spondylodiscitis. BMC Musculoskeletal Disorders, 15, 443. https://doi.org/10.1186/1471-2474-15-443

    Article  PubMed  PubMed Central  Google Scholar 

  6. Jayaswal, A., Upendra, B., Ahmed, A., Chowdhury, B., & Kumar, A. (2007). Video-assisted thoracoscopic anterior surgery for tuberculous spondylitis. Clinical Orthopaedics and Related Research, 460, 100–107. https://doi.org/10.1097/BLO.0b013e318065b6e4

    Article  PubMed  Google Scholar 

  7. McLain, R. F. (2001). Spinal cord decompression: An endoscopically assisted approach for metastatic tumors. Spinal Cord, 39(9), 482–487. https://doi.org/10.1038/sj.sc.3101194

    Article  CAS  PubMed  Google Scholar 

  8. Kandwal, P., Upendra, B., Jayaswal, A., Garg, B., & Chowdhury, B. (2012). Outcome of minimally invasive surgery in the management of tuberculous spondylitis. Indian Journal of Orthopaedics, 46(2), 159. https://doi.org/10.4103/0019-5413.93680

    Article  PubMed  PubMed Central  Google Scholar 

  9. Kandwal, P., & VijayaraghavanJayaswal, G. A. (2016). Management of tuberculous infection of the spine. Asian Spine Journal, 10(4), 792–800. https://doi.org/10.4184/asj.2016.10.4.792

    Article  PubMed  PubMed Central  Google Scholar 

  10. Ahuja, K., Gupta, T., Ifthekar, S., Mittal, S., Yadav, G., & Kandwal, P. (2022). Variability in management practices and surgical decision making in spinal tuberculosis: an expert survey-based study. Asian Spine Journal, 16(1), 9–19. https://doi.org/10.31616/asj.2020.0557

    Article  PubMed  Google Scholar 

  11. Rigotti, S., Boriani, L., Luzi, C. A., Marocco, S., Angheben, A., Gasbarrini, A., et al. (2013). Minimally invasive posterior stabilization for treating spinal tuberculosis. Journal of Orthopaedics and Traumatology, 14(2), 143–145. https://doi.org/10.1007/s10195-012-0184-0

    Article  CAS  PubMed  Google Scholar 

  12. Yadav, G., Kandwal, P., & Arora, S. S. (2020). Short-term outcome of lamina-sparing decompression in thoracolumbar spinal tuberculosis. Journal of Neurosurgery Spine. https://doi.org/10.3171/2020.1.SPINE191152

    Article  PubMed  Google Scholar 

  13. Bridwell, K. H., Lenke, L. G., McEnery, K. W., Baldus, C., & Blanke, K. (1995). Anterior fresh frozen structural allografts in the thoracic and lumbar spine. Do they work if combined with posterior fusion and instrumentation in adult patients with kyphosis or anterior column defects? Spine, 20(12), 1410–1418.

    Article  CAS  PubMed  Google Scholar 

  14. Ahuja, K., Kandwal, P., Ifthekar, S., Sudhakar, P. V., Nene, A., Basu, S., et al. (2022). Development of tuberculosis spine instability score (TSIS): An evidence-based and expert consensus-based content validation study among spine surgeons. Spine, 47(3), 242–251. https://doi.org/10.1097/BRS.0000000000004173

    Article  PubMed  Google Scholar 

  15. Ahuja, K., Ifthekar, S., Mittal, S., Yadav, G., Sarkar, B., & Kandwal, P. (2021). Defining mechanical instability in tuberculosis of the spine: A systematic review. EFORT Open Reviews, 6(3), 202–210. https://doi.org/10.1302/2058-5241.6.200113

    Article  PubMed  PubMed Central  Google Scholar 

  16. Stevens, K. J., Spenciner, D. B., Griffiths, K. L., Kim, K. D., Zwienenberg-Lee, M., Alamin, T., et al. (2006). Comparison of minimally invasive and conventional open posterolateral lumbar fusion using magnetic resonance imaging and retraction pressure studies. Journal of Spinal Disorders & Techniques, 19(2), 77–86. https://doi.org/10.1097/01.bsd.0000193820.42522.d9

    Article  Google Scholar 

  17. Fan, W., Yang, G., Zhou, T., Chen, Y., Gao, Z., Zhou, W., et al. (2022). One-stage freehand minimally invasive pedicle screw fixation combined with mini-access surgery through OLIF approach for the treatment of lumbar tuberculosis. Journal of Orthopaedic Surgery and Research, 17(1), 242. https://doi.org/10.1186/s13018-022-03130-4

    Article  PubMed  PubMed Central  Google Scholar 

  18. Leong, G., Wilson, J., & Charlett, A. (2006). Duration of operation as a risk factor for surgical site infection: Comparison of English and US data. The Journal of Hospital Infection, 63(3), 255–262. https://doi.org/10.1016/j.jhin.2006.02.007

    Article  CAS  PubMed  Google Scholar 

  19. Chen, M.J.-W., Niu, C.-C., Hsieh, M.-K., Luo, A.-J., Fu, T.-S., Lai, P.-L., et al. (2019). Minimally invasive transforaminal lumbar interbody debridement and fusion with percutaneous pedicle screw instrumentation for spondylodiscitis. World Neurosurgery, 128, e744–e751. https://doi.org/10.1016/j.wneu.2019.04.249

    Article  PubMed  Google Scholar 

  20. Ifthekar, S., Yadav, G., Ahuja, K., Mittal, S., Venkata, S. P., & Kandwal, P. (2022). Correlation of spinopelvic parameters with functional outcomes in surgically managed cases of lumbar spinal tuberculosis—A retrospective study. Journal of Clinical Orthopaedics and Trauma, 26, 101788. https://doi.org/10.1016/j.jcot.2022.101788

    Article  PubMed  PubMed Central  Google Scholar 

  21. Goyal, N., Ahuja, K., Yadav, G., Gupta, T., Ifthekar, S., & Kandwal, P. (2021). PEEK vs titanium cage for anterior column reconstruction in active spinal tuberculosis: A comparative study. Neurology India, 69(4), 966. https://doi.org/10.4103/0028-3886.325384

    Article  PubMed  Google Scholar 

  22. Klöckner, C., & Valencia, R. (2003). Sagittal alignment after anterior debridement and fusion with or without additional posterior instrumentation in the treatment of pyogenic and tuberculous spondylodiscitis. Spine, 28(10), 1036–1042. https://doi.org/10.1097/01.BRS.0000061991.11489.7F

    Article  PubMed  Google Scholar 

  23. Chen, W.-J., Wu, C.-C., Jung, C.-H., Chen, L.-H., Niu, C.-C., & Lai, P.-L. (2002). Combined anterior and posterior surgeries in the treatment of spinal tuberculous spondylitis. Clinical Orthopaedics and Related Research, 398, 50–59.

    Article  Google Scholar 

  24. Lee, S.-H., Sung, J.-K., & Park, Y.-M. (2006). Single-stage transpedicular decompression and posterior instrumentation in treatment of thoracic and thoracolumbar spinal tuberculosis: A retrospective case series. Journal of Spinal Disorders & Techniques, 19(8), 595–602. https://doi.org/10.1097/01.bsd.0000211241.06588.7b

    Article  Google Scholar 

  25. Pu, X., Zhou, Q., He, Q., Dai, F., Xu, J., Zhang, Z., et al. (2012). A posterior versus anterior surgical approach in combination with debridement, interbody autografting and instrumentation for thoracic and lumbar tuberculosis. International Orthopaedics, 36(2), 307–313. https://doi.org/10.1007/s00264-011-1329-0

    Article  PubMed  Google Scholar 

  26. Upadhyay, S. S., Saji, M. J., Sell, P., Sell, B., & Yau, A. C. (1994). Longitudinal changes in spinal deformity after anterior spinal surgery for tuberculosis of the spine in adults. A comparative analysis between radical and debridement surgery. Spine, 19(5), 542–549. https://doi.org/10.1097/00007632-199403000-00009

    Article  CAS  PubMed  Google Scholar 

  27. Jain, A. K., Dhammi, I. K., Jain, S., & Mishra, P. (2010). Kyphosis in spinal tuberculosis—Prevention and correction. Indian Journal of Orthopaedics, 44(2), 127–136. https://doi.org/10.4103/0019-5413.61893

    Article  PubMed  PubMed Central  Google Scholar 

  28. Jain, A., Jain, R. K., & Kiyawat, V. (2017). Evaluation of outcome of transpedicular decompression and instrumented fusion in thoracic and thoracolumbar tuberculosis. Asian Spine Journal, 11(1), 31–36. https://doi.org/10.4184/asj.2017.11.1.31

    Article  PubMed  PubMed Central  Google Scholar 

  29. Wu, P., Luo, C., Pang, X., Xu, Z., Zeng, H., & Wang, X. (2013). Surgical treatment of thoracic spinal tuberculosis with adjacent segments lesion via one-stage transpedicular debridement, posterior instrumentation and combined interbody and posterior fusion, a clinical study. Archives of Orthopaedic and Trauma Surgery, 133(10), 1341–1350. https://doi.org/10.1007/s00402-013-1811-9

    Article  PubMed  Google Scholar 

  30. El-Sharkawi, M. M., & Said, G. Z. (2012). Instrumented circumferential fusion for tuberculosis of the dorso-lumbar spine. A single or double stage procedure? International Orthopaedics, 36(2), 315–324. https://doi.org/10.1007/s00264-011-1401-9

    Article  PubMed  Google Scholar 

  31. Yeraagunta, T., Yerramneni, V. K., Kanala, R. R., Gaikwad, G., Kumar, H. D. P., & Phutane, A. S. (2020). Minimally invasive spinal fusion and decompression for thoracolumbar spondylodiscitis. Journal of Craniovertebral Junction and Spine, 11(1), 17. https://doi.org/10.4103/jcvjs.JCVJS_24_20

    Article  PubMed  PubMed Central  Google Scholar 

  32. Zhang, H., Huang, S., Guo, H., Ge, L., Sheng, B., Wang, Y., et al. (2012). A clinical study of internal fixation, debridement and interbody thoracic fusion to treat thoracic tuberculosis via posterior approach only. International Orthopaedics, 36(2), 293–298. https://doi.org/10.1007/s00264-011-1449-6

    Article  CAS  PubMed  Google Scholar 

  33. Zaveri, G. R., & Mehta, S. S. (2009). Surgical treatment of lumbar tuberculous spondylodiscitis by transforaminal lumbar interbody fusion (TLIF) and posterior instrumentation. Journal of Spinal Disorders & Techniques, 22(4), 257–262. https://doi.org/10.1097/BSD.0b013e31818859d0

    Article  Google Scholar 

  34. Bhojraj, S., & Nene, A. (2002). Lumbar and lumbosacral tuberculous spondylodiscitis in adults. Redefining the indications for surgery. The Journal of Bone and Joint Surgery British, 84(4), 530–534. https://doi.org/10.1302/0301-620x.84b4.12363

    Article  CAS  Google Scholar 

  35. Garg, N., & Vohra, R. (2014). Minimally invasive surgical approaches in the management of tuberculosis of the thoracic and lumbar spine. Clinical Orthopaedics and Related Research, 472(6), 1855–1867. https://doi.org/10.1007/s11999-014-3472-6

    Article  PubMed  PubMed Central  Google Scholar 

  36. Ito, M., Sudo, H., Abumi, K., Kotani, Y., Takahata, M., Fujita, M., et al. (2009). Minimally invasive surgical treatment for tuberculous spondylodiscitis. Minimally Invasive Neurosurgery, 52(05/06), 250–253. https://doi.org/10.1055/s-0029-1220685

    Article  CAS  PubMed  Google Scholar 

  37. Lü, G., Wang, B., Li, J., Liu, W., & Cheng, I. (2012). Anterior debridement and reconstruction via thoracoscopy-assisted mini-open approach for the treatment of thoracic spinal tuberculosis: Minimum 5-year follow-up. European Spine Journal: Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 21(3), 463–469. https://doi.org/10.1007/s00586-011-2038-5

    Article  PubMed  Google Scholar 

  38. De Iure, F., Cappuccio, M., Paderni, S., Bosco, G., & Amendola, L. (2012). Minimal invasive percutaneous fixation of thoracic and lumbar spine fractures. Minimally Invasive Surgery, 2012, e141032. https://doi.org/10.1155/2012/141032

    Article  Google Scholar 

  39. Court, C., & Vincent, C. (2012). Percutaneous fixation of thoracolumbar fractures: Current concepts. Orthopaedics & Traumatology, Surgery & Research: OTSR, 98(8), 900–909. https://doi.org/10.1016/j.otsr.2012.09.014

    Article  CAS  Google Scholar 

Download references

Funding

No funds, grants, or other support was received.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Pankaj Kandwal.

Ethics declarations

Conflict of Interest

None.

Ethical Standard Statement

This article does not contain any studies with human or animal subjects performed by the any of the authors.

Informed Consent

For this type of study, informed consent is not required.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ifthekar, S., Ahuja, K., Mittal, S. et al. Outcomes of Dorsolumbar and Lumbar Spinal Tuberculosis Treated by Minimally Invasive and Open Techniques: A Prospective Comparative Study. JOIO (2024). https://doi.org/10.1007/s43465-024-01123-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s43465-024-01123-5

Keywords

Navigation