Abstract
Purpose of Study
To compare the outcomes of minimally invasive and open techniques in the surgical management of dorsolumbar and lumbar spinal tuberculosis (STB).
Methods
Skeletally mature patients with active STB involving thoracolumbar and lumbar region confirmed by radiology (X-ray, MRI) and histopathological examination were included. Healed and mechanically stable STB, patients having severe hepatic and renal impairment, coexisting spinal conditions such as ankylosing spondylitis and rheumatoid arthritis, and patients unwilling to participate were excluded from the study. The patients were divided in to two groups, group A consisted of patients treated by MIS techniques and group B consisted of patients treated by open techniques. All the patients had a minimum follow-up of 24 months.
Results
A total of 42 patients were included in the study. MIS techniques were used in 18 patients and open techniques were used in 24 patients. On comparison between the two groups, blood loss (234 ml vs 742 ml), and immediate post-operative VAS score (5.26 vs 7.08) were significantly better in group A, whereas kyphotic correction (16° vs 33.25°) was significantly better in group B. Rest of the parameters such as duration of surgery, VAS score, ODI score and number of instrumented levels did not show significant difference between the two groups.
Conclusion
MIS stabilization when compared to open techniques is associated with significant improvement in immediate post-operative VAS scores. The MIS approaches at 2-year follow-up have functional results similar to open techniques. MIS is inferior to open techniques in kyphosis correction and may be associated with complications.
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References
Rieger, B., Jiang, H., Ruess, D., Reinshagen, C., Molcanyi, M., Zivcak, J., et al. (2017). First clinical results of minimally invasive vector lumbar interbody fusion (MIS-VLIF) in spondylodiscitis and concomitant osteoporosis: A technical note. European Spine Journal: Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 26(12), 3147–3155. https://doi.org/10.1007/s00586-016-4928-z
Khan, N. R., Clark, A. J., Lee, S. L., Venable, G. T., Rossi, N. B., & Foley, K. T. (2015). Surgical outcomes for minimally invasive vs open transforaminal lumbar interbody fusion: An updated systematic review and meta-analysis. Neurosurgery, 77(6), 847–874. https://doi.org/10.1227/NEU.0000000000000913. discussion 874.
Turel, M. K., Kerolus, M., & Deutsch, H. (2017). The role of minimally invasive spine surgery in the management of pyogenic spinal discitis. Journal of Craniovertebral Junction & Spine, 8(1), 39–43. https://doi.org/10.4103/0974-8237.199873
Tschugg, A., Hartmann, S., Lener, S., Rietzler, A., Sabrina, N., & Thomé, C. (2017). Minimally invasive spine surgery in lumbar spondylodiscitis: A retrospective single-center analysis of 67 cases. European Spine Journal, 26(12), 3141–3146. https://doi.org/10.1007/s00586-017-5180-x
Lin, T.-Y., Tsai, T.-T., Lu, M.-L., Niu, C.-C., Hsieh, M.-K., Fu, T.-S., et al. (2014). Comparison of two-stage open versus percutaneous pedicle screw fixation in treating pyogenic spondylodiscitis. BMC Musculoskeletal Disorders, 15, 443. https://doi.org/10.1186/1471-2474-15-443
Jayaswal, A., Upendra, B., Ahmed, A., Chowdhury, B., & Kumar, A. (2007). Video-assisted thoracoscopic anterior surgery for tuberculous spondylitis. Clinical Orthopaedics and Related Research, 460, 100–107. https://doi.org/10.1097/BLO.0b013e318065b6e4
McLain, R. F. (2001). Spinal cord decompression: An endoscopically assisted approach for metastatic tumors. Spinal Cord, 39(9), 482–487. https://doi.org/10.1038/sj.sc.3101194
Kandwal, P., Upendra, B., Jayaswal, A., Garg, B., & Chowdhury, B. (2012). Outcome of minimally invasive surgery in the management of tuberculous spondylitis. Indian Journal of Orthopaedics, 46(2), 159. https://doi.org/10.4103/0019-5413.93680
Kandwal, P., & VijayaraghavanJayaswal, G. A. (2016). Management of tuberculous infection of the spine. Asian Spine Journal, 10(4), 792–800. https://doi.org/10.4184/asj.2016.10.4.792
Ahuja, K., Gupta, T., Ifthekar, S., Mittal, S., Yadav, G., & Kandwal, P. (2022). Variability in management practices and surgical decision making in spinal tuberculosis: an expert survey-based study. Asian Spine Journal, 16(1), 9–19. https://doi.org/10.31616/asj.2020.0557
Rigotti, S., Boriani, L., Luzi, C. A., Marocco, S., Angheben, A., Gasbarrini, A., et al. (2013). Minimally invasive posterior stabilization for treating spinal tuberculosis. Journal of Orthopaedics and Traumatology, 14(2), 143–145. https://doi.org/10.1007/s10195-012-0184-0
Yadav, G., Kandwal, P., & Arora, S. S. (2020). Short-term outcome of lamina-sparing decompression in thoracolumbar spinal tuberculosis. Journal of Neurosurgery Spine. https://doi.org/10.3171/2020.1.SPINE191152
Bridwell, K. H., Lenke, L. G., McEnery, K. W., Baldus, C., & Blanke, K. (1995). Anterior fresh frozen structural allografts in the thoracic and lumbar spine. Do they work if combined with posterior fusion and instrumentation in adult patients with kyphosis or anterior column defects? Spine, 20(12), 1410–1418.
Ahuja, K., Kandwal, P., Ifthekar, S., Sudhakar, P. V., Nene, A., Basu, S., et al. (2022). Development of tuberculosis spine instability score (TSIS): An evidence-based and expert consensus-based content validation study among spine surgeons. Spine, 47(3), 242–251. https://doi.org/10.1097/BRS.0000000000004173
Ahuja, K., Ifthekar, S., Mittal, S., Yadav, G., Sarkar, B., & Kandwal, P. (2021). Defining mechanical instability in tuberculosis of the spine: A systematic review. EFORT Open Reviews, 6(3), 202–210. https://doi.org/10.1302/2058-5241.6.200113
Stevens, K. J., Spenciner, D. B., Griffiths, K. L., Kim, K. D., Zwienenberg-Lee, M., Alamin, T., et al. (2006). Comparison of minimally invasive and conventional open posterolateral lumbar fusion using magnetic resonance imaging and retraction pressure studies. Journal of Spinal Disorders & Techniques, 19(2), 77–86. https://doi.org/10.1097/01.bsd.0000193820.42522.d9
Fan, W., Yang, G., Zhou, T., Chen, Y., Gao, Z., Zhou, W., et al. (2022). One-stage freehand minimally invasive pedicle screw fixation combined with mini-access surgery through OLIF approach for the treatment of lumbar tuberculosis. Journal of Orthopaedic Surgery and Research, 17(1), 242. https://doi.org/10.1186/s13018-022-03130-4
Leong, G., Wilson, J., & Charlett, A. (2006). Duration of operation as a risk factor for surgical site infection: Comparison of English and US data. The Journal of Hospital Infection, 63(3), 255–262. https://doi.org/10.1016/j.jhin.2006.02.007
Chen, M.J.-W., Niu, C.-C., Hsieh, M.-K., Luo, A.-J., Fu, T.-S., Lai, P.-L., et al. (2019). Minimally invasive transforaminal lumbar interbody debridement and fusion with percutaneous pedicle screw instrumentation for spondylodiscitis. World Neurosurgery, 128, e744–e751. https://doi.org/10.1016/j.wneu.2019.04.249
Ifthekar, S., Yadav, G., Ahuja, K., Mittal, S., Venkata, S. P., & Kandwal, P. (2022). Correlation of spinopelvic parameters with functional outcomes in surgically managed cases of lumbar spinal tuberculosis—A retrospective study. Journal of Clinical Orthopaedics and Trauma, 26, 101788. https://doi.org/10.1016/j.jcot.2022.101788
Goyal, N., Ahuja, K., Yadav, G., Gupta, T., Ifthekar, S., & Kandwal, P. (2021). PEEK vs titanium cage for anterior column reconstruction in active spinal tuberculosis: A comparative study. Neurology India, 69(4), 966. https://doi.org/10.4103/0028-3886.325384
Klöckner, C., & Valencia, R. (2003). Sagittal alignment after anterior debridement and fusion with or without additional posterior instrumentation in the treatment of pyogenic and tuberculous spondylodiscitis. Spine, 28(10), 1036–1042. https://doi.org/10.1097/01.BRS.0000061991.11489.7F
Chen, W.-J., Wu, C.-C., Jung, C.-H., Chen, L.-H., Niu, C.-C., & Lai, P.-L. (2002). Combined anterior and posterior surgeries in the treatment of spinal tuberculous spondylitis. Clinical Orthopaedics and Related Research, 398, 50–59.
Lee, S.-H., Sung, J.-K., & Park, Y.-M. (2006). Single-stage transpedicular decompression and posterior instrumentation in treatment of thoracic and thoracolumbar spinal tuberculosis: A retrospective case series. Journal of Spinal Disorders & Techniques, 19(8), 595–602. https://doi.org/10.1097/01.bsd.0000211241.06588.7b
Pu, X., Zhou, Q., He, Q., Dai, F., Xu, J., Zhang, Z., et al. (2012). A posterior versus anterior surgical approach in combination with debridement, interbody autografting and instrumentation for thoracic and lumbar tuberculosis. International Orthopaedics, 36(2), 307–313. https://doi.org/10.1007/s00264-011-1329-0
Upadhyay, S. S., Saji, M. J., Sell, P., Sell, B., & Yau, A. C. (1994). Longitudinal changes in spinal deformity after anterior spinal surgery for tuberculosis of the spine in adults. A comparative analysis between radical and debridement surgery. Spine, 19(5), 542–549. https://doi.org/10.1097/00007632-199403000-00009
Jain, A. K., Dhammi, I. K., Jain, S., & Mishra, P. (2010). Kyphosis in spinal tuberculosis—Prevention and correction. Indian Journal of Orthopaedics, 44(2), 127–136. https://doi.org/10.4103/0019-5413.61893
Jain, A., Jain, R. K., & Kiyawat, V. (2017). Evaluation of outcome of transpedicular decompression and instrumented fusion in thoracic and thoracolumbar tuberculosis. Asian Spine Journal, 11(1), 31–36. https://doi.org/10.4184/asj.2017.11.1.31
Wu, P., Luo, C., Pang, X., Xu, Z., Zeng, H., & Wang, X. (2013). Surgical treatment of thoracic spinal tuberculosis with adjacent segments lesion via one-stage transpedicular debridement, posterior instrumentation and combined interbody and posterior fusion, a clinical study. Archives of Orthopaedic and Trauma Surgery, 133(10), 1341–1350. https://doi.org/10.1007/s00402-013-1811-9
El-Sharkawi, M. M., & Said, G. Z. (2012). Instrumented circumferential fusion for tuberculosis of the dorso-lumbar spine. A single or double stage procedure? International Orthopaedics, 36(2), 315–324. https://doi.org/10.1007/s00264-011-1401-9
Yeraagunta, T., Yerramneni, V. K., Kanala, R. R., Gaikwad, G., Kumar, H. D. P., & Phutane, A. S. (2020). Minimally invasive spinal fusion and decompression for thoracolumbar spondylodiscitis. Journal of Craniovertebral Junction and Spine, 11(1), 17. https://doi.org/10.4103/jcvjs.JCVJS_24_20
Zhang, H., Huang, S., Guo, H., Ge, L., Sheng, B., Wang, Y., et al. (2012). A clinical study of internal fixation, debridement and interbody thoracic fusion to treat thoracic tuberculosis via posterior approach only. International Orthopaedics, 36(2), 293–298. https://doi.org/10.1007/s00264-011-1449-6
Zaveri, G. R., & Mehta, S. S. (2009). Surgical treatment of lumbar tuberculous spondylodiscitis by transforaminal lumbar interbody fusion (TLIF) and posterior instrumentation. Journal of Spinal Disorders & Techniques, 22(4), 257–262. https://doi.org/10.1097/BSD.0b013e31818859d0
Bhojraj, S., & Nene, A. (2002). Lumbar and lumbosacral tuberculous spondylodiscitis in adults. Redefining the indications for surgery. The Journal of Bone and Joint Surgery British, 84(4), 530–534. https://doi.org/10.1302/0301-620x.84b4.12363
Garg, N., & Vohra, R. (2014). Minimally invasive surgical approaches in the management of tuberculosis of the thoracic and lumbar spine. Clinical Orthopaedics and Related Research, 472(6), 1855–1867. https://doi.org/10.1007/s11999-014-3472-6
Ito, M., Sudo, H., Abumi, K., Kotani, Y., Takahata, M., Fujita, M., et al. (2009). Minimally invasive surgical treatment for tuberculous spondylodiscitis. Minimally Invasive Neurosurgery, 52(05/06), 250–253. https://doi.org/10.1055/s-0029-1220685
Lü, G., Wang, B., Li, J., Liu, W., & Cheng, I. (2012). Anterior debridement and reconstruction via thoracoscopy-assisted mini-open approach for the treatment of thoracic spinal tuberculosis: Minimum 5-year follow-up. European Spine Journal: Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 21(3), 463–469. https://doi.org/10.1007/s00586-011-2038-5
De Iure, F., Cappuccio, M., Paderni, S., Bosco, G., & Amendola, L. (2012). Minimal invasive percutaneous fixation of thoracic and lumbar spine fractures. Minimally Invasive Surgery, 2012, e141032. https://doi.org/10.1155/2012/141032
Court, C., & Vincent, C. (2012). Percutaneous fixation of thoracolumbar fractures: Current concepts. Orthopaedics & Traumatology, Surgery & Research: OTSR, 98(8), 900–909. https://doi.org/10.1016/j.otsr.2012.09.014
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Ifthekar, S., Ahuja, K., Mittal, S. et al. Outcomes of Dorsolumbar and Lumbar Spinal Tuberculosis Treated by Minimally Invasive and Open Techniques: A Prospective Comparative Study. JOIO (2024). https://doi.org/10.1007/s43465-024-01123-5
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DOI: https://doi.org/10.1007/s43465-024-01123-5