Abstract
Background
Total knee arthroplasty (TKA) for Charcot arthropathy of the knee is considered controversial because of its higher complication rate compared with that of TKA for osteoarthritis. In this study, we investigated the clinical outcomes, survival rates, and complications of primary TKA for Charcot arthropathy.
Methods
We conducted a retrospective analysis of nine patients (12 knees) with Charcot arthropathy who underwent TKA. The mean age of the patients was 63.9 ± 9.4 years (range, 52–83 years). The most frequent causative disease was diabetes mellitus (three patients). Patients’ clinical outcomes, including the 2011 Knee Society Score and the range of motion, were compared between preoperative and the most recent postoperative data. The 5- and 10-year survival rates for aseptic revision, revision due to infection, and complications were examined. The mean follow-up period was 7.3 ± 3.9 years (range, 3–14 years).
Results
The 2011 Knee Society Score and the knee flexion angle significantly improved after TKA surgery (P < 0.05). The 5-year survival rates for aseptic revision, revision due to infection, and complications were 100%, 91.7%, and 83.3%, respectively; the 10-year survival rates for these parameters were the same. One patient underwent revision for insert replacement due to periprosthetic infection, and the other patient had varus/valgus instability due to soft tissue loosening.
Conclusions
The mid- to long-term results of TKA for Charcot arthropathy were generally favorable. Our findings indicate that TKA may be a viable treatment option for Charcot arthropathy.
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Data Availability
Raw data were generated at Kobe University Graduate School of Medicine. Derived data supporting the findings of this study are available from the corresponding author Tomoyuki Matsumoto on request.
References
Babazadeh, S., Stoney, J. D., Lim, K., & Choong, P. F. M. (2010). Arthroplasty of a Charcot knee. Orthopedic Reviews, 2(2), 17.
Kucera, T., Urban, K., & Sponer, P. (2011). Charcot arthropathy of the knee: A case-based review. Clin Rheumatol, 30(3), 425–428.
Illgner, U., Van Netten, J., Droste, C., Postema, K., Meiners, T., & Wetz, H. H. (2014). Diabetic charcot neuroarthropathy of the knee: Conservative treatment options as alternatives to surgery. Diabetes Care, 37(6), e129.
Kim, Y. H., Kim, J. S., & Oh, S. W. (2002). Total knee arthroplasty in neuropathic arthropathy. Journal of Bone and Joint Surgery. British Volume, 84(2), 216–219.
Yang, J. H., Yoon, J. R., Oh, C. H., & Kim, T. S. (2012). Primary total knee arthroplasty using rotating-hinge prosthesis in severely affected knees. Knee Surgery, Sports Traumatology, Arthroscopy, 20(3), 517–523.
Parvizi, J., Marrs, J., & Morrey, B. F. (2003). Total knee arthroplasty for neuropathic (Charcot) joints. Clinical Orthopaedics and Related Research, 416, 145–150.
Zeng, M., Xie, J., & Hu, Y. (2016). Total knee arthroplasty in patients with Charcot joints. Knee Surgery, Sports Traumatology, Arthroscopy, 24(8), 2672–2677.
Tibbo, M. E., Chalmers, B. P., Berry, D. J., Pagnano, M. W., Lewallen, D. G., & Abdel, M. P. (2018). Primary total knee arthroplasty in patients with neuropathic (Charcot) arthropathy: contemporary results. Journal of Arthroplasty, 33(9), 2815–2820.
Bae, D. K., Song, S. J., Yoon, K. H., & Noh, J. H. (2009). Long-term outcome of total knee arthroplasty in Charcot joint: A 10- to 22-year follow-up. Journal of Arthroplasty, 24(8), 1152–1156.
Noble, P. C., Scuderi, G. R., Brekke, A. C., Sikorskii, A., Benjamin, J. B., Lonner, J. H., Chadha, P., Daylamani, D. A., Scott, W. N., & Bourne, R. B. (2012). Development of a new knee society scoring system. Clinical Orthopaedics and Related Research, 470, 20–32.
Koshino, T. (1991). Stage classifications, types of joint destruction, and bone scintigraphy in Charcot joint disease. Bulletin of the Hospital for Joint Diseases Orthopaedic Institute, 51(2), 205–217.
Ewald, F. C. (1989). The Knee Society total knee arthroplasty roentgenographic evaluation and scoring system. Clinical Orthopaedics and Related Research, 248, 9–12.
Kanda, Y. (2013). Investigation of the freely available easy-to-use software “EZR” for medical statistics. Bone Marrow Transplantation, 48(3), 452–458.
Kishore, J., Goel, M., & Khanna, P. (2010). Understanding survival analysis: Kaplan-Meier estimate. Int J Ayurveda Res, 1(4), 274.
Runner, R. P., Bellamy, J. L., Vu, C. C. L., Erens, G. A., Schenker, M. L., & Guild, G. N. (2017). Modified frailty index is an effective risk assessment tool in primary total knee arthroplasty. Journal of Arthroplasty, 32(9), S177–S182.
Kunutsor, S. K., Whitehouse, M. R., Blom, A. W., & Beswick, A. D. (2016). Patient-related risk factors for periprosthetic joint infection after total joint arthroplasty: A systematic review and meta-analysis. PLoS One, 11(3), e0150866.
Morgan, H., Battista, V., & Leopold, S. S. (2005). Constraint in primary total knee arthroplasty. Journal of American Academy of Orthopaedic Surgeons, 13(8), 515–524.
Yilmaz, S., Cankaya, D., Deveci, A., First, A., Ozkurt, B., & Bozkurt, M. (2016). The impact of joint line restoration on functional results after hinged knee prosthesis. Indian Journal of Orthopaedics, 50, 136–145.
Nakajima, A., Tsuge, S., Aoki, Y., Sonobe, M., Shibata, Y., Sasaki, Y., & Nakagawa, K. (2013). Intra-articular giant heterotopic ossification following total knee arthroplasty for Charcot arthropathy. Case Reports in Orthopedics, 2013, 1–4.
Yasin, M. N., Charalambous, C. P., Mills, S. P., Phaltankar, P. M., & Nurron, R. W. (2011). Early failure of a knee replacement in a neuropathic joint: A case report. Acta Orthop Belg, 77(1), 132–136.
Yoshino, S., Fujimori, J., Kajino, A., Kiowa, M., & Uchida, S. (1993). Total knee arthroplasty in Charcot’s joint. Journal of Arthroplasty, 8(3), 335–340.
Whiteside, L. A. (1995). Exposure in difficult total knee arthroplasty using tibial tubercle osteotomy. Clinical Orthopaedics and Related Research, 321, 32–35.
Troyer, J., & Levine, B. R. (2009). Proximal tibia reconstruction with a porous tantalum cone in a patient with Charcot arthropathy. Orthopedics, 32(5), 358.
Love, B., Alexander, B., Ray, J., Halstrom, J., Barranco, H., Solar, S., Singh, M., & Shah, A. (2020). Outcomes of tibiocalcaneal arthrodesis in high-risk patients: An institutional cohort of 18 patients. Indian Journal of Orthopaedics, 54(1), 14–21.
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Onoi, Y., Matsumoto, T., Nakano, N. et al. Mid- to Long-Term Results of Total Knee Arthroplasty for Charcot Arthropathy of the Knee. JOIO 58, 308–315 (2024). https://doi.org/10.1007/s43465-023-01094-z
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DOI: https://doi.org/10.1007/s43465-023-01094-z