Abstract
Background
Evaluation of the ortho-anesthetic geriatric care pathway for patients with proximal femur fracture in a tertiary care referral center was done by reporting the peri-operative morbidity and mortality. Clinical and demographic predictors of mortality were also identified in this cohort.
Material and Methods
This prospective observational study was conducted between August 2017 and November 2018. Demographic, anesthetic and surgical characteristics were recorded. Telephonic post-discharge follow-up was done for a period of 2 years. Factors predicting mortality were estimated using multivariate logistic regression.
Results
The cohort was characterized by frailty, high ASA physical status, NYHA class and Charlson co-morbidity index. The delay in presentation to hospital and subsequent surgical fixation was 7 (1–8) and 8 (5–13) days, respectively. The 30, 60, 90-day, 1-year and 2-year mortality was 13.6%, 21.8%, 25.45%, 36.5% and 44%, respectively. Intra-operative blood transfusion was a predictor of 30-day mortality (OR 9.2, 95% CI 1.02–83.17; p = 0.048). Pre-operative respiratory dysfunction predicted 60-day (OR 11.245, 95% CI 1.38–91.58; p = 0.024) and 90-day (OR 11.654, 95% CI 1.91–71.1; p = 0.008) mortality. Post-operative morbidity was reported in 31 (28.1%) patients; incidence of pneumonia (n = 9), sepsis (n = 8), MI (n = 6), PTE (n = 5) and ARF (n = 3) were 8.18%, 7.27%, 5.45%, 4.54% and 2.72%, respectively.
Conclusion
Existing pathway facilitated surgical fixation with median delay of 8 days which should be shortened to 48 h. High mortality in our cohort needs to be decreased by preventing admission delays and aggressively managing co-morbidities. Acceptable benchmark goals for pre-operative optimization of lung disease and decrease in intra-operative blood transfusion need to be incorporated in existing care pathway.
Similar content being viewed by others
Data Availability
Data is available and it will be shared when asked by the journal.
References
Dhanwal, D. K., Siwach, R., Dixit, V., Mithal, A., Jameson, K., & Cooper, C. (2013). Incidence of hip fracture in Rohtak district, North India. Archives of Osteoporosis, 8, 135.
Bhan, N., Madhira, P., Muralidharan, A., Kulkarni, B., Murthy, G., Basu, S., & Kinra, S. (2017). Health needs, access to healthcare, and perceptions of ageing in an urbanizing community in India: a qualitative study. BMC Geriatrics, 17(1), 156.
Dey S, Nambiar D, Lakshmi JK, Sheikh K, Reddy KS (2012) Health of the elderly in India: challenges of access and affordability [Internet]. aging in Asia: findings from new and emerging data initiatives. National Academies Press. https://www.ncbi.nlm.nih.gov/books/NBK109208/. Cited 25 Nov 2022
Verma, R., & Khanna, P. (2013). National program of health-care for the elderly in India: a hope for healthy ageing. International Journal of Preventive Medicine, 4(10), 1103–1107.
Geriatric health care in India—unmet needs and the way forward Adhikari P. Arch Med Health Sci [Internet]. https://www.amhsjournal.org/article.asp?issn=2321-4848;year=2017;volume=5;issue=1;spage=112;epage=114;aulast=Adhikari. Cited 25 Nov 2022
Partridge, J. S. L., Harari, D., Martin, F. C., & Dhesi, J. K. (2014). The impact of pre-operative comprehensive geriatric assessment on postoperative outcomes in older patients undergoing scheduled surgery: a systematic review. Anaesthesia, 69(Suppl 1), 8–16.
Rath, S., Yadav, L., Tewari, A., Chantler, T., Woodward, M., Kotwal, P., Jain, A., Dey, A., Garg, B., Malhotra, R., Goel, A., Farooque, K., Sharma, V., Webster, P., & Norton, R. (2017). Management of older adults with hip fractures in India: a mixed methods study of current practice, barriers and facilitators, with recommendations to improve care pathways. Arch Osteopor, 12(1), 55.
Goldacre, M. J., Roberts, S. E., & Yeates, D. (2002). Mortality after admission to hospital with fractured neck of femur: database study. BMJ, 325(7369), 868–869.
Ram, G. G., & Govardhan, P. (2019). In-hospital mortality following proximal femur fractures in elderly population. Surg J (N Y)., 5(2), e53–e56.
Neuhaus, V., King, J., Hageman, M. G., & Ring, D. C. (2013). Charlson comorbidity indices and in-hospital deaths in patients with hip fractures. Clinical Orthopaedics and Related Research, 471(5), 1712–1719.
Chen, X., Mao, G., & Leng, S. X. (2014). Frailty syndrome: an overview. Clin Interv Aging [Internet], 19(9), 433–441. https://pubmed.ncbi.nlm.nih.gov/24672230/. Cited 25 Nov 2022
Kennedy, G. E. M., Mohandas, P., Anderson, L. A., Kennedy, M., & Shirley, D. S. L. (2020). Improving identification of cognitive impairment in fragility fracture patients: impact of educational guidelines on current practice. Geriatr Orthop Surg Rehabil, 11, 2151459320935095.
Jain, D., Sidhu, G. S., Selhi, H. S., Mears, S. C., Yamin, M., Mahindra, P., & Pannu, H. S. (2015). Early results of a geriatric hip fracture program in India for femoral neck fracture. Geriatr Orthop Surg Rehabil, 6(1), 42–46.
Marya, S. K. S., Thukral, R., & Singh, C. (2008). Prosthetic replacement in femoral neck fracture in the elderly: results and review of the literature. Indian J Orthop., 42(1), 61–67.
Schnell, S., Friedman, S. M., Mendelson, D. A., Bingham, K. W., & Kates, S. L. (2010). The 1-year mortality of patients treated in a hip fracture program for elders. Geriatr Orthop Surg Rehabil, 1(1), 6–14.
Grimes, J. P., Gregory, P. M., Noveck, H., Butler, M. S., & Carson, J. L. (2002). The effects of time-to-surgery on mortality and morbidity in patients following hip fracture. American Journal of Medicine, 112(9), 702–709.
Shiga, T., Wajima, Z., & Ohe, Y. (2008). Is operative delay associated with increased mortality of hip fracture patients? Systematic review, meta-analysis, and meta-regression. Canadian Journal of Anaesthesia, 55(3), 146–154.
Glance, L. G., Dick, A. W., Mukamel, D. B., Fleming, F. J., Zollo, R. A., Wissler, R., Salloum, R., Meredith, U. W., & Osler, T. M. (2011). Association between intraoperative blood transfusion and mortality and morbidity in patients undergoing noncardiac surgery. Anesthesiology, 114(2), 283–292.
de Luise, C., Brimacombe, M., Pedersen, L., & Sørensen, H. T. (2008). Chronic obstructive pulmonary disease and mortality following hip fracture: a population-based cohort study. European Journal of Epidemiology, 23(2), 115–122.
Metani, H., Tsubahara, A., Hiraoka, T., Seki, S., & Hasegawa, T. (2015). Risk factors for patients who develop pneumonia either before or after hip fracture surgery. JJCRS., 6, 43–49.
White, S. M., Moppett, I. K., Griffiths, R., Johansen, A., Wakeman, R., Boulton, C., Plant, F., Williams, A., Pappenheim, K., Majeed, A., Currie, C. T., & Grocott, M. P. W. (2016). Secondary analysis of outcomes after 11,085 hip fracture operations from the prospective UK Anaesthesia Sprint Audit of Practice (ASAP-2). Anaesthesia, 71(5), 506–514.
Saket, R., Aggarwal, S., Kumar, V., Kumar, P., & Patel, S. (2019). Acute venous thromboembolism in Indian patients of isolated proximal femur fractures. J Clin Orthop Trauma, 10(5), 917–921.
Ji, C., Zhu, Y., Liu, S., Li, J., Zhang, F., Chen, W., & Zhang, Y. (2019). Incidence and risk of surgical site infection after adult femoral neck fractures treated by surgery: a retrospective case-control study. Medicine (Baltimore), 98(11), e14882.
Westberg, M., Snorrason, F., & Frihagen, F. (2013). Preoperative waiting time increased the risk of periprosthetic infection in patients with femoral neck fracture. Acta Orthopaedica, 84(2), 124–129.
HIP Attack Investigators. (2020). Accelerated surgery versus standard care in hip fracture (HIP ATTACK): an international, randomised, controlled trial. Lancet, 395(10225), 698–708.
Acknowledgements
We would like to thank all the patients who participated in this study.
Author information
Authors and Affiliations
Contributions
All authors contributed to the study conception and design. TS and NN performed material preparation, data collection, and analysis. The first draft of the manuscript was written by TS. All authors read and approved the final manuscript.
Corresponding author
Ethics declarations
Conflicts of interest
All the authors declare no potential conflicts of interest (financial or non-financial).
Informed consent
Informed consent to participate in the study was provided by participants.
Ethical approval
Approved by the Institute ethics committee (NK/3836/MD/499 dated 29–10–2017) and registered in clinical trials registry (India) CTRI/2018/03/012853 on 23–3–2018.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Name of the institution where work was performed: Advanced trauma centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Samra, T., Jain, K., Kaushal, V. et al. The Outcome of Surgically Treated Proximal Femur Fractures Managed by Ortho-anesthetic Geriatric Care Pathway: A Prospective Observational Study with 2-Year Follow-Up. JOIO 57, 957–966 (2023). https://doi.org/10.1007/s43465-023-00880-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s43465-023-00880-z