Skip to main content

Advertisement

SpringerLink
Log in

Extranodal Diffuse Large B-Cell Lymphoma (DLBCL) Presenting as Diffuse Joint Pain: A Diagnostic Dilemma

  • Case Report
  • Published:
Indian Journal of Orthopaedics Aims and scope Submit manuscript

Abstract

Diffuse Large B-Cell Lymphoma (DLBCL) of bone is a rare presentation of Non-Hodgkin Lymphoma (NHL), which remains asymptomatic or present late in clinical course as bone pain or pathological fracture. We report a case of a 15-year-old male child presenting with diffuse joint pain and swelling over his left shoulder and elbow, associated with B symptoms. Radiological examination revealed lytic lesions in multiple bones along with collection along the left iliopsoas and hip joint, suggestive of infective etiology. The diagnostic dilemma was resolved on biopsy, which confirmed DLBCL involving bones and soft tissue.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

Data availability

Data can be made available by direct correspondance with the corresponding author, through the respective departments involved in the study, after explicitly mentioning the reason and intended purpose of the demand.

References

  1. de Leval, L., Braaten, K. M., Ancukiewicz, M., Kiggundu, E., Delaney, T., Mankin, H. J., et al. (2003). Diffuse large B-cell lymphoma of bone: An analysis of differentiation-associated antigens with clinical correlation. American Journal of Surgical Pathology, 27(9), 1269–1277.

    Article  PubMed  Google Scholar 

  2. Swerdlow, S. H., Campo, E., Harris, N. L., Jaffe, E. S., Pileri, S. A., Stein, H., et al. WHO classification of tumours of haematopoietic and lymphoid tissues: International agency for research on cancer Lyon; 2008.

  3. Chisholm, K. M., Ohgami, R. S., Tan, B., Hasserjian, R. P., & Weinberg, O. K. (2017). Primary lymphoma of bone in the pediatric and young adult population. Human Pathology, 60, 1–10.

    Article  PubMed  Google Scholar 

  4. Suo, H., Fu, L., Wang, Z., Liang, H., Xu, Z., & Feng, W. (2020). Primary lymphoma of the tibia in children: Two case reports. Medicine (Baltimore), 99(4), e18807.

    Article  PubMed  Google Scholar 

  5. Muller, A., Dreyling, M., Roeder, F., Baur-Melnyk, A., Knosel, T., Klein, A., et al. (2020). Primary bone lymphoma: Clinical presentation and therapeutic considerations. J Bone Oncol., 25, 100326.

    Article  PubMed  PubMed Central  Google Scholar 

  6. McCammon, J., Mascarenhas, R., Monument, M. J., Elyousfi, A., & Pilkey, B. (2014). Large B-cell lymphoma mimicking iliopsoas abscess following open revision of proximal femur infected non-union: A case report. BMC Research Notes, 7, 470.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Mandal, P. K., Baul, S., & Dolai, T. K. (2015). Primary bone lymphoma with multifocal osteolytic lesions: A rare case report with review of literature. Blood Res., 50(4), 256–260.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Orthopaedic Surgery, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, 202002, India

    Abdul Qayyum Khan, Rayed Qamar, Madhav Chowdhry, Saad Mohammad Khan & Divas Gupta

  2. Department of Pathology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, 202002, India

    Bushra Siddiqui

Authors
  1. Abdul Qayyum Khan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rayed Qamar
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Madhav Chowdhry
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Bushra Siddiqui
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Saad Mohammad Khan
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Divas Gupta
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Madhav Chowdhry.

Ethics declarations

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Ethical Standard Statement

This article does not contain any studies with human or animal subjects performed by the any of the authors.

Informed Consent

For this type of study, informed consent is not required.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Khan, A.Q., Qamar, R., Chowdhry, M. et al. Extranodal Diffuse Large B-Cell Lymphoma (DLBCL) Presenting as Diffuse Joint Pain: A Diagnostic Dilemma. JOIO 57, 603–607 (2023). https://doi.org/10.1007/s43465-023-00831-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s43465-023-00831-8

Keywords

Search

Navigation