Gold-Induced Cytokine (GOLDIC®) Injection Therapy in Patient with Plantar Fasciosis: A Case Report

Abstract

A novel technique of cultivating autologous blood with gold particles; then separating the gold particles and cells from the serum and injecting the conditioned serum into affected plantar fascia. A first-time report of the safety and efficacy in treatment of recalcitrant plantar fasciosis in an Olympic equestrian. A single patient with clinical signs, symptoms and ultrasound evidence of plantar fasciosis was treated with four intra-ligamentous GOLDIC® injection therapy. The Olympic jumper was evaluated by Visual Analog Scale (VAS), Foot and Ankle Disability Index (FADI), and Global Rating of Change (GRoC) score(s) before injection and at 6-month follow-up. VAS, FADI, and GRoC scores showed substantial and marked improvement clinically. The subject was able to return to sport without limitations after 8 weeks. The initial result demonstrates that the treatment regimen is safe, and efficacious. The subject demonstrated reduction of pain, and improved function that allowed return to high level competition.

This is a preview of subscription content, access via your institution.

Fig. 1
Fig. 2

References

  1. 1.

    Singh, D., Angel, J., Bentley, G., & Trevino, S. G. (1997). Fortnightly review: plantar fasciitis. BMJ,19(315), 172–175.

    Article  Google Scholar 

  2. 2.

    Lemont, H., Ammirati, K. M., & Usen, N. (2003). Plantar fasciitis: a degenerative process (Fasciosis) without inflammation. Journal of the American Podiatric Medical Association,93, 234–237.

    Article  Google Scholar 

  3. 3.

    DeMaio, M., Paine, R., Mangine, R. E., & Drez, D. (1993). Plantar fasciitis. Orthopedics,16, 1153–1163.

    CAS  PubMed  Google Scholar 

  4. 4.

    Young, J. D., Gelbs, J. C., Zhu, D. S., Gallacher, S. E., Sutton, K. M., & Blaine, T. A. (2015). Orthopaedic injuries in equestrian sports: a current concepts review. Orthopaedic Journal of Sports Medicine,3, 1–7.

    Article  Google Scholar 

  5. 5.

    McCrory, P., & Turner, M. (2005). Equestrian injuries, in epidemiology of pediatric sports injuries Individual Sports. In D. J. Caine & N. Maffulli (Eds.), Med Sport Sci (Vol. 48, pp. 8–17). Basel: Karger.

    Google Scholar 

  6. 6.

    Wearing, S. C., Smeathers, J. E., Urry, S. R., Hennig, E. M., & Hills, A. P. (2006). The pathomechanics of plantar fasciitis. Sport Medicine,36, 585–611.

    Article  Google Scholar 

  7. 7.

    Rome, K. (1997). Anthropometric and biomechanical risk factors in the development of plantar heel pain—a review of the literature. Physical Therapy Reviews,2, 123–134.

    Article  Google Scholar 

  8. 8.

    Irving, D. B., Cook, J. L., Young, M. A., & Menz, H. B. (2007). Obesity and pronated foot type may increase the risk of chronic plantar heel pain: a matched case-control study. BMC Musculoskeletal Disorders,17(8), 41.

    Article  Google Scholar 

  9. 9.

    Schepsis, A. A., Leach, R. E., & Gorzyca, J. (1991). Plantar fasciitis: etiology, treatment, surgical results, and review of the literature. Clinical Orthopaedics and Related Research,266, 185–196.

    Google Scholar 

  10. 10.

    Gill, L. H. (1997). Plantar fasciitis: diagnosis and conservative management. Journal of American Academy of Orthopaedic Surgeons,5, 109–117.

    CAS  Article  Google Scholar 

  11. 11.

    Pugh, T. J., & Bolin, D. (2004). Overuse injuries in equestrian athletes. Current Sports Medicine Reports,3, 297–303.

    PubMed  Google Scholar 

  12. 12.

    Atkins, D., Crawford, F., Edwards, J., & Lambert, M. (1999). A systematic review of treatments for the painful heel. Rheumatology,38, 968–973.

    CAS  Article  Google Scholar 

  13. 13.

    Rompe, J. D., Furia, J., Weil, L., & Maffulli, N. (2007). Shock wave therapy for chronic plantar fasciopathy. British Medical Bulletin,81–82, 183–208.

    Article  Google Scholar 

  14. 14.

    Hsiao, M. Y., Hung, C. Y., Chang, K. V., Chien, K. L., Tu, Y. K., & Wang, T. G. (2015). Comparative effectiveness of autologous blood-derived products, shock-wave therapy and corticosteroids for treatment of plantar fasciitis: a network meta-analysis. Rheumatology,54, 1735–1743.

    CAS  Article  Google Scholar 

  15. 15.

    Schneider, U., Wallich, R., Felmet, G., & Murrell, W.D. (2017). Gold-induced autologous cytokine treatment in Achilles tendinopathy. In: G. Canata, P. d'Hooghe, & K. Hunt (Eds.), Muscle and Tendon Injuries. Berlin, Heidelberg: Springer.

    Google Scholar 

Download references

Acknowledgements

Pam Jackson, Ph.D., for manuscript review.

Author information

Affiliations

Authors

Corresponding author

Correspondence to William D. Murrell.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical standard statement

This article does not contain any studies with human or animal subjects performed by the any of the authors.

Informed consent

For this type of study informed consent is not required.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Melo, S.N.S., Ezekwesili, A., Yurdi, N.A. et al. Gold-Induced Cytokine (GOLDIC®) Injection Therapy in Patient with Plantar Fasciosis: A Case Report. JOIO 54, 348–351 (2020). https://doi.org/10.1007/s43465-020-00089-4

Download citation

Keywords

  • Plantar fasciitis
  • Goldic
  • Intra-ligamentous injection
  • Pain Relief
  • Functional Score
  • PRP
  • ACS
  • Regenokine
  • Orthokine
  • ACP
  • Injections
  • Regenerative medicine
  • Pain management
  • Translational medical research
  • Humans
  • Fascia pathology
  • Fascia injuries
  • Fasciitis. Plantar/etiology
  • Fasciitis. Plantar/physiopathology