Skip to main content

Advertisement

SpringerLink
Log in

Gold-Induced Cytokine (GOLDIC®) Injection Therapy in Patient with Plantar Fasciosis: A Case Report

  • Case Report
  • Published:
Indian Journal of Orthopaedics Aims and scope Submit manuscript

Abstract

A novel technique of cultivating autologous blood with gold particles; then separating the gold particles and cells from the serum and injecting the conditioned serum into affected plantar fascia. A first-time report of the safety and efficacy in treatment of recalcitrant plantar fasciosis in an Olympic equestrian. A single patient with clinical signs, symptoms and ultrasound evidence of plantar fasciosis was treated with four intra-ligamentous GOLDIC® injection therapy. The Olympic jumper was evaluated by Visual Analog Scale (VAS), Foot and Ankle Disability Index (FADI), and Global Rating of Change (GRoC) score(s) before injection and at 6-month follow-up. VAS, FADI, and GRoC scores showed substantial and marked improvement clinically. The subject was able to return to sport without limitations after 8 weeks. The initial result demonstrates that the treatment regimen is safe, and efficacious. The subject demonstrated reduction of pain, and improved function that allowed return to high level competition.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Singh, D., Angel, J., Bentley, G., & Trevino, S. G. (1997). Fortnightly review: plantar fasciitis. BMJ,19(315), 172–175.

    Article  Google Scholar 

  2. Lemont, H., Ammirati, K. M., & Usen, N. (2003). Plantar fasciitis: a degenerative process (Fasciosis) without inflammation. Journal of the American Podiatric Medical Association,93, 234–237.

    Article  Google Scholar 

  3. DeMaio, M., Paine, R., Mangine, R. E., & Drez, D. (1993). Plantar fasciitis. Orthopedics,16, 1153–1163.

    CAS  PubMed  Google Scholar 

  4. Young, J. D., Gelbs, J. C., Zhu, D. S., Gallacher, S. E., Sutton, K. M., & Blaine, T. A. (2015). Orthopaedic injuries in equestrian sports: a current concepts review. Orthopaedic Journal of Sports Medicine,3, 1–7.

    Article  Google Scholar 

  5. McCrory, P., & Turner, M. (2005). Equestrian injuries, in epidemiology of pediatric sports injuries Individual Sports. In D. J. Caine & N. Maffulli (Eds.), Med Sport Sci (Vol. 48, pp. 8–17). Basel: Karger.

    Google Scholar 

  6. Wearing, S. C., Smeathers, J. E., Urry, S. R., Hennig, E. M., & Hills, A. P. (2006). The pathomechanics of plantar fasciitis. Sport Medicine,36, 585–611.

    Article  Google Scholar 

  7. Rome, K. (1997). Anthropometric and biomechanical risk factors in the development of plantar heel pain—a review of the literature. Physical Therapy Reviews,2, 123–134.

    Article  Google Scholar 

  8. Irving, D. B., Cook, J. L., Young, M. A., & Menz, H. B. (2007). Obesity and pronated foot type may increase the risk of chronic plantar heel pain: a matched case-control study. BMC Musculoskeletal Disorders,17(8), 41.

    Article  Google Scholar 

  9. Schepsis, A. A., Leach, R. E., & Gorzyca, J. (1991). Plantar fasciitis: etiology, treatment, surgical results, and review of the literature. Clinical Orthopaedics and Related Research,266, 185–196.

    Google Scholar 

  10. Gill, L. H. (1997). Plantar fasciitis: diagnosis and conservative management. Journal of American Academy of Orthopaedic Surgeons,5, 109–117.

    Article  CAS  Google Scholar 

  11. Pugh, T. J., & Bolin, D. (2004). Overuse injuries in equestrian athletes. Current Sports Medicine Reports,3, 297–303.

    PubMed  Google Scholar 

  12. Atkins, D., Crawford, F., Edwards, J., & Lambert, M. (1999). A systematic review of treatments for the painful heel. Rheumatology,38, 968–973.

    Article  CAS  Google Scholar 

  13. Rompe, J. D., Furia, J., Weil, L., & Maffulli, N. (2007). Shock wave therapy for chronic plantar fasciopathy. British Medical Bulletin,81–82, 183–208.

    Article  Google Scholar 

  14. Hsiao, M. Y., Hung, C. Y., Chang, K. V., Chien, K. L., Tu, Y. K., & Wang, T. G. (2015). Comparative effectiveness of autologous blood-derived products, shock-wave therapy and corticosteroids for treatment of plantar fasciitis: a network meta-analysis. Rheumatology,54, 1735–1743.

    Article  CAS  Google Scholar 

  15. Schneider, U., Wallich, R., Felmet, G., & Murrell, W.D. (2017). Gold-induced autologous cytokine treatment in Achilles tendinopathy. In: G. Canata, P. d'Hooghe, & K. Hunt (Eds.), Muscle and Tendon Injuries. Berlin, Heidelberg: Springer.

    Google Scholar 

Download references

Acknowledgements

Pam Jackson, Ph.D., for manuscript review.

Author information

Author notes

  1. Sergio Nicolas Sardon Melo and William D. Murrell equally contributors.

Authors and Affiliations

  1. Emirates Integra Medical and Emirates Integra Medical and Surgery and Surgery Centre, Department Orthopaedic Sports Medicine, Dubai Healthcare City, Dubai, United Arab Emirates

    Sergio Nicolas Sardon Melo

  2. University of North Carolina, Chapel Hill, NC, USA

    Agnes Ezekwesili

  3. Healthpoint Hospital, Abu Dhabi, United Arab Emirates

    Nagib A. Yurdi & William D. Murrell

  4. Division of Surgery, Department of Orthopedic Surgery, Landstuhl Regional Medical Center, Landstuhl, Germany

    William D. Murrell

  5. Department of Musculoskeletal Disorders, School of Medicine and Dentistry, University of Salerno, Salerno, Italy

    Nicola Maffulli

  6. Queen Mary University of London, Barts and the London School of Medicine and Dentistry Centre for Sports and Exercise Medicine, Mile End Hospital, London, England, UK

    Nicola Maffulli

Authors
  1. Sergio Nicolas Sardon Melo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Agnes Ezekwesili
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nagib A. Yurdi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. William D. Murrell
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Nicola Maffulli
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to William D. Murrell.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical standard statement

This article does not contain any studies with human or animal subjects performed by the any of the authors.

Informed consent

For this type of study informed consent is not required.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Melo, S.N.S., Ezekwesili, A., Yurdi, N.A. et al. Gold-Induced Cytokine (GOLDIC®) Injection Therapy in Patient with Plantar Fasciosis: A Case Report. JOIO 54, 348–351 (2020). https://doi.org/10.1007/s43465-020-00089-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s43465-020-00089-4

Keywords

Search

Navigation