Gold-Induced Cytokine (GOLDIC®) Injection Therapy in Patient with Plantar Fasciosis: A Case Report


A novel technique of cultivating autologous blood with gold particles; then separating the gold particles and cells from the serum and injecting the conditioned serum into affected plantar fascia. A first-time report of the safety and efficacy in treatment of recalcitrant plantar fasciosis in an Olympic equestrian. A single patient with clinical signs, symptoms and ultrasound evidence of plantar fasciosis was treated with four intra-ligamentous GOLDIC® injection therapy. The Olympic jumper was evaluated by Visual Analog Scale (VAS), Foot and Ankle Disability Index (FADI), and Global Rating of Change (GRoC) score(s) before injection and at 6-month follow-up. VAS, FADI, and GRoC scores showed substantial and marked improvement clinically. The subject was able to return to sport without limitations after 8 weeks. The initial result demonstrates that the treatment regimen is safe, and efficacious. The subject demonstrated reduction of pain, and improved function that allowed return to high level competition.

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Pam Jackson, Ph.D., for manuscript review.

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Correspondence to William D. Murrell.

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Melo, S.N.S., Ezekwesili, A., Yurdi, N.A. et al. Gold-Induced Cytokine (GOLDIC®) Injection Therapy in Patient with Plantar Fasciosis: A Case Report. JOIO 54, 348–351 (2020).

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  • Plantar fasciitis
  • Goldic
  • Intra-ligamentous injection
  • Pain Relief
  • Functional Score
  • PRP
  • ACS
  • Regenokine
  • Orthokine
  • ACP
  • Injections
  • Regenerative medicine
  • Pain management
  • Translational medical research
  • Humans
  • Fascia pathology
  • Fascia injuries
  • Fasciitis. Plantar/etiology
  • Fasciitis. Plantar/physiopathology