Skip to main content
SpringerLink
Log in

Gastroprotective activity of punicalagin and Lafoensia pacari in mice

  • Short Communication
  • Published:
Revista Brasileira de Farmacognosia Aims and scope Submit manuscript

Abstract

Lafoensia pacari A. St.-Hil., Lythraceae, is used in Brazilian folk medicine to treat ulcer and gastritis; thus, it is important to conduct research so as to better understand its medicinal properties. The aim of this study was to assess the antisecretory and antiulcerogenic activities of lyophilized aqueous fraction and punicalagin isolated from leaves of L. pacari. Antisecretory gastric acid activity and antiulcerogenic activity were investigated by pyloric ligation-induced and indomethacin-induced gastric lesion models, respectively. Results show that the lyophilized aqueous fraction of L. pacari and punicalagin reduced the volume of gastric secretion, free acidity, and total acidity in mice 4 h after pyloric ligation, as well as the rate of gastric damage following the indomethacin administration model. Reduction percentages varied according to the dose of each treatment and showed statistical difference. This finding indicates that the lyophilized aqueous fraction of L. pacari and punicalagin exert an antiulcerogenic effect due to their acid antisecretory activity.

Graphical Abstract

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Cabral PRF, Pasa MC (2009) Mangava-brava: Lafoensia pacari a. St. - Hil. (Lythraceae) and the ethnobotany of Cuiabá, MT. Rev Biodiversidade 8:2–21

    Google Scholar 

  • Carneiro CC, Santos SC, Lino Junior RS, Bara MTF, Chaibub BA, Reis PRM, Chaves DA, Silva AJR, Silva LS, Silva DM, Chen-Chen L (2016) Chemopreventive effect and angiogenic activity of punicalagin isolated from leaves of Lafoensia pacari A. St.-Hil. Toxicol Appl Pharmacol 310:1–8

    Article  CAS  Google Scholar 

  • Djahanguiri B (1969) The production of aacute gastric ulceration by indomethacin in the rat. Scand J Gastroenterol 4:265–267

  • Galdino PM, Nascimento MVM, Sousa FB, Ferreira RN, Paula JR, Costa EA (2010) Central activities of hydroalcoholic extract from Lafoensia pacari a. St.-Hil. stem bark. Braz J Pharm Sci 46:455–462

    Article  Google Scholar 

  • Guimarães H, Nascimento MVM, Tavares A, Galdino PM, Paula JR, Costa EA (2010) Effects of ethanolic extract of leaves of Lafoensia pacari A. St.-Hil., Lythraceae (pacari), in pain and inflammation models. Rev Bras Farmacogn 20:328–333

    Article  Google Scholar 

  • Jesus NZT, Lima JCS, Silva RM, Espinosa MM, Martins DTO (2009) Ethnobotanical survey of plants popularly used as anti-ulcer and anti-inflammatory in Pirizal, Nossa Senhora do Livramento, MT, Brazil. Rev Bras Farmacogn 19:130–139

    Article  Google Scholar 

  • Martins JLR, Rodrigues ORL, Fajemiroye JO, Galdino PM, Florentino IF, Costa EA (2015) Medicinal species with gastroprotective activity found in the Brazilian Cerrado. Fundam Clin Pharmacol 29:238–251

    Article  CAS  Google Scholar 

  • Martins JLR, Sousa FB, Fajemiroye JO, Ghedini PC, Ferreira PM, Costa EA (2014) Anti-ulcerogenic and antisecretory effects of Celtis iguanaea (Jacq) Sargent hexane leaf extract. Rev Bras Farmacogn Pl Med 16:250–255

    Article  Google Scholar 

  • Muthuraman A, Soo S (2010) Antisecretory, antioxidative and antiapoptotic effects of montelukast on pyloric ligation and water immersion stress induced peptic ulcer in rat. Prostaglandins Leukot Essent Fat Acids 83:55–60

    Article  CAS  Google Scholar 

  • Nascimento MVM, Galdino PM, Florentino IF, Sampaio BL, Vanderlinde FA, Paula JR, Costa EA (2011) Antinociceptive effect of Lafoensia pacari A St-Hil independent of anti-inflammatory activity of ellagic acid. J Nat Med 65:448–454

    Article  CAS  Google Scholar 

  • Sampaio BL, Bara MTF, Ferri PH, Santos SC, Paula JR (2011) Influence of environmental factors on the concentration of phenolic compounds in leaves of Lafoensia pacari. Rev Bras Farmacogn 21:1127–1137

    Article  CAS  Google Scholar 

  • Silva TC, Zara ALSA, Sá FAS, Bara MTF, Avila RI, Costa CR, Valadares MC, Santos AS, Freitas VAQ, Silva MRR (2018) Antifungal potential of punicalagin against Cryptococcus neoformans species complex. Rev Inst Med Trop São Paulo 60:1–6

    Google Scholar 

  • Tamashiro Filho P, Olaitan BS, Almeida DAT, Lima JCS, Marson-Ascêncio PG, Ascêncio SD, Rios-Santos F, Martins DTO (2012) Evaluation of antiulcer activity and mechanism of action of methanol stem bark extract of Lafoensia pacari A. St.-Hil. (Lythraceae) in experimental animals. J Ethnopharmacol 144:497–505

    Article  CAS  Google Scholar 

  • Visscher FE, Seay PH, Tazelaar Junior AP, Veldkamp W, Vander Brook MJ (1954) Pharmacology of pamine bromide. J Pharmacol Exp Ther 110:188–204

    CAS  PubMed  Google Scholar 

Download references

Funding

The authors are grateful to Capes and CNPQ for the financial support provided.

Author information

Authors and Affiliations

  1. Faculdade de Farmácia, Universidade Federal de Goiás, Goiânia, GO, Brazil

    Beatriz A. Chaibub, José R. de Paula & Maria Teresa F. Bara

  2. Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, Brazil

    José L. R. Martins & Elson A. Costa

  3. Instituto de Química, Universidade Federal de Goiás, Goiânia, GO, Brazil

    Suzana da C. Santos

Authors
  1. Beatriz A. Chaibub
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. José L. R. Martins
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. José R. de Paula
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Suzana da C. Santos
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Elson A. Costa
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Maria Teresa F. Bara
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

BAC: acquisition, analysis, and interpretation of data. JLRM: acquisition of pharmacological data and statistical expertise. EAC: design of pharmacological tests and provision of materials. SCS: isolation of punicalagin. JRP: provision of materials. MTFB: study design, provision of materials, securing of funding, and writing of article.

Corresponding author

Correspondence to Maria Teresa F. Bara.

Ethics declarations

Conflict of Interest

The authors declare that they have no conflicts of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chaibub, B.A., Martins, J.L.R., de Paula, J.R. et al. Gastroprotective activity of punicalagin and Lafoensia pacari in mice. Rev. Bras. Farmacogn. 30, 423–426 (2020). https://doi.org/10.1007/s43450-020-00007-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s43450-020-00007-7

Keywords

Search

Navigation