The SARS-Cov-2 pandemic has left more than 40,000 deaths in Mexico ; this is probably because there is no effective treatment that can stop the coronavirus worldwide. Studies have been conducted with hydroxychloroquine in combination with azithromycin; however, this has not been successful . Studies have also been done with the antiparasitic Ivermectin, but the results are still controversial .
The use of antivirals has been approved by the FDA, such as Remdesivir , which is an adenosine nucleotide analogue that disrupts viral replication and inhibits the RNA polymerase enzyme. However, its use requires hospital assistance, since it is administered intravenously, which increases treatment costs due to hospital attention.
In 1973 amantadine was approved by the FDA for the treatment of motor symptoms in patients with Parkinson's disease . In 1976, amantadine was developed for the treatment of influenza H1N1 [6, 7]; however, this drug is not recommended for the treatment of influenza, because it mutates and loses sensitivity to the drug . Amantadine has been found to have several benefits, such as being used as an anti-parkinsonian, as it is involved in the process of dopamine release . It is important to note that patients with Parkinson's disease, who are being treated with amantadine, have not shown the symptomatology of COVID-19 infection [10, 11]. It is important to mention that the neurological indications of amantadine are not related to its antiviral activity.
Molecular docking studies have shown that amantadine could enter the SARS-Cov-2 E-channel and interfere with the release of its viral content into the cell, thus inhibiting its propagation . Other studies have shown that amantadine as a treatment for COVID-19 infection has been effective, and the patients have recovered successfully, without the necessity to go to a hospital .
In this observational study, 15 patients were treated in an ambulatory setting in Southern Mexico with amantadine, and it was shown to be effective for the successful recovery of SARS-Cov-2 infected patients.