Astrocytes are the most abundant glial cells in the central nervous system, and are important players in both brain injury and neurodegenerative disease. Curcumin (1,7-bis[4-hydroxy-3-methoxyphenyl]-1,6-heptadiene-3,5-dione), the major active component of turmeric, belongs to the curcuminoid family that was originally isolated from the plant Curcuma longa. Several studies suggest that curcumin may have a beneficial impact on the brain pathology and aging. These effects are due to curcumin’s antioxidant, free-radical scavenging, and anti-inflammatory activity. In light of this, our current review aims to discuss the role of astrocytes as essential players in neurodegenerative diseases and suggest that curcumin is capable of direct inhibition of astrocyte activity with a particular focus on its effects in Alexander disease, Alzheimer's disease, ischemia stroke, spinal cord injury, Multiple sclerosis, and Parkinson’s disease.
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Tumor necrosis factor
Mitogen-activated protein kinases
Ionized calcium binding adaptor molecule 1
Monocyte chemoattractant protein-1
Signal transducer and activator of transcription proteins
Matrix metallopeptidase 9
Interleukin 1 beta
- MIP-1 α:
Macrophage inflammatory protein-1 alpha
Macrophage inflammatory protein 2
The inducible transcription factor nuclear factor-kappa B
Regulated upon activation, normal T cell
Inducible nitric oxide synthase
Brain-derived neurotrophic factor
Cannabinoid receptor type 1
Glial fibrillary acidic protein
Mitogen-activated protein kinase
Extracellular signal-regulated kinase 2
The causative gene in Wolfram syndrome 2
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Muhammed Majeed is the founder of Sabinsa Corporation and Sami Labs Ltd. Other authors have no direct competing interests to declare.
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Eghbaliferiz, S., Farhadi, F., Barreto, G.E. et al. Effects of curcumin on neurological diseases: focus on astrocytes. Pharmacol. Rep 72, 769–782 (2020). https://doi.org/10.1007/s43440-020-00112-3
- Neurodegenerative disease