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Surgical outcome of scoliosis in patients with Marfan syndrome

Abstract

Purpose

To evaluate clinical and radiographic outcomes after surgical scoliosis correction and posterior instrumented fusion in SMF patients.

Methods

A single-center medical database was reviewed to identify MF patients who presented with scoliosis from 2000 to 2015. Patients who underwent spinal fusion surgery were included. Demographic, operative and clinical data were reviewed, and the preoperative, postoperative, and latest follow-up radiographic parameters were compared.

Results

Twelve patients were identified (2 males, 10 females) with an average age at surgery of 14.4 ± 2.6 years. Comorbidities were found in 84.6%. Most patients (90.9%) presented with a right thoracic curve. The average preoperative Cobb angle was 75.6 ± 15.5 degrees. Posterior instrumented spinal fusion was performed in all patients (1 hook/pedicular screw and 11 pedicle screws only). The average follow-up period was 6.8 ± 3.1 years. The mean postoperative Cobb angle after surgery and at the final follow-up was 33.4 ± 18.0 degrees and 35.5 ± 18.4 degrees, respectively. There was a statistically significant difference among the preoperative and postoperative Cobb angles (p < 0.001), but no significant difference among the sagittal angles. Two perioperative complications including superficial wound infection and broken rods were observed.

Conclusions

Posterior scoliosis correction and instrumented spinal fusion resulted in a satisfactory outcome in MF patients. Perioperative complications are not uncommon; however, no neurological complication or spinal decompensation was observed in this study.

Level of evidence

IV.

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Fig. 1
Fig. 2

Abbreviations

MF:

Marfan syndrome

SMF:

Marfan patients with scoliosis

AP:

Anteroposterior

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Acknowledgements

The authors gratefully acknowledge the staff of the Siriraj Orthopedic Research Unit, and Mr. Pongsathorn Samphaotong for his assistance with statistical analysis, manuscript preparation, and journal submission process.

Funding

No funding was received for conducting this study.

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Authors

Contributions

CC: Design and drafting of the work. Revising it critically for important intellectual content. Final approval of the version to be published. PV: Developed and verified the analytical methods. Final approval of the version to be published. TA: Design and drafting of the work. Final approval of the version to be published. MR: Developed and verified the analytical methods. Final approval of the version to be published. SW: Design and drafting of the work. Revising it critically for important intellectual content. Final approval of the version to be published. AC: Developed and verified the analytical methods. Final approval of the version to be published. ST: Revising it critically for important intellectual content. Final approval of the version to be published. BS: Revising it critically for important intellectual content. Writing the original draft of manuscript. Final approval of the version to be published. NA: Developed and verified the formal analysis. Administrative, technical or material support. Writing-review & editing manuscript. Final approval of the version to be published. PL: Design and drafting of the work. Develop and verified the analytical methods. Writing the original draft of manuscript. Final approval of the version to be published.

Corresponding author

Correspondence to Panya Luksanapruksa.

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The authors have no competing interests to declare that are relevant to the content of this article.

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The Siriraj Institutional Review Board (SIRB) (COA no. 201/2559(EC2)) approved this study.

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Cite this article

Chotigavanichaya, C., Vatidvarodom, P., Ariyawatkul, T. et al. Surgical outcome of scoliosis in patients with Marfan syndrome. Spine Deform (2022). https://doi.org/10.1007/s43390-022-00547-z

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  • DOI: https://doi.org/10.1007/s43390-022-00547-z

Keywords

  • Surgical outcome
  • Scoliosis
  • Marfan syndrome
  • Posterior spinal fusion