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Late spinal infections are more common after pediatric than after adult spinal deformity surgery

Abstract

Purpose

To compare the incidence, timing, and microbiologic factors associated with late spinal infection (onset ≥ 6 months after index operation) in pediatric versus adult spinal deformity patients who underwent instrumented posterior spinal fusion (PSF).

Methods

We retrospectively queried our institutional database for pediatric (aged ≤ 21 years) and adult patients who underwent instrumented PSF from 2000 to 2015. Inclusion criteria were > 12-month follow-up, spinal arthrodesis spanning 4 or more levels, and idiopathic or degenerative spinal deformity. We included 1260 patients (755 pediatric, 505 adult). Incidence, timing, and microbiologic and operative parameters of late spinal infections were compared using chi-squared and Fisher exact tests. Alpha = 0.05.

Results

Late spinal infection occurred in 28 (3.7%) pediatric and 2 (0.39%) adult patients (p = 0.009). Mean onset of infection was 4.2 years (range 0.7–12) in pediatric patients and 4.0 years (range 0.7–7.3) in adults (p = 0.93). Pediatric patients underwent arthrodesis spanning more levels (mean ± standard deviation, 10 ± 2.0) compared with adults (8.4 ± 3.3) (p < 0.001). Adults experienced greater intraoperative blood loss (2085 ± 1491 mL) compared with pediatric patients (796 ± 452 mL) (p < 0.001). Culture samples yielded positive growth in 11 pediatric and 2 adult cases. Propionibacterium and coagulase-negative staphylococci were the most commonly detected microorganisms in both cohorts.

Conclusion

Late spinal infections were significantly more common in pediatric patients than in adults after instrumented PSF for spinal deformity. Skin and indolent microorganisms were the primary identifiable causative bacteria in both cohorts.

Level of evidence

III.

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Fig. 1

Availability of data and material

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Code availability

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Acknowledgements

For their editorial assistance, we thank Jenni Weems, MS, Kerry Kennedy, BA, and Rachel Box, MS, in the Editorial Services group of The Johns Hopkins Department of Orthopaedic Surgery.

Funding

The authors received no financial support for the research, authorship, or publication of this article.

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II: data collection, writing-original draft preparation, and approval of final version of manuscript, agree to be accountable for the work. GJB: data collection, approval of final version of manuscript, agree to be accountable for the work. AM: approval of final version of manuscript, agree to be accountable for the work. AJ: approval of final version of manuscript, agree to be accountable for the work. KMK: approval of final version of manuscript, agree to be accountable for the work. PDS: writing-original draft preparation, and approval of final version of manuscript, agree to be accountable for the work.

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Correspondence to Paul D. Sponseller.

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This study was approved by The Johns Hopkins Medicine Institutional Review Board.

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Cite this article

Ikwuezunma, I., Beutler, G.J., Margalit, A. et al. Late spinal infections are more common after pediatric than after adult spinal deformity surgery. Spine Deform 10, 817–823 (2022). https://doi.org/10.1007/s43390-022-00494-9

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  • DOI: https://doi.org/10.1007/s43390-022-00494-9

Keywords

  • Adult spine deformity
  • Coagulase-negative staphylococci
  • Epidemiology
  • Late spinal infection
  • Pediatric orthopaedics
  • Pediatric spine deformity
  • Posterior spinal fusion
  • Propionibacterium acnes
  • Spinal instrumentation
  • Spine surgery