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The Italian Spine Youth Quality of Life questionnaire: reliability and validity of the Persian version in adolescents with spinal deformities



To assess the reliability and validity of the Persian version of the Italian Spine Youth Quality of Life (P-ISYQOL) questionnaire.


Forward/backward translations and cultural adaption processes of the ISYQOL questionnaire into Persian were conducted by an expert committee. We recruited 178 adolescents with idiopathic scoliosis (AIS) and Scheuermann’s kyphosis (SK) and 103 age-matched adolescents with no spinal deformity. Reliability was assessed by evaluating internal consistency and test–retest reliability using Cronbach’s alpha and intraclass correlation coefficient (ICC). Convergent construct validity was assessed by measuring the association between the ISYQOL and revised 22-item Scoliosis Research Society (SRS-22r) questionnaires scores. Known-groups construct validity was assessed regarding curve magnitude, deformity, age, sex, and treatment type.


Cronbach’s alpha and ICC for P-ISYQOL total score was 0.8 and 0.9, respectively. An acceptable association was observed between P-ISYQOL and SRS-22r total scores (r = − 0.5, p < 0.01). The P-ISYQOL could discriminate between adolescents with spinal deformities and adolescents with no spinal deformity as well as those with different types of deformity and treatment (p < 0.01).


The P-ISYQOL is a reliable and valid survey to assess the outcomes of adolescents with spinal deformities.

Level of evidence

Level I—diagnostic studies.

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Not applicable.

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Authors and Affiliations



TB, EE, NR, MN, MS, ZH, MJ, VM: conception or design, acquisition, analysis, or interpretation. TB, EE, NR, MN, MS, ZH, MJ, VM: draft or revision of work. TB, EE, NR, MN, MS, ZH, MJ, VM: approved the version to be published. TB, EE, NR, MN, MS, ZH, MJ, VM: agree to be accountable for all aspects of the work.

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Correspondence to Masoomeh Nakhaee.

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There is no conflict of interest about the study.

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The study protocol was approved by the research ethics committee of Kerman University of Medical Sciences (IR.KUMS.REC.1399.264). The manuscript submitted does not contain information about medical device(s)/drug(s).

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Babaee, T., Esfandiari, E., Rouhani, N. et al. The Italian Spine Youth Quality of Life questionnaire: reliability and validity of the Persian version in adolescents with spinal deformities. Spine Deform 10, 775–782 (2022).

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  • Adolescent idiopathic scoliosis
  • Scheuermann’s kyphosis
  • Reliability
  • Validity
  • Quality of life
  • Brace
  • Questionnaire