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The impact of blood conservation techniques on transfusion requirements for posterior adolescent idiopathic scoliosis corrections: do we need a routine cross-match for the operation?

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Abstract

Purpose

Various strategies are utilised to reduce blood loss and allogenic blood transfusion for posterior instrumented correction of Adolescent Idiopathic Scoliosis (AIS). The aim of this study was to evaluate post-operative blood transfusion requirements to determine whether routine cross matching of blood is essential.

Methods

This is a prospective case series of 84 patients who underwent posterior correction of AIS between September 2016 and March 2018. We reviewed demographic, operative, radiological data and transfusion requirements. Results of transfusion requirements in 44 patients who underwent Ponte osteotomies (F:M = 36:8; mean age 14.8 years) were compared with 40 patients (F:M = 9:31; mean age 14.4 years) who did not and provided the control group. A transfusion trigger of 80 mg/dl with clinical caveats was utilised. Cross matching and procurement costs of allogenic blood/unit were ascertained.

Results

Five patients required postoperative blood transfusion on days 2 or 3. Anaesthetic time (p = 0.0003) and preoperative Cobb angle (p = 0.0166) were significant variables between both groups and post-operative Hb (p = 0.0084) and number of levels fused (p = 0.0312) being significant in patients requiring transfusion. Unutilised units on the day of the operation incurred £30,030 (£380/patient or £154/unit) in operational costs.

Conclusion

Our audit demonstrates that transfusion on the day of the operation was not required. We recommend that routine crossmatching is not essential for primary posterior correction for AIS with blood conservation techniques. Blood grouping with availability of urgent blood is sufficient at the onset of operation. This has financial implications and cost savings.

Levels of evidence

III.

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References

  1. Shapiro F, Sethna N (2004) Blood loss in pediatric spine surgery. Eur Spine J 13:6–17. https://doi.org/10.1007/s00586-004-0760-y

    Article  Google Scholar 

  2. Bowen RE, Gardner S, Scaduto AA et al (2010) Efficacy of intraoperative cell salvage systems in pediatric idiopathic scoliosis patients undergoing posterior spinal fusion with segmental spinal instrumentation. Spine (Phila Pa 1976) 35:246–251. https://doi.org/10.1097/BRS.0b013e3181bdf22a

    Article  Google Scholar 

  3. Feldman JM, Roth JV, Bjoraker DG (1995) Maximum blood savings by acute normovolemic hemodilution. Anesth Analg 80:108–113. https://doi.org/10.1097/00000539-199501000-00019

    Article  CAS  PubMed  Google Scholar 

  4. Copley LAB, Richards BS, Safavi FZ et al (1999) Hemodilution as a method to reduce transfusion requirements in adolescent spine fusion surgery. Spine (Phila Pa 1976) 24:219–222. https://doi.org/10.1097/00007632-199902010-00005

    Article  CAS  Google Scholar 

  5. Carey PA, Schoenfeld AJ, Cordill RD et al (2015) A comparison of cell salvage strategies in posterior spinal fusion for adolescent idiopathic scoliosis. J Spinal Disord Tech 28:1–4. https://doi.org/10.1097/BSD.0b013e318284e0b3

    Article  PubMed  Google Scholar 

  6. Liang J, Shen J, Chua S et al (2014) Does intraoperative cell salvage system effectively decrease the need for allogeneic transfusions in scoliotic patients undergoing posterior spinal fusion? A prospective randomized study. Geochemistry Int 53:270–275. https://doi.org/10.1007/s00586-014-3282-2

    Article  Google Scholar 

  7. Jones KE, Butler EK, Barrack T et al (2017) Tranexamic acid reduced the percent of total blood volume lost during adolescent idiopathic scoliosis surgery. Int J Spine Surg 11:212–217

    Article  Google Scholar 

  8. Florentino-Pineda I, Thompson GH, Poe-Kochert C et al (2004) The effect of amicar on perioperative blood loss in idiopathic scoliosis: the results of a prospective, randomized double-blind study. Spine (Phila Pa 1976) 29:233–238. https://doi.org/10.1097/01.BRS.0000109883.18015.B9

    Article  Google Scholar 

  9. Meert KL, Kannan S, Mooney JF (2002) Predictors of red cell transfusion in children and adolescents undergoing spinal fusion surgery. Spine (Phila Pa 1976) 27:2137–2142. https://doi.org/10.1097/00007632-200210010-00012

    Article  Google Scholar 

  10. Tate DE, Friedman RJ (1992) Blood conservation in spinal surgery. Spine (Phila Pa) 17:1450–1456. https://doi.org/10.1097/00007632-199212000-00002

    Article  Google Scholar 

  11. Haynes AB, Weiser TG, Berry WR, et al (2011) WHO surgical safety checklist resources. https://www.who.int/patientsafety/safesurgery/checklist/en/

  12. Instat GraphPad (2003) Instat GraphPad version 3.00 for windows

  13. Yoshihara H, Yoneoka D (2014) National trends in spinal fusion for pediatric patients with idiopathic scoliosis: demographics, blood transfusions, and in-hospital outcomes. Spine (Phila Pa 1976) 39:1144–1150. https://doi.org/10.1097/BRS.0000000000000354

    Article  Google Scholar 

  14. Yoshihara H, Yoneoka D (2014) Predictors of allogeneic blood transfusion in spinal fusion for pediatric patients with idiopathic scoliosis in the united states, 2004–2009. Spine (Phila Pa 1976) 39:1860–1867. https://doi.org/10.1097/BRS.0000000000000530

    Article  Google Scholar 

  15. Suddock J, Crookston K (2020) Transfusion reactions. In: StatPearls [Internet]. StatPearls Publishing

  16. Youssef LA, Spitalnik SL (2017) Transfusion-related immunomodulation: a reappraisal. Curr Opin Hematol 24:551–557. https://doi.org/10.1097/MOH.0000000000000376

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Bolton-Maggs PHB (2017) Serious hazards of transfusion – conference report: celebration of 20 years of UK haemovigilance. Transfus Med 27:393–400. https://doi.org/10.1111/tme.12502

    Article  CAS  PubMed  Google Scholar 

  18. Musallam KM, Tamim HM, Richards T et al (2011) Preoperative anaemia and postoperative outcomes in non-cardiac surgery: a retrospective cohort study. Lancet 378:1396–1407. https://doi.org/10.1016/S0140-6736(11)61381-0

    Article  PubMed  Google Scholar 

  19. Lasocki S, Krauspe R, Von Heymann C et al (2015) PREPARE: The prevalence of perioperative anaemia and need for patient blood management in elective orthopaedic surgery: a multicentre, observational study. Eur J Anaesthesiol 32:160–167. https://doi.org/10.1097/EJA.0000000000000202

    Article  PubMed  Google Scholar 

  20. Hobson C, Ozrazgat-Baslanti T, Kuxhausen A et al (2015) Cost and mortality associated with postoperative acute kidney injury. Ann Surg 261:1207–1214. https://doi.org/10.1097/SLA.0000000000000732

    Article  PubMed  Google Scholar 

  21. Maldonado JR (2013) Neuropathogenesis of delirium: review of current etiologic theories and common pathways. Am J Geriatr Psychiatry 21:1190–1222. https://doi.org/10.1016/j.jagp.2013.09.005

    Article  PubMed  Google Scholar 

  22. Anand N, Idio FG, Remer S, Hoppenfeld S (1998) The effects of perioperative blood salvage and autologous blood donation on transfusion requirements in scoliosis surgery. J Spinal Disord 11:532–534. https://doi.org/10.1097/00002517-199812000-00014

    Article  CAS  PubMed  Google Scholar 

  23. Katranitsa L, Gkantsinikoudis N, Kapetanakis S et al (2018) Perioperative blood management in posterior instrumented fusion for adolescent idiopathic scoliosis: original study and short review of the literature. Folia Med (Plovdiv) 60:200–207. https://doi.org/10.1515/folmed-2017-0100

    Article  Google Scholar 

  24. Ersen O, Ekıncı S, Bılgıc S et al (2012) Posterior spinal fusion in adolescent idiopathic scoliosis with or without intraoperative cell salvage system: a retrospective comparison. Musculoskelet Surg 96:107–110. https://doi.org/10.1007/s12306-012-0203-6

    Article  PubMed  Google Scholar 

  25. Ashworth A, Klein AA (2010) Cell salvage as part of a blood conservation strategy in anaesthesia. Br J Anaesth 105:401–416. https://doi.org/10.1093/bja/aeq244

    Article  CAS  PubMed  Google Scholar 

  26. Duffy G, Tolley K (1997) Cost analysis of autologous blood transfusion, using cell salvage, compared with allogeneic blood transfusion. Transfus Med 7:189–196. https://doi.org/10.1046/j.1365-3148.1997.d01-25.x

    Article  CAS  PubMed  Google Scholar 

  27. Koerner JD, Patel A, Zhao C et al (2014) Blood loss during posterior spinal fusion for adolescent idiopathic scoliosis. Spine (Phila Pa 1976) 39:1479–1487. https://doi.org/10.1097/BRS.0000000000000439

    Article  Google Scholar 

  28. Van Popta D, Stephenson J, Patel D et al (2014) The pattern of blood loss in adolescent idiopathic scoliosis. Spine J 14:2938–2945. https://doi.org/10.1016/j.spinee.2014.05.022

    Article  PubMed  Google Scholar 

  29. Alamanda VK, Massengill DL, Rozario N et al (2018) Blood loss trends and financial implications in adolescent idiopathic scoliosis. Clin Spine Surg 31:E418–E421. https://doi.org/10.1097/BSD.0000000000000689

    Article  PubMed  Google Scholar 

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Authors and Affiliations

Authors

Contributions

SH: Original concept, discussed framework, analysed data, wrote and critically reviewed article for final acceptance. RT: Discussed framework, collected and analysed data, wrote and critically reviewed article for final acceptance. NN: Discussed framework, collected data, critically reviewed article for final acceptance. DG: Treated patients, analysed data, critically reviewed article for final acceptance. CB: Treated patients, analysed data, critically reviewed article for final acceptance. JM: Original concept, treated patients, discussed framework, analysed data, wrote and critically reviewed article for final acceptance.

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Correspondence to S. Haleem.

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The authors declare no conflict of interest in relation to this article.

IRB/Ethics statement

Local audit committee approval was obtained in the form of service evaluation (Project reference number – 19-034).

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Haleem, S., Thimmaiah, R., Nagrath, N. et al. The impact of blood conservation techniques on transfusion requirements for posterior adolescent idiopathic scoliosis corrections: do we need a routine cross-match for the operation?. Spine Deform 10, 589–593 (2022). https://doi.org/10.1007/s43390-021-00454-9

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  • DOI: https://doi.org/10.1007/s43390-021-00454-9

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