Abstract
Purpose
Various strategies are utilised to reduce blood loss and allogenic blood transfusion for posterior instrumented correction of Adolescent Idiopathic Scoliosis (AIS). The aim of this study was to evaluate post-operative blood transfusion requirements to determine whether routine cross matching of blood is essential.
Methods
This is a prospective case series of 84 patients who underwent posterior correction of AIS between September 2016 and March 2018. We reviewed demographic, operative, radiological data and transfusion requirements. Results of transfusion requirements in 44 patients who underwent Ponte osteotomies (F:M = 36:8; mean age 14.8 years) were compared with 40 patients (F:M = 9:31; mean age 14.4 years) who did not and provided the control group. A transfusion trigger of 80 mg/dl with clinical caveats was utilised. Cross matching and procurement costs of allogenic blood/unit were ascertained.
Results
Five patients required postoperative blood transfusion on days 2 or 3. Anaesthetic time (p = 0.0003) and preoperative Cobb angle (p = 0.0166) were significant variables between both groups and post-operative Hb (p = 0.0084) and number of levels fused (p = 0.0312) being significant in patients requiring transfusion. Unutilised units on the day of the operation incurred £30,030 (£380/patient or £154/unit) in operational costs.
Conclusion
Our audit demonstrates that transfusion on the day of the operation was not required. We recommend that routine crossmatching is not essential for primary posterior correction for AIS with blood conservation techniques. Blood grouping with availability of urgent blood is sufficient at the onset of operation. This has financial implications and cost savings.
Levels of evidence
III.
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Not applicable.
Code availability
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References
Shapiro F, Sethna N (2004) Blood loss in pediatric spine surgery. Eur Spine J 13:6–17. https://doi.org/10.1007/s00586-004-0760-y
Bowen RE, Gardner S, Scaduto AA et al (2010) Efficacy of intraoperative cell salvage systems in pediatric idiopathic scoliosis patients undergoing posterior spinal fusion with segmental spinal instrumentation. Spine (Phila Pa 1976) 35:246–251. https://doi.org/10.1097/BRS.0b013e3181bdf22a
Feldman JM, Roth JV, Bjoraker DG (1995) Maximum blood savings by acute normovolemic hemodilution. Anesth Analg 80:108–113. https://doi.org/10.1097/00000539-199501000-00019
Copley LAB, Richards BS, Safavi FZ et al (1999) Hemodilution as a method to reduce transfusion requirements in adolescent spine fusion surgery. Spine (Phila Pa 1976) 24:219–222. https://doi.org/10.1097/00007632-199902010-00005
Carey PA, Schoenfeld AJ, Cordill RD et al (2015) A comparison of cell salvage strategies in posterior spinal fusion for adolescent idiopathic scoliosis. J Spinal Disord Tech 28:1–4. https://doi.org/10.1097/BSD.0b013e318284e0b3
Liang J, Shen J, Chua S et al (2014) Does intraoperative cell salvage system effectively decrease the need for allogeneic transfusions in scoliotic patients undergoing posterior spinal fusion? A prospective randomized study. Geochemistry Int 53:270–275. https://doi.org/10.1007/s00586-014-3282-2
Jones KE, Butler EK, Barrack T et al (2017) Tranexamic acid reduced the percent of total blood volume lost during adolescent idiopathic scoliosis surgery. Int J Spine Surg 11:212–217
Florentino-Pineda I, Thompson GH, Poe-Kochert C et al (2004) The effect of amicar on perioperative blood loss in idiopathic scoliosis: the results of a prospective, randomized double-blind study. Spine (Phila Pa 1976) 29:233–238. https://doi.org/10.1097/01.BRS.0000109883.18015.B9
Meert KL, Kannan S, Mooney JF (2002) Predictors of red cell transfusion in children and adolescents undergoing spinal fusion surgery. Spine (Phila Pa 1976) 27:2137–2142. https://doi.org/10.1097/00007632-200210010-00012
Tate DE, Friedman RJ (1992) Blood conservation in spinal surgery. Spine (Phila Pa) 17:1450–1456. https://doi.org/10.1097/00007632-199212000-00002
Haynes AB, Weiser TG, Berry WR, et al (2011) WHO surgical safety checklist resources. https://www.who.int/patientsafety/safesurgery/checklist/en/
Instat GraphPad (2003) Instat GraphPad version 3.00 for windows
Yoshihara H, Yoneoka D (2014) National trends in spinal fusion for pediatric patients with idiopathic scoliosis: demographics, blood transfusions, and in-hospital outcomes. Spine (Phila Pa 1976) 39:1144–1150. https://doi.org/10.1097/BRS.0000000000000354
Yoshihara H, Yoneoka D (2014) Predictors of allogeneic blood transfusion in spinal fusion for pediatric patients with idiopathic scoliosis in the united states, 2004–2009. Spine (Phila Pa 1976) 39:1860–1867. https://doi.org/10.1097/BRS.0000000000000530
Suddock J, Crookston K (2020) Transfusion reactions. In: StatPearls [Internet]. StatPearls Publishing
Youssef LA, Spitalnik SL (2017) Transfusion-related immunomodulation: a reappraisal. Curr Opin Hematol 24:551–557. https://doi.org/10.1097/MOH.0000000000000376
Bolton-Maggs PHB (2017) Serious hazards of transfusion – conference report: celebration of 20 years of UK haemovigilance. Transfus Med 27:393–400. https://doi.org/10.1111/tme.12502
Musallam KM, Tamim HM, Richards T et al (2011) Preoperative anaemia and postoperative outcomes in non-cardiac surgery: a retrospective cohort study. Lancet 378:1396–1407. https://doi.org/10.1016/S0140-6736(11)61381-0
Lasocki S, Krauspe R, Von Heymann C et al (2015) PREPARE: The prevalence of perioperative anaemia and need for patient blood management in elective orthopaedic surgery: a multicentre, observational study. Eur J Anaesthesiol 32:160–167. https://doi.org/10.1097/EJA.0000000000000202
Hobson C, Ozrazgat-Baslanti T, Kuxhausen A et al (2015) Cost and mortality associated with postoperative acute kidney injury. Ann Surg 261:1207–1214. https://doi.org/10.1097/SLA.0000000000000732
Maldonado JR (2013) Neuropathogenesis of delirium: review of current etiologic theories and common pathways. Am J Geriatr Psychiatry 21:1190–1222. https://doi.org/10.1016/j.jagp.2013.09.005
Anand N, Idio FG, Remer S, Hoppenfeld S (1998) The effects of perioperative blood salvage and autologous blood donation on transfusion requirements in scoliosis surgery. J Spinal Disord 11:532–534. https://doi.org/10.1097/00002517-199812000-00014
Katranitsa L, Gkantsinikoudis N, Kapetanakis S et al (2018) Perioperative blood management in posterior instrumented fusion for adolescent idiopathic scoliosis: original study and short review of the literature. Folia Med (Plovdiv) 60:200–207. https://doi.org/10.1515/folmed-2017-0100
Ersen O, Ekıncı S, Bılgıc S et al (2012) Posterior spinal fusion in adolescent idiopathic scoliosis with or without intraoperative cell salvage system: a retrospective comparison. Musculoskelet Surg 96:107–110. https://doi.org/10.1007/s12306-012-0203-6
Ashworth A, Klein AA (2010) Cell salvage as part of a blood conservation strategy in anaesthesia. Br J Anaesth 105:401–416. https://doi.org/10.1093/bja/aeq244
Duffy G, Tolley K (1997) Cost analysis of autologous blood transfusion, using cell salvage, compared with allogeneic blood transfusion. Transfus Med 7:189–196. https://doi.org/10.1046/j.1365-3148.1997.d01-25.x
Koerner JD, Patel A, Zhao C et al (2014) Blood loss during posterior spinal fusion for adolescent idiopathic scoliosis. Spine (Phila Pa 1976) 39:1479–1487. https://doi.org/10.1097/BRS.0000000000000439
Van Popta D, Stephenson J, Patel D et al (2014) The pattern of blood loss in adolescent idiopathic scoliosis. Spine J 14:2938–2945. https://doi.org/10.1016/j.spinee.2014.05.022
Alamanda VK, Massengill DL, Rozario N et al (2018) Blood loss trends and financial implications in adolescent idiopathic scoliosis. Clin Spine Surg 31:E418–E421. https://doi.org/10.1097/BSD.0000000000000689
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SH: Original concept, discussed framework, analysed data, wrote and critically reviewed article for final acceptance. RT: Discussed framework, collected and analysed data, wrote and critically reviewed article for final acceptance. NN: Discussed framework, collected data, critically reviewed article for final acceptance. DG: Treated patients, analysed data, critically reviewed article for final acceptance. CB: Treated patients, analysed data, critically reviewed article for final acceptance. JM: Original concept, treated patients, discussed framework, analysed data, wrote and critically reviewed article for final acceptance.
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Haleem, S., Thimmaiah, R., Nagrath, N. et al. The impact of blood conservation techniques on transfusion requirements for posterior adolescent idiopathic scoliosis corrections: do we need a routine cross-match for the operation?. Spine Deform 10, 589–593 (2022). https://doi.org/10.1007/s43390-021-00454-9
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DOI: https://doi.org/10.1007/s43390-021-00454-9