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Ceramic layered double hydroxide nanohybrids for therapeutic applications

Abstract

Layered double hydroxides (LDHs) have attracted considerable interest in bio-related applications owing to their good biocompatibility, biodegradability, facile preparation, and versatile functionality such as tailored drug loading, efficient cellular delivery, targeted delivery, and the controlled release of gene, drug, or other bioactive molecules. In particular, LDHs can accommodate various therapeutic agents and have been extensively explored to achieve novel multifunctional ceramic nanohybrids for therapeutic applications. Here, we review and highlight the recent progresses in ceramic nanohybrids based on LDH materials and their related curative application systems for gene therapy, chemotherapy, phototherapy, and combination therapy. Concretely, the synthetic strategies, structural features, and functions of LDHs as nonviral vectors and their versatile hybrid systems are discussed.

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reproduced from Ref. [30]

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Acknowledgements

This work was supported by the research grant of the Chungbuk National University in 2020. This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. NRF-2019R1G1A1006582).

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Correspondence to Jae-Ha Myung, Byoung Choul Kim or Dae-Hwan Park.

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Jin, W., Ha, S., Myung, JH. et al. Ceramic layered double hydroxide nanohybrids for therapeutic applications. J. Korean Ceram. Soc. 57, 597–607 (2020). https://doi.org/10.1007/s43207-020-00090-5

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Keywords

  • Layered double hydroxide
  • Nanohybrid
  • Gene therapy
  • Chemotherapy
  • Phototherapy
  • Combination therapy