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Integrative roles of sphingosine kinase in liver pathophysiology

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Abstract

Bioactive sphingolipids and enzymes that metabolize sphingolipid-related substances have been considered as critical messengers in various signaling pathways. One such enzyme is the crucial lipid kinase, sphingosine kinase (SphK), which mediates the conversion of sphingosine to the potent signaling substance, sphingosine-1-phosphate. Several studies have demonstrated that SphK metabolism is strictly regulated to maintain the homeostatic balance of cells. Here, we summarize the role of SphK in the course of liver disease and illustrate its effects on both physiological and pathological conditions of the liver. SphK has been implicated in a variety of liver diseases, such as steatosis, liver fibrosis, hepatocellular carcinoma, and hepatic failure. This study may advance the understanding of the cellular and molecular foundations of liver disease and establish therapeutic approaches via SphK modulation.

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Acknowledgements

This research was supported by the National Research Foundation of Korea (NRF) funded by the Korean government (MOE) and the Ministry of Education [Grant no. NRF-2021R1I1A3051069 (K. M. K), and NRF-2018R1D1A1B07040460 (J. H. Y)].

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Authors and Affiliations

  1. Department of Biomedical Science, College of Natural Science, Chosun University, Gwangju, 61452, Republic of Korea

    Kyu Min Kim & Eun Jin Shin

  2. College of Korean Medicine, Dongshin University, Naju, Jeollanam-Do, 58245, Republic of Korea

    Ji Hye Yang

  3. College of Pharmacy, Chosun University, 309 Pilmun-Daero, Dong-Gu, Gwangju, 61452, Republic of Korea

    Sung Hwan Ki

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Kim, K.M., Shin, E.J., Yang, J.H. et al. Integrative roles of sphingosine kinase in liver pathophysiology. Toxicol Res. 39, 549–564 (2023). https://doi.org/10.1007/s43188-023-00193-1

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