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Toxicological Impact of Bisphenol A on Females’ Reproductive System: Review Based on Experimental and Epidemiological Studies

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Abstract

The study encompassing research papers documented in the last two decades pertaining to the possible influence of bisphenol A (BPA) on the fertility of females are appraised with emphasis on the influence of BPA in reproductive organs (uterus and ovaries) and pregnancy outcomes including discussion on the reproductive process (implantation, estrous cycle, hormone secretion); outcomes reveal a connection amongst BPA and female infertility. Ovary, uterus, and its shape as well as function can alter a person's ability to become pregnant by influencing the hypothalamus-pituitary axis in the ovarian model. Additionally, implantation and the estrous cycle may be affected by BPA. However, more research is warranted to comprehend the underlying action mechanisms and to promptly identify any imminent reproductive harm.

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Authors and Affiliations

  1. Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran

    Shahla Chaichian, Ladan Haghighi, Azam Govahi & Marziyeh Ajdary

  2. Department of Genetics and Advanced Medical Technology, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran

    Fatemeh Khodabandehloo

  3. Reproductive Sciences and Technology Research Center, Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

    Mehdi Mehdizadeh

  4. Centre of Excellence for Research in Sustainable Chemistry, Department of Chemistry Federal University of São Carlos, São Carlos, SP, 13565-905, Brazil

    Rajender S. Varma

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M.A. contributed in writing of the original draft and in conceptualization of the work. F.K., A.G., M.M. performed the collection data. S.C. and R.S.V. contributed in conceptualization, writing the review, and editing of the paper.

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Chaichian, S., Khodabandehloo, F., Haghighi, L. et al. Toxicological Impact of Bisphenol A on Females’ Reproductive System: Review Based on Experimental and Epidemiological Studies. Reprod. Sci. (2024). https://doi.org/10.1007/s43032-024-01521-y

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