Skip to main content

Advertisement

SpringerLink
Log in

The Association of ICSI Outcomes with Semen and Blood Bisphenol A Concentrations of the Male Partner

  • Male Reproduction: Original Article
  • Published:
Reproductive Sciences Aims and scope Submit manuscript

Abstract

This study investigated the association of blood and semen Bisphenol A (BPA) levels of the male partner on the reproductive outcome in intracytoplasmic sperm injection (ICSI) treatment cycles. For this prospective study (ClinicalTrials.gov identifier: NCT02703584), blood and semen samples of the male partner of the 75 women who had ICSI were analyzed. The study group consisted of men who had ICSI for male factor infertility other than azoospermia, while men with normal spermiogram whose partners underwent ICSI due to tubal factor infertility were taken as the study group. Habitual consumption of drinking water from plastic carboys/bottles (PBW) at home was also questioned in both groups as it was considered as chronic BPA exposure. The association of ICSI outcome with blood BPA (bBPA) and semen BPA (sBPA) levels was analyzed in both groups. No significant correlation was found between sperm parameters and bBPA levels in both groups. A negative correlation was found between sBPA levels and total sperm count and progressive sperm motility in men who consumed PBW. Embryo development arrest was found to be significantly higher in patients who have high sBPA levels. Although sBPA levels were not different in PBW consumers, bBPA levels were found to be significantly lower in those who consumed tap water (TW) than those who used PBW. Elevated bBPA were associated with a significant decrease in clinical pregnancy rate. Considering the widespread human exposure to BPA, the effect of BPA on the male reproductive system needs to be further examined.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

Data Availability

Not applicable.

Code Availability

Not applicable.

References

  1. Commission Regulation (EU) 2016/1179 of 19 July 2016 amending, for the purposes of its adaptation to technical and scientific progress, Regulation (EC) No 1272/2008 of the European Parliament and of the Council on classification, labelling and packaging of substances and mixtures (Text with EEA relevance). 2016.

  2. Santiago J, Silva JV, Santos MAS, Fardilha M. Fighting bisphenol A-Induced male infertility: the power of antioxidants. Antioxidants. 2021;10:289.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Presunto M, Mariana M, Lorigo M, Cairrao E. The effects of bisphenol A on human male infertility: a review of current epidemiological studies. Int J Mol Sci. 2023;24:12417.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Yadav SK, Bijalwan V, Yadav S, Sarkar K, Das S, Singh DP. Susceptibility of male reproductive system to bisphenol A, an endocrine disruptor: updates from epidemiological and experimental evidence. J Biochem Mol Toxicol. 2023;37:e23292.

    Article  CAS  PubMed  Google Scholar 

  5. Chen PP, Liu C, Zhang M, Miao Y, Cui FP, Deng YL, Luo Q, Zeng JY, Shi T, Lu TT, et al. Associations between urinary bisphenol A and its analogues and semen quality: a cross-sectional study among Chinese men from an infertility clinic. Environ Int. 2022;161:107132.

    Article  CAS  PubMed  Google Scholar 

  6. Alarcóna LM, Hauser R, Gaskins AJ. Effects of bisphenol A on male and couple reproductive health: a review. Fertil Steril. 2016;106(4):864–70.

    Article  Google Scholar 

  7. Omrana GA, Gaberb HD, Mostafac NAH, Abdel-Gaberb RM, Salahd EA. Potential hazards of bisphenol A exposure to semen quality and sperm DNA integrity among infertile men. Reprod Toxicol. 2018;81:188–95.

    Article  Google Scholar 

  8. Cariati F, D’Uonno N, Borrillo F, Iervolino S, Galdiero G, Tomaiuolo R. Bisphenol a: an emerging threat to male fertility. Reprod Biol Endocrinol. 2019;17(1):6.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Matuszczak E, Komarowska MD, Debek W, Hermanowicz A. The impact of bisphenol A on fertility, reproductive system, and development: a review of the literature. Int J Endocrinol. 2019;10:4068–717.

    Google Scholar 

  10. Vitku J, Heracek J, Sosvorova L, Hampl R, Chlupacova T, Hill M, Sobotka V, Bicikova M, Starka L. Associations of bisphenol A and polychlorinated biphenyls with spermatogenesis and steroidogenesis in two biological fluids from men attending an infertility clinic. Environ Int. 2016;89–90:166–73.

    Article  PubMed  Google Scholar 

  11. Lassen TH, Frederiksen H, Jensen TK, Petersen JH, Joensen UN, Main KM, Skakkebaek NE, Juul A, Jorgensen N, Andersson AM. Urinary bisphenol A levels in young men: association with reproductive hormones and semen quality. Environ Health Perspect. 2014;122(5):478–84.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Xu B, Chia SE, Tsakok M, Ong CN. Trace elements in blood and seminal plasma and their relationship to sperm quality. Reprod Toxicol. 1993;7(6):613–8.

    Article  CAS  PubMed  Google Scholar 

  13. Zhang X, Chang H, Wiseman S, He Y, Higley E, Jones P, Wong CK, Khedhairy A, Giesy JP, Hecker M. Bisphenol A disrupts steroidogenesis in human H295 R cells. Toxicol Sci. 2011;121(2):320–7.

    Article  CAS  PubMed  Google Scholar 

  14. Meeker JD, Calafat AM, Hauser R. Urinary bisphenol A concentrations in relation to serum thyroid and reproductive hormone levels in men from an infertility clinic. Environ Sci Technol. 2010;44(4):1458–63.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Lı Shen J, Kang Q, Mao Y, Yuan M, Le F, Yang X. Urinary bisphenol A concentration is correlated with poorer oocyte retrieval and embryo implantation outcomes in patients with tubal factor infertility undergoing in vitro fertilisation. Ecotoxicol Enviro Saf. 2020;15:187.

    Google Scholar 

  16. Goldstone AE, Chen Z, Perry MJ, Kannan K, Louis GM. Urinarybisphenol A and semenquality, theLIFE study. Reprod Toxicol. 2014;51C:7–13.

    Google Scholar 

  17. Knez J, Kranvogl R, Breznik BP, Voncina E, Vlaisavljevic V. Areurinary bisphenol A levels in men related to semen quality and embryo development after medically assisted reproduction? Fertil Steril. 2014;101(1):215–21.

    Article  CAS  PubMed  Google Scholar 

  18. Aghajani MMR, Shafi H, Tabari MG, Moslemi L, Aghamohammadi A, Hajitabar F, Mirabi P, Gorji NM. The correlation of urine bisphenol A with semen parameters in men referred to infertility centers: a cross-sectional study. Int J Fertil Steril. 2023;7(4):292–8.

    Google Scholar 

  19. Mendiola J, Jorgensen N, Andersson AM, Calafat AM, Ye X, Redmon JB, Drobnis EZ, Wang C, Sparks A, Thurston SW, et al. Are environmental levels of bisphenol a associated with reproductive function infertile men? Environ Health Perspect. 2010;118(9):1286–91.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. WHO. Laboratory manual for the examination and processing of human semen. 5th ed. Geneva: WorldHealth Organization; 2010.

    Google Scholar 

  21. Kruger TF, Acosta AA, Simmons KF, Swanson RJ, Matta JF, Oehninger S. Predictive value of abnormal sperm morphology in in vitro fertilization. Fertil Steril. 1988;49:112–7.

    Article  CAS  PubMed  Google Scholar 

  22. Anyalechi GE, Wiesenfeld HC, Kirkcaldy RD, Kissin DM, Haggerty CL, Hammond KR, Hook EW, Bernstein KT, Steinkampf MP, Geisler WM. Tubal factor infertility, in vitro fertilization, and racial disparities: a retrospective cohort in two US clinics. Sex Transm Dis. 2021;48(10):748–53.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology. The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Hum Reprod. 2011;26(6):1270–83.

  24. Souter I, Smith KW, Dimitriadis I, Ehrlich S, Williams PL, Calafat AM. The associationof bisphenol-A urinary concentrations withantral follicle counts and other measuresof ovarian reserve in women undergoing infertility treatments. Reprod Toxicol. 2013;42:224–31.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Grami D, Rtibi K, Hammami I, Selmi S, De Toni L, Foresta C, Marzouki L, Sebai H. Protective action of eruca sativa leaves aqueous extracts against bisphenol a-caused in vivo testicular damages. J Med Food. 2019;23:600–10.

    Article  PubMed  Google Scholar 

  26. Jin P, Wang X, Chang F, Bai Y, Li Y, Zhou R, Chen L. Low dose bisphenol a impairs spermatogenesis by suppressing reproductive hormone production and promoting germ cell apoptosis in adult rats. J Biomed Res. 2013;27:135–44.

    Article  CAS  PubMed  Google Scholar 

  27. Adoamneia E, Mendiola J, Vela-Soria F, Fernándezc MF, Oleac N, Jørgensene N, Swanf SH, Torres-Canteroa AM. Urinary bisphenol A concentrations are associated with reproductive parameters in young men. Environ Res. 2018;161:122–8.

    Article  Google Scholar 

  28. Chen M, Tang R, Fu G, Xu B, Zhu P, Qiao S, et al. Association of exposure to phenols and idiopathic male infertility. J Hazard Mater. 2013;250–251:115–21.

    Article  PubMed  Google Scholar 

  29. Barbonetti A, Castellini C, Di Giammarco N, Santilli G, Francavilla S, Francavilla F. In vitro exposure of human spermatozoa to bisphenol A induces pro-oxidative/apoptotic mitochondrial dysfunction. Reprod Toxicol. 2016;158:64–71.

    Google Scholar 

  30. Hulak M, Gazo I, Shaliutina A, Linhartova P. In vitro effects of BPA on the quality parameters, oxidative stress, DNA integrity and adenosine triphosphate content in sterlet (Acipenser ruthenus) spermatozoa. Comp Biochem Physiol. 2013;158:64–71.

    CAS  Google Scholar 

  31. Völkel W, Bittner N, Dekant W. Quantitation of bisphenol A and bisphenol A glucuronide in biological samples by high performance liquid chromatography-tandem mass spectrometry. Drug Metab Dispos. 2005;33:1748–57.

    Article  PubMed  Google Scholar 

  32. Radwan P, Wielgomas B, Radwan M, Krasiński R, Klimowska A, Kaleta D, Jurewicz J. Urinary bisphenol A concentrations and in vitro fertilization outcomes among women from a fertility clinic. Reprod Toxicol. 2020;96:216–20.

    Article  CAS  PubMed  Google Scholar 

  33. Yenigül NN, Dilbaz S, Dilbaz B, Kaplanoğlu İ, Güçel F, Aldemir O, Baser E, Ozelci R, Tekin OM. The effect of PBW consumption on outcomes of ICSI cycles undertaken for unexplained infertility. Reprod Biomed Online. 2021;43(1):91–9.

    Article  PubMed  Google Scholar 

Download references

Funding

This work was supported by the University of Health Sciences within the scope of the scientific research project, and financial support for ELISA kits was obtained from the university “Scientific Research Projects” fund.

Author information

Authors and Affiliations

  1. IVF Clinic of the University of Heath Sciences School of Medicine, Ankara Etlik Zübeyde Hanım Women’s Health Training and Research Hospital, Ankara, Turkey

    Runa Ozelci, Serdar Dilbaz, Berna Dilbaz, Oya Aldemir, İskender Kaplanoğlu & Funda Güçel

  2. Department of Obstetrics and Gynecology, University of Health Sciences School of Medicine, Bursa Yüksek Ihtisas Research and Training Hospital, Bursa, Turkey

    Nefise Nazlı Yenigül

  3. İzmir Can Hospital, Izmir, Turkey

    Emre Başer

  4. University of Health Sciences School of Medicine, Ankara City Hospital, Ankara, Turkey

    Özlem Moraloğlu Tekin

Authors
  1. Runa Ozelci
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nefise Nazlı Yenigül
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Serdar Dilbaz
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Berna Dilbaz
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Oya Aldemir
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. İskender Kaplanoğlu
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Funda Güçel
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Emre Başer
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Özlem Moraloğlu Tekin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Runa Ozelci.

Ethics declarations

Ethical Approval

This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Health Science University Etlik Zübeyde Hanim Women’s Health Education and Research Hospital Clinical Research Ethics Committee (Date:22.05.2019/ No:2019/21).

Informed Consent

Informed consent was obtained from the participants included in this study.

Consent for Publication

Not applicable.

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ozelci, R., Yenigül, N.N., Dilbaz, S. et al. The Association of ICSI Outcomes with Semen and Blood Bisphenol A Concentrations of the Male Partner. Reprod. Sci. (2024). https://doi.org/10.1007/s43032-023-01446-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s43032-023-01446-y

Keywords

Search

Navigation