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Alteration in Effects of Endometriosis on Fecundity According to Pregnancy Experience in Mouse Model

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Abstract

This study is aimed at identifying variations in the effect of endometriosis on fecundity in a mouse model based on prior pregnancy experience. Endometriosis is one of the most prevalent gynecological diseases and is known to impact female fecundity adversely. In this study, an endometriosis mouse model was established by allografting uterine horn tissue using Pelch’s method. The effect of endometriosis on fecundity was confirmed in primiparous and multiparous female mice. As fecundity indicators, the pregnancy rate, number of litters, pregnancy period, and survival rate of the pups were investigated. As a result of the experiment, the pregnancy rate decreased, and the pregnancy period tended to be shorter in primiparous female mice. However, there was no significant change in the multiparous mice. In addition, it has been established that correlations exist between the size of lesions and certain fecundity indicators of the lesion, even among primiparous and multiparous females with endometriosis. The study attempted to demonstrate a link between pregnancy experience and fecundity changes caused by endometriosis by experimentally reproducing clinical results using mouse models. These results suggest strategies for identifying several pathophysiological characteristics of endometriosis.

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Funding

This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI22C1424). And this work was supported by Commercializations Promotion Agency for R&D Outcomes grant funded by the Korea government (the Ministry of Science and ICT) (Project No. 1711177795).

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Author notes

  1. Wonhyoung Park and Miji Kim contributed equally to this work.

Authors and Affiliations

  1. Institute of Animal Molecular Biotechnology and Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea

    Wonhyoung Park, Miji Kim & Gwonhwa Song

  2. Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, 03080, Republic of Korea

    Hee Seung Kim & Soo Jin Park

  3. Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea

    Hee Seung Kim

  4. Department of Biological Sciences, College of Science, Sungkyunkwan University, Suwon, 16419, Republic of Korea

    Whasun Lim

  5. Department of Plant & Biomaterials Science, Gyeongsang National University, Jinju, 52725, Republic of Korea

    Sunwoo Park

  6. Department of GreenBio Science, Gyeongsang National University, Jinju, 52725, Republic of Korea

    Sunwoo Park

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  1. Wonhyoung Park
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Contributions

SJP, WL, and SP designed the study. WP and MK conducted experiments and analyzed the data, and HK and GS interpreted the data. WL and SP provided reagents. WP and MK wrote the original draft of the manuscript, and SJP, WL, and SP reviewed the draft of the manuscript. All authors have read and approved the manuscript.

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Correspondence to Soo Jin Park, Whasun Lim or Sunwoo Park.

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Park, W., Kim, M., Kim, H.S. et al. Alteration in Effects of Endometriosis on Fecundity According to Pregnancy Experience in Mouse Model. Reprod. Sci. 31, 404–412 (2024). https://doi.org/10.1007/s43032-023-01426-2

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  • DOI: https://doi.org/10.1007/s43032-023-01426-2

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