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Are Vascular Endothelium and Angiogenesis Effective MicroRNA Biomarkers Associated with the Prediction of Early-Onset Preeclampsia (EOPE) and Adverse Perinatal Outcomes?

  • Maternal Fetal Medicine/Biology: Original Article
  • Published:
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Abstract

MicroRNA is associated with angiogenesis, invasion, proliferation, and vascular endothelial remodeling of various diseases. We aimed to investigate serum MicroRNA (miRNA) levels in preeclampsia (PE) and to determine whether any changes in miRNA levels are useful in predicting early onset preeclampsia (EOPE) and adverse perinatal outcomes. A total of 89 pregnant patients were enrolled in this prospective case–control study (55 PE and 34 healthy controls). miR-17, miR-20a, miR-20b, miR126, miR155, miR-200, miR-222, and miR-210 levels were studied in maternal serum in preeclamptic pregnant women. Multiple logistic regression analyses analyzed the risk factors which are associated with EOPE and adverse maternal outcomes. The Real-time RT-PCR method was used to determine maternal serum miRNA levels. Serum miR-17, miR-20a, miR-20b, miR126, and miR-210 levels were significantly higher in PE than the control group (p < .001, p < .001, p < .001, p < .001 and p = .047 respectively). Increased miR-17, miR-20a, and miR-20b levels were independently associated with PE (OR: 0.642, 95%Cl: 0.486–0.846, p = .002; OR: 0.899, 95%Cl: 0.811–0.996, p = .042 and OR: 0.817, 95%Cl: 0.689–0.970, p = .021). Increased miR-17 and miR-126 levels were negatively correlated with serum EOPE in PE (r = -.313, p = .020), and increased miR-210 levels were significantly positively correlated with EOPE in PE (r = .285, p = .005). Increased expression of serum miR-17, miR-20a, miR-20b, miR126, and miR-210 were found to be associated with PE, also increased expression of miR-17, miR-20a, and miR-20b were to be predicted with PE, also increased maternal serum miR-17 and miR-126 expressions were negatively correlated and increased miR-210 expression was positively correlated with EOPE in PE women.

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Acknowledgements

The authors are thankful to the Selcuk University in Turkey for funding under the network scheme of the Project. (Ref no.2020/94).

Funding

This study was financially supported by Selcuk University.

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Authors and Affiliations

  1. Department of Perinatology, KTO Karatay University Faculty of Medicine, Konya, Turkey

    Sibel Ozler

  2. Obstetrics and Gynecology, Selcuk University Faculty of Medicine, Konya, Turkey

    Aysegul Kebapcilar & Cetin Celik

  3. Medical Genetics, Selcuk University Faculty of Medicine, Konya, Turkey

    Ebru Marzioglu Ozdemir

  4. Obstetrics and Gynecology, Health Ministry Of Turkish Republic, Dr. Ali Kemal Belviranlı Obstetrıcs And Gynecology Hospıtal, Konya, Turkey

    Muhammed Mert

  5. Konya City Hospital, Konya, Turkey

    Mehmet Nurullah Arıkan

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  1. Sibel Ozler
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  2. Aysegul Kebapcilar
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Contributions

SO and AK conceived the idea; SO, MM, and MNA collected the data; EMO provided intellectual inputs; SO, AK, EMO, MM, and CC wrote.

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Correspondence to Sibel Ozler.

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Ethics Approval

The study was approved by the Clinical Research Ethics Committee of Selcuk University in Turkey (approval date/ number: 19.02.2020/04).

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Informed consent was obtained from all patients for being included in the study.

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Ozler, S., Kebapcilar, A., Ozdemir, E.M. et al. Are Vascular Endothelium and Angiogenesis Effective MicroRNA Biomarkers Associated with the Prediction of Early-Onset Preeclampsia (EOPE) and Adverse Perinatal Outcomes?. Reprod. Sci. 31, 803–810 (2024). https://doi.org/10.1007/s43032-023-01367-w

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  • DOI: https://doi.org/10.1007/s43032-023-01367-w

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