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N6‐methyladenosine (m6A) Modification in Preeclampsia

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Abstract

Recently, epitranscriptional modification of N6-methyladenosine (m6A) has received growing attention in the research on the pathogenesis of preeclampsia. Advances in m6A sequencing have revealed the molecular mechanism and importance of m6A modification. In addition, epitranscriptional modification of m6A is closely related to the metabolic processes of placental tissues and cells in preeclampsia. This article reviews the composition, mode of action, and bioinformatics analysis of m6A modification-related proteins, and their biological function in the progression of preeclampsia. The relationship between m6A modification and preeclampsia risk factors, such as diabetes, cardiovascular disease, obesity, and psychological stress, is summarized to provide new ideas for studying PE-targeting molecules.

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  1. Department of Obstetrics and Gynecology, First Affiliated Hospital of Nanjing Medical University, Jiangsu Province, Nanjing, 210029, People’s Republic of China

    Tingting Zhang, Ziyan Jiang, Nana Yang, Zhiping Ge, Qing Zuo, Shiyun Huang & Lizhou Sun

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  1. Tingting Zhang
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Zhang, T., Jiang, Z., Yang, N. et al. N6‐methyladenosine (m6A) Modification in Preeclampsia. Reprod. Sci. 30, 3144–3152 (2023). https://doi.org/10.1007/s43032-023-01250-8

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