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The Effect of the Allelics of Ser680Asn Polymorphisms of Follicle-Stimulating Hormone Receptor Gene in IVF/ICSI Cycles: a Systematic Review and Meta-analysis

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Abstract

A significant number of single-nucleotide polymorphisms (SNPs) of the follicle-stimulating hormone receptor (FSHr) can modify the response to exogenous FSH administration. A significant diversity in response to controlled ovarian stimulation (COS) in assisted reproductive technologies (ART) according to the type of allelic has been reported. We aimed to evaluate the relation between the Asn680Ser allelics and COS. A total of 4 electronic databases were searched for articles published up to August 2021. Prospective and retrospective comparative studies which reported outcomes after COS in patients who underwent genotyping for the detection of FSHr polymorphisms were considered eligible. A total of 11 studies including 4343 patients with Asn680Ser polymorphisms of the FSHr were included. Patients carrying the Asn/Asn allelic provide elevated E2 on the day of human chorionic gonadotropin (hCG) administration (1549 patients MD 262.39 pg/ml, p = 0.0007), but less transferrable embryos as compared with Ser/Ser genotype (283 patients MD − 0.11 embryos, p = 0.04). Ans/Ser versus Ser/Ser genotypes showed a higher E2 on the day of hCG administration (1799 patients, MD 207.86 pg/ml, p = 0.02). Pregnancy rates were similar in all combination of genotypes. There is currently no strong evidence suggesting that the examination of one gene in relation to genotypes can be effectively used as single tool to improve COS. However, polygenic analysis of different polymorphisms by analyzing the genetic profile of each individual could be useful. Further research is warranted to develop an algorithm that will enable simultaneous analysis of many genes, which combined with hormonal profile could promote treatment individualization.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens School of Medicine, Athens, Greece

    Anastasia Prodromidou, Depy Mavrogianni, Nikolaos Kathopoulis & Kalliopi I. Pappa

  2. Department of Microbiology, Medical School, Biopathology University of Athens, Athens, Greece

    Evangelia Dimitroulia

  3. Athens Medical School, Kapodistrian University of Athens, Fertility Institute, Athens, Greece

    Dimitrios Loutradis

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  1. Anastasia Prodromidou
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  2. Evangelia Dimitroulia
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  3. Depy Mavrogianni
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  4. Nikolaos Kathopoulis
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  5. Kalliopi I. Pappa
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  6. Dimitrios Loutradis
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Contributions

A Prodromidou: project development, data collection, data analysis, data curation, investigation, methodology, writing original draft. E Dimitroulia: data curation, data collection, investigation, methodology, writing original draft. D Mavrogianni: data collection, manuscript writing. N Kathopoulis: data analysis, writing original draft. K Pappa: data analysis, visualization, writing, review and editing of original draft. D Loutradis: project development, data analysis, study design, quality control of data and algorithms, data interpretation, validation, visualization, writing, review and editing of original draft. All authors reviewed and approved the final draft of the manuscript.

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Correspondence to Anastasia Prodromidou.

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Prodromidou, A., Dimitroulia, E., Mavrogianni, D. et al. The Effect of the Allelics of Ser680Asn Polymorphisms of Follicle-Stimulating Hormone Receptor Gene in IVF/ICSI Cycles: a Systematic Review and Meta-analysis. Reprod. Sci. 30, 428–441 (2023). https://doi.org/10.1007/s43032-022-00996-x

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