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Placenta Accreta has a Low Association with Hypertensive Disease During Pregnancy: A Systematic Review Incorporating a Network Meta-analysis

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Abstracts

A meta-analysis was performed to evaluate the potential relationship between hypertensive disease during pregnancy and placenta accreta. A systematic literature search in OVID, Embase, Cochrane Library, PubMed, and Google scholar up to May 2021 was done, and 4 studies were found including 47,353 pregnant women at the start of the study; 4283 of them had hypertensive disease during pregnancy and 493 had placenta accreta. They were reporting relationships between hypertensive disease during pregnancy and placenta accreta. The odds ratio (OR) with 95% confidence intervals (CIs) was calculated to assess the potential relationship between hypertensive disease during pregnancy and placenta accreta using the dichotomous with a random or fixed-effect model. Hypertensive disease during pregnancy was significantly related to lower prevalence of placenta accreta (OR, 0.60; 95% CI, .38-.94, p = 0.03) compared with control (no hypertensive disease during pregnancy). When looking at the result comparing the prevalence of hypertensive disease during pregnancy in women with placenta accreta compared with control (no placenta accreta), we found that the placenta accreta was significantly related to lower prevalence of hypertensive disease during pregnancy (OR, 0.59; 95% CI, 0.38–0.94, p = 0.03) compared with control. Hypertensive disease during pregnancy may have a lower prevalence of placenta accreta. Further studies are required to validate these findings.

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Data Availability

The datasets analyzed during the current study are available from the corresponding author on reasonable request.

Abbreviations

OR:

Odds ratio

CIs:

Confidence intervals

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Acknowledgements

We appreciate the help of Miss Nada Mohamed A Elkamel for her help in improving the quality of our figures.

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Authors and Affiliations

  1. Intensive Care Unit, Huzhou Maternity & Child Health Care Hospital, Huzhou, 313000, Zhejiang Province, China

    Lingli Li, Luping Liu & YuYue Xu

Authors
  1. Lingli Li
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  2. Luping Liu
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  3. YuYue Xu
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Contributions

(1) Conception and design: Lingli Li.

(2) Administrative support: All authors.

(3) Provision of study materials or subjects: All authors.

(4) Collection and assembly of data: Luping Liu, YuYue Xu.

(5) Data analysis and interpretation: All authors.

(6) Manuscript writing: All authors.

(7) Final approval of manuscript: All authors.

All authors have read and approved the manuscript.

Corresponding author

Correspondence to Lingli Li.

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The authors declare that they have no competing interests.

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Li, L., Liu, L. & Xu, Y. Placenta Accreta has a Low Association with Hypertensive Disease During Pregnancy: A Systematic Review Incorporating a Network Meta-analysis. Reprod. Sci. 29, 2119–2126 (2022). https://doi.org/10.1007/s43032-022-00938-7

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  • DOI: https://doi.org/10.1007/s43032-022-00938-7

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