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A Comparison of Prostaglandin Profile in Human Follicular Fluid Between White and Black/Hispanic Women

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Abstract

The aim of the study is to compare prostaglandin (PG) profiles in human follicular fluid between White and Black/Hispanic women using data from a previously published study. A retrospective cohort study of 5 White and 5 Black/Hispanic women who underwent oocyte retrieval was conducted. Human follicular fluid was obtained from the first follicle entered at time of oocyte retrieval for patients undergoing in vitro fertilization cycles (IVF). PG levels were compared using mass spectroscopy with known standards to quantify PG levels. Five White women were matched with 5 Black/Hispanic women with diagnosis. Both cohorts had similar levels of age, body mass index, and IVF cycle characteristics. There were no statistical differences in PG profiles (PGE2, PGF1α, PGF2α, or 8 iso-PGF1α). In this small repeat analysis of previously studied data, there were no differences noted in PG profiles in follicular fluid. Larger studies are needed to verify this finding. This study further demonstrates the lack of representation of minority patients in studies.

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Data Availability

The raw data used to support the findings of this study are available from the corresponding author upon request.

Code Availability

N/A.

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Authors and Affiliations

  1. Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Madigan Army Medical Center, 9040 Jackson Ave, Tacoma, WA, 98431, USA

    Anne Roshong & Bruce Pier

Authors
  1. Anne Roshong
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  2. Bruce Pier
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Corresponding author

Correspondence to Bruce Pier.

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Ethics Approval

IRB approval previously obtained, copy of approval attached.

Consent to Participate

Patients were appropriately consented for inclusion in this study.

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N/A.

Conflict of Interest

The authors declare no competing interests.

Disclaimer

The views expressed in this abstract/manuscript are those of the authors and do not reflect the official policy or position of the Department of the Army, Department of Defense, or the US Government.

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Roshong, A., Pier, B. A Comparison of Prostaglandin Profile in Human Follicular Fluid Between White and Black/Hispanic Women. Reprod. Sci. 29, 2039–2042 (2022). https://doi.org/10.1007/s43032-022-00893-3

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  • DOI: https://doi.org/10.1007/s43032-022-00893-3

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