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Anti-inflammatory and Antioxidant Effects of Pyrroloquinoline Quinone in L-NAME-Induced Preeclampsia-Like Rat Model

Abstract

Preeclampsia (PE) is a pregnancy complication commonly characterized by high blood pressure. Although it is generally believed that the placenta is the root cause of PE, the exact pathogenesis is unknown; consequently, there is no standard clinical treatment. Therefore, it is necessary to explore new therapeutic drugs. Several studies have reported that pyrroloquinoline quinone (PQQ) exhibits anti-inflammatory and antioxidative effects. The purpose of this study was to investigate the protective effect of PQQ diet supplementation on PE-like rat models. L-NAME induced PE-like model rats were intraperitonially administrated with PQQ. The results showed that PQQ significantly improved clinical manifestations and pregnancy outcomes of PE-like rats. The levels of related inflammatory and antioxidant markers were also significantly reversed. A mechanism study showed that PQQ may achieve the above therapeutic effects by inhibiting NF-κB and promoting Nrf2 antioxidant pathways. In conclusion, we showed the protective effect of PQQ on PE-like model rats, by improving anti-inflammation and antioxidation effect through the NF-κB-Nrf2 pathway.

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All data generated or analyzed during this study were included in this article.

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Acknowledgements

We thank all of the project participants for their contributions.

Funding

This study was supported by the Changzhou Municipal Health Commission (CJ20200096).

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Authors

Contributions

Huihui Wang and Xuting Shi contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Xuting Shi. The first draft of the manuscript was written by Xuting Shi and Minhui Li and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Xuting Shi.

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Ethics Approval

Animal tests conducted in this study were approved by the Ethics Committee of Jiangsu Keygentec biotechnology experimental animal center (IACUC-001–19).

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Not applicable.

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Conflict of Interest

The authors declare that they have no conflict of interest.

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Cite this article

Wang, H., Li, M., Chen, P. et al. Anti-inflammatory and Antioxidant Effects of Pyrroloquinoline Quinone in L-NAME-Induced Preeclampsia-Like Rat Model. Reprod. Sci. (2021). https://doi.org/10.1007/s43032-021-00743-8

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Keywords

  • Pyrroloquinoline quinone
  • Preeclampsia
  • L-NAME
  • Placenta
  • Antioxidation