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Intrahepatic Cholestasis of Pregnancy: Toward Improving Perinatal Outcome

Abstract

Intrahepatic cholestasis of pregnancy (ICP) is associated with poor perinatal outcomes in some women such as preterm delivery and fetal demise. Ursodeoxycholic acid (UDCA) is the main therapeutic agent for ICP, but recent evidence failed to show an impact on most perinatal outcomes. Our objective is to summarize the latest evidence in the management of ICP, with a focus on perinatal outcome. We propose a practical approach that combines pharmacotherapy with biochemical and fetal testing, as well as delivery planning.

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Correspondence to Antonio F. Saad.

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Ursodeoxycholic acid improves some perinatal outcomes. We propose an updated practical approach to ICP combining pharmacotherapy with biochemical and fetal testing, as well as delivery planning.

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Saad, A.F., Pacheco, L.D., Chappell, L. et al. Intrahepatic Cholestasis of Pregnancy: Toward Improving Perinatal Outcome. Reprod. Sci. (2021). https://doi.org/10.1007/s43032-021-00740-x

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Keywords

  • Cholestasis
  • Pregnancy
  • Bile acid
  • Hepatic disease