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Effects of Resveratrol on Receptor Expression and Serum Levels of Estrogen and Progesterone in the Rat Endometritis Model

  • Endometrium: Original Article
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Abstract

Endometritis is characterized by inflammation of the endometrial lining that leads to reduced reproductive potential. Restoring the impaired hormonal balance is an important component of endometritis treatment. The purpose of the current study was to evaluate the effects of resveratrol on estrogen and progesterone hormone status in endometritis. Mature female Sprague Dawley rats were used, and endometritis was induced by intrauterine infusion of Escherichia coli. Animals were treated with resveratrol alone or combined with marbofloxacin. Compared to the non-treated endometritis group, resveratrol treatment reduced serum oestradiol levels, increased serum progesterone levels, enhanced estrogen receptor (ER) expression in the uterine stroma, decreased ESR1 gene expression, and raised ESR2 gene expression. Resveratrol administration combined with marbofloxacin also increased ER expression in the uterine gland and progesterone receptor expression in the uterine epithelium. The findings of this study suggest that the actions of resveratrol on progesterone levels and estrogen receptor expression might be responsible for its beneficial effect in rats with endometritis.

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Funding

This study was supported by research grant from the Scientific and Technical Research Council of Turkey (TUBITAK) (Grant number 215S660).

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Authors and Affiliations

  1. Department of Pharmacology, Faculty of Pharmacy, Gazi University, Etiler, 06330, Ankara, Turkey

    Sevtap Han & Mecit Orhan Uludag

  2. Department of Pathology, Gülhane Research and Education Hospital, Etlik, 06010, Ankara, Turkey

    Ali Fuat Cicek

  3. Department of Obstetrics and Gynecology, Zekai Tahir Burak Women’s Health Research and Education Hospital, Altindag, 06230, Ankara, Turkey

    Aytekin Tokmak & Nilufer Ercan Gokay

  4. Department of Microbiology, Faculty of Veterinary, Ankara University, Dışkapı, 06110, Ankara, Turkey

    Tugce Yildirir Ustun

  5. Laboratory Animal Care and Research Unit, Department of Pharmacology, Faculty of Pharmacy, Gazi University, Etiler, 06330, Ankara, Turkey

    Murside Ayse Demirel

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  1. Sevtap Han
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  2. Ali Fuat Cicek
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Contributions

S Han: project/protocol development, data collection and analysis, and manuscript writing/editing

AF Cicek: protocol development, data collection, and manuscript writing

A Tokmak: protocol development and data collection

T Yildirir Ustun: protocol development and data collection

N Ercan Gokay: data collection

MO Uludag: data analysis

MA Demirel: project/protocol development, data collection and analysis, and manuscript writing/editing

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Correspondence to Sevtap Han.

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All animals were maintained in accordance with the directions of Guide for the Care and Use of Laboratory Animals. The experimental procedure was approved by the Experimental Animal Ethics Committee of Gazi University (G.U.ET- 15.037).

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Han, S., Cicek, A.F., Tokmak, A. et al. Effects of Resveratrol on Receptor Expression and Serum Levels of Estrogen and Progesterone in the Rat Endometritis Model. Reprod. Sci. 28, 2610–2622 (2021). https://doi.org/10.1007/s43032-021-00586-3

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