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Effects of PGT-A on Pregnancy Outcomes for Young Women Having One Previous Miscarriage with Genetically Abnormal Products of Conception

  • Reproductive Genetics: Original Article
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Abstract

In this retrospective study, the effect of preimplantation genetic testing for aneuploidy (PGT-A) was evaluated in women younger than 38 years with a history of one prior miscarriage and embryonic chromosomal abnormalities were detected in previous products of conception (POCs). Abnormal karyotypes were detected in POCs at our center between January 2014 and December 2017. Of the women included in this analysis, 124 continued with conventional in vitro fertilization/intracytoplasmic sperm injection cycles (non-PGT-A group) and 93 chose PGT-A cycles (PGT-A group), and the pregnancy outcomes in both groups were compared. Although the clinical pregnancy rate per embryo transfer was significantly higher in the PGT-A group (67.23% vs. 51.85%, p-adj = 0.01), no between-group differences were found in the live birth rate or miscarriage rate (45.38% vs. 40.74%, p-adj = 0.59; 16.25% vs. 14.29%, p-adj = 0.15). Women in both groups had comparative cumulative live birth rates (PGT-A vs. non-PGT-A, 58.06% vs. 53.23%, p = 0.48). The main results of this study suggest that PGT-A is not associated with an increased likelihood of a live birth or a decreased rate of miscarriage among women younger than 38 years without recurrent pregnancy loss and with a history of POCs with embryonic chromosomal abnormalities.

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Acknowledgments

We thank Yan Li, Tianxiang Ni, and Caiyi Huang for their suggestions regarding this article. Special thanks are given to Jingfu Yang for assisting with clinical data collection.

Funding

This work was supported by the National Key Research and Development Program of China (2016YFC1000202, 2018YFC1002804).

Author information

Authors and Affiliations

  1. Center for Reproductive Medicine, Shandong University, 157 Jingliu Road, Jinan, 250012, Shandong, China

    Tingting Zhou, Yueting Zhu, Hongchang Li, Wenjie Jiang, Qian Zhang, Juanjuan Lu, Junhao Yan & Zi-Jiang Chen

  2. National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, 250012, Shandong, China

    Tingting Zhou, Yueting Zhu, Hongchang Li, Wenjie Jiang, Qian Zhang, Juanjuan Lu, Junhao Yan & Zi-Jiang Chen

  3. Key laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, 250012, Shandong, China

    Tingting Zhou, Yueting Zhu, Hongchang Li, Wenjie Jiang, Qian Zhang, Juanjuan Lu, Junhao Yan & Zi-Jiang Chen

  4. Shandong Provincial Clinical Medicine Research Center for Reproductive Health, Shandong University, Jinan, 250012, Shandong, China

    Tingting Zhou, Yueting Zhu, Hongchang Li, Wenjie Jiang, Qian Zhang, Juanjuan Lu, Junhao Yan & Zi-Jiang Chen

  5. Department of OB/GYN, Weihai Municipal Hospital, Binzhou Medical University, Weihai, 264200, Shandong, China

    Juan Zhang

  6. Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, China

    Zi-Jiang Chen

  7. Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

    Zi-Jiang Chen

Authors
  1. Tingting Zhou
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  2. Yueting Zhu
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  3. Juan Zhang
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  6. Qian Zhang
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  7. Juanjuan Lu
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  8. Junhao Yan
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  9. Zi-Jiang Chen
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Contributions

T.Z. and Y.Z. conceived of the study under the supervision of J.Y. and Z-J.C. T.Z. designed the study and wrote the initial manuscript. J.Z. collected the villus tissue from miscarriage samples. Y.Z. and H.L. acquired the patients’ data. W.J. conducted the genetic analyses. Q.Z. and J.L. revised the manuscript. T.Z., Y.Z., and J.Z. contributed equally to this manuscript as first authors.

Corresponding author

Correspondence to Junhao Yan.

Ethics declarations

Research Ethics

This study protocol was approved by the Institutional Review Board (Center for Reproductive Medicine, Shandong University) on December 12, 2019.

Patient Consent

All patients provided informed consent to participate in the study before their POC samples were collected.

Conflicts of interest

None

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Tingting Zhou, Yueting Zhu and Juan Zhang should be regarded as joint first authors.

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Zhou, T., Zhu, Y., Zhang, J. et al. Effects of PGT-A on Pregnancy Outcomes for Young Women Having One Previous Miscarriage with Genetically Abnormal Products of Conception. Reprod. Sci. 28, 3265–3271 (2021). https://doi.org/10.1007/s43032-021-00542-1

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  • DOI: https://doi.org/10.1007/s43032-021-00542-1

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