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Letter to the Editor: Fletcher NM, Harper AK, Memaj I, Fan R, Morris RT, Saed GM. Molecular Basis Supporting the Association of Talcum Powder Use with Increased Risk of Ovarian Cancer. Reprod Sci. 2019;26(12):1603–12. DOI: 10.1177/1933719119831773

Reproductive Sciences volume 27, pages 1834–1835 (2020)Cite this article

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References

  1. Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB. Oxidative stress, inflammation, and cancer: how are they linked? Free Radic Biol Med. 2010;49(11):1603–16.

    Article  CAS  Google Scholar 

  2. Zazenski R, Ashton WH, Briggs D, Chudkowski M, Kelse JW, MacEachern L, et al. Talc: occurrence, characterization, and consumer applications. Regul Toxicol Pharmacol. 1995;21(2):218–29.

    Article  CAS  Google Scholar 

  3. Quinlan TR, BeruBe KA, Hacker MP, Taatjes DJ, Timblin CR, Goldberg J, et al. Mechanisms of asbestos-induced nitric oxide production by rat alveolar macrophages in inhalation and in vitro models. Free Radic Biol Med. 1998;24(5):778–88.

    Article  CAS  Google Scholar 

  4. Hillegass JM, Shukla A, Lathrop SA, MacPherson MB, Fukagawa NK, Mossman BT. Assessing nanotoxicity in cells in vitro. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2010;2(3):219–31.

    Article  CAS  Google Scholar 

  5. Endo-Capron S, Renier A, Janson X, Kheuang L, Jaurand MC. In vitro response of rat pleural mesothelial cells to talc samples in genotoxicity assays (sister chromatid exchanges and DNA repair). Toxicol in Vitro. 1993;7(1):7–14.

    Article  CAS  Google Scholar 

  6. Endo-Capron S, Fleury-Feith J, Nebut M, De Neef R, Jaurand M. Some in vivo and in vitro studies carried out with talc samples. In: Health Related Effects of Phyllosilicates. Springer; 1990. p. 369–75.

    Google Scholar 

  7. US Environmental Protection Agency (EPA). Health Assessment Document for Talc. Washington: Environmental Criteria and Assessment Office, Office of Research and Development; 1992.

    Google Scholar 

  8. Mossman BT, Lippmann M, Hesterberg TW, Kelsey KT, Barchowsky A, Bonner JC. Pulmonary endpoints (lung carcinomas and asbestosis) following inhalation exposure to asbestos. J Toxicol Environ Health B Crit Rev. 2011;14(1–4):76–121.

    Article  CAS  Google Scholar 

  9. Anderson EL, Sheehan PJ, Kalmes RM, Griffin JR. Assessment of health risk from historical use of cosmetic talcum powder. Risk Anal. 2017;37(5):918–29.

    Article  Google Scholar 

  10. Barlow CA, Marsh GM, Benson S, Finley BL. The mineralogy and epidemiology of cosmetic talc. Toxicol Appl Pharmacol. 2018;361:173.

    Article  CAS  Google Scholar 

  11. Boffetta P, Mundt KA, Thompson WJ. The epidemiologic evidence for elongate mineral particle (EMP)-related human cancer risk. Toxicol Appl Pharmacol. 2018;361:100–6.

    Article  CAS  Google Scholar 

  12. Garabrant DH, Pastula ST. A comparison of asbestos fiber potency and elongate mineral particle (EMP) potency for mesothelioma in humans. Toxicol Appl Pharmacol. 2018;361:127–36.

    Article  CAS  Google Scholar 

  13. Pira E, Coggiola M, Ciocan C, Romano C, La Vecchia C, Pelucchi C, et al. Mortality of talc miners and millers from Val Chisone, Northern Italy: an updated cohort study. J Occup Environ Med. 2017;59(7):659–64.

    Article  Google Scholar 

  14. Price B. Industrial-grade talc exposure and the risk of mesothelioma. Crit Rev Toxicol. 2010;40(6):513–30.

    Article  CAS  Google Scholar 

  15. Wergeland E, Gjertsen F, Vos L, Grimsrud TK. Cause-specific mortality and cancer morbidity in 390 male workers exposed to high purity talc, a six-decade follow-up. Am J Ind Med. 2017;60(9):821–30.

    Article  Google Scholar 

  16. Smith WE, Hubert DD, Sobel HJ, Marquet E. Biologic tests of tremolite in hamsters. Dusts and Disease: Proceedings of the Conference on Occupational Exposures to Fibrous and Particulate Dusts and Their Extension into the Environment Park Forest South, IL: Pathotox Publishers Inc.; 1979.

  17. Stanton MF, Layard M, Tegeris A, Miller E, May M, Morgan E, et al. Relation of particle dimension to carcinogenicity in amphibole asbestoses and other fibrous minerals. J Natl Cancer Inst. 1981;67(5):965–75.

    CAS  PubMed  Google Scholar 

  18. Stenback F, Rowlands J. Role of talc and benzo(a)pyrene in respiratory tumor formation. An experimental study. Scand J Respir Dis. 1978;59(3):130–40.

    CAS  PubMed  Google Scholar 

  19. Wagner JC, Berry G, Cooke TJ, Hill RJ, Pooley FD, Skidmore JW. Animal experiments with talc. Inhaled Part. 1975;4(Pt 2):647–54.

    PubMed  Google Scholar 

  20. Wagner JC, Hill RJ, Berry G, Wagner MM. Treatments affecting the rate of asbestos-induced mesotheliomas. Br J Cancer. 1980;41(6):918–22.

    Article  CAS  Google Scholar 

  21. Wehner AP, Zwicker GM, Cannon WC. Inhalation of talc baby powder by hamsters. Food Cosmet Toxicol. 1977;15(2):121–9.

    Article  CAS  Google Scholar 

  22. Wehner AP. Cosmetic talc should not be listed as a carcinogen: comments on NTP's deliberations to list talc as a carcinogen. Regul Toxicol Pharmacol. 2002;36(1):40–50.

    Article  CAS  Google Scholar 

  23. World Health Organization (WHO) IARC Monograph. Carbon black, titanium dioxide, and talc. Working Group on the Evaluation of Carcinogenic Risks to Humans. 2010.

  24. Boorman GA, Seely JC. The lack of an ovarian effect of lifetime talc exposure in F344/N rats and B6C3F1 mice. Regul Toxicol Pharmacol. 1995;21(2):242–3.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, 89 Beaumont Avenue, Given C222, Burlington, VT, 05405, USA

    Brooke T. Mossman

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  1. Brooke T. Mossman
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Correspondence to Brooke T. Mossman.

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Conflicts of Interest

Dr. Mossman has performed research that has been funded by the National Institutes of Health and other foundations on mineral dusts and disease for over 40 years. These include studies on talcs (1982–2010) that have been used as negative controls in her experiments. Since 2015, Dr. Mossman has testified for defendants in talc litigation, including Johnson and Johnson, Inc. Dr. Mossman has received no remuneration for her time and scientific opinions expressed here.

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Mossman, B.T. Letter to the Editor: Fletcher NM, Harper AK, Memaj I, Fan R, Morris RT, Saed GM. Molecular Basis Supporting the Association of Talcum Powder Use with Increased Risk of Ovarian Cancer. Reprod Sci. 2019;26(12):1603–12. DOI: 10.1177/1933719119831773. Reprod. Sci. 27, 1834–1835 (2020). https://doi.org/10.1007/s43032-020-00265-9

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  • DOI: https://doi.org/10.1007/s43032-020-00265-9