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Preoperative Circulating Lymphocyte and Monocyte Counts Correlate with Patient Outcomes in Type I and Type II Endometrial Cancer

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Abstract

Tumor-associated macrophages and tumor-infiltrating lymphocytes are associated with survival in solid malignancies. Given the physiological link to peripheral immune cell counts, we evaluated if peripheral immune cell counts were predictors of outcomes in endometrial cancer. A retrospective study was completed for endometrial cancer cases between 2000 and 2010. Kaplan-Meier, bivariate, and multivariable Cox proportion hazard analyses were performed examining the relations between survival and peripheral immune cell counts. Three hundred ten patients were identified. In bivariate analyses, high monocyte counts (> 0.7 × 109 cells/L) trended with decreased progression free survival (PFS) (p = 0.10) and poorer overall survival (OS) (p = 0.16). By contrast, high lymphocyte level (> 1.5 × 109 cells/L) was associated with improved PFS (p = 0.008) and OS (p = 0.006). These findings were consistent for type I and type II endometrial cancers. In a multivariable Cox model, high monocyte level was associated with a greater risk of disease recurrence (hazard ratio (HR) = 1.63, p < 0.035). Other significant predictors of recurrence were age, non-endometrioid histology, and the presence of lymph vascular space invasion (LVSI). In a multivariable Cox model, high lymphocyte count trended with a lower risk of death (HR = 0.66, p = 0.07). Age, surgical stage, non-endometrioid histology, and LVSI were also associated with death in this model. In this sample of endometrial cancer patients, we found that high preoperative lymphocyte counts were associated with improved overall improved survival. High monocyte counts were associated with poorer disease-free survival outcomes. Further studies that focused on understanding tumor-antagonizing and pro-tumoral effects of lymphocytes and monocytes, respectively, in endometrial cancer are recommended.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, University of Kentucky College of Medicine, Lexington, KY, 40536, USA

    Brian Burgess

  2. Department of Social Sciences and Health Policy, Wake Forest University Comprehensive Cancer Center, Winston-Salem, NC, 27157, USA

    Beverly Levine

  3. Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, UT, 84132, USA

    Robert N. Taylor

  4. Department of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA

    Michael G. Kelly

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  1. Brian Burgess
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  2. Beverly Levine
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  4. Michael G. Kelly
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Correspondence to Michael G. Kelly.

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Burgess, B., Levine, B., Taylor, R.N. et al. Preoperative Circulating Lymphocyte and Monocyte Counts Correlate with Patient Outcomes in Type I and Type II Endometrial Cancer. Reprod. Sci. 27, 194–203 (2020). https://doi.org/10.1007/s43032-019-00009-4

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  • DOI: https://doi.org/10.1007/s43032-019-00009-4

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