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Multifaceted role of TRIM21 in inflammation

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Abstract

Tripartite motif (TRIM) family members participate in a variety of cellular activities, such as intracellular signaling, development, cellular death, protein quality control, immunological defense, waste degradation, and the emergence of cancer. These proteins usually act as E3 ubiquitin ligase. The final line of resistance against infectious viruses is a cytosolic ubiquitin ligase and antibody receptor called TRIM containing 21. TRIM21, a protein with a tripartite structure, has been linked to autoimmune erythematosus, Sjogren’s disorder, and innate immunity. TRIM21 may either promote the formation of specific cancer-activating proteins, resulting in their proteasomal degradation, or it may do neither, depending on the kind of cancer and cancer-causing trigger. The current research has shown that the antiviral action of TRIM mostly depends on their role as E3-ubiquitin ligases and a significant portion of the TRIM family mediates the transmission of innate immune cell signals and the subsequent production of cytokines. We highlighted the function of TRIM family members in various inflammatory diseases.

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Acknowledgements

The authors are thankful for all those who provided assistance in publication.

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  1. Sana Tanveer, Ali Afzal and Zaman Gul have contributed equally to this study.

Authors and Affiliations

  1. Applied Molecular Biology and Biomedicine Lab, Department of Zoology, University of Narowal, Narowal, Pakistan

    Sana Tanveer, Amara Noureen & Muhammad Babar Khawar

  2. Shenzhen Institute of Advanced Technology, University of Chinese Academy of Sciences, Shenzhen, Guangdong, China

    Ali Afzal

  3. Molecular Medicine and Cancer Therapeutics Lab, Department of Zoology, Faculty of Sciences & Technology, University of Central Punjab, Lahore, Pakistan

    Ali Afzal & Hanan Afzal

  4. Institute of Zoology, The University of Punjab, Lahore, Pakistan

    Zaman Gul

  5. Department of Pharmacy, University of Lahore, Lahore, Pakistan

    Muhammad Sharif

  6. Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu, China

    Muhammad Babar Khawar

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ST, AA and MBK searched the literature and wrote the initial draft. ZG and MS revised the initial draft. HA contributed to the study conception and design and edited the final draft. MBK and AA supervised the work and approved the final manuscript. All authors read and approved the final manuscript.

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Correspondence to Muhammad Babar Khawar.

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Tanveer, S., Afzal, A., Gul, Z. et al. Multifaceted role of TRIM21 in inflammation. BIOLOGIA FUTURA (2024). https://doi.org/10.1007/s42977-024-00221-7

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