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Design, synthesis and biological studies of tetrazole fused imidazopyridines

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New tetrazole fused imidazopyridine derivatives (12a–j) were developed to exploit their cytotoxic activity towards cancer cell lines-MCF7, A549, and MDA-MB-231, utilizing MTT reduction assay with doxorubicin as standard drug. The compounds 12 h and 12j demonstrated strong anticancer activity bearing IC50 values 1.44 µM and 1.33 µM against A549 cell line.

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Correspondence to Mandava V. Basaveswara Rao.

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Reddy, B., Taneja, A.K., Tej, M.B. et al. Design, synthesis and biological studies of tetrazole fused imidazopyridines. Carbon Lett. 34, 41–49 (2024).

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