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Design, synthesis and biological studies of tetrazole fused imidazopyridines

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Abstract

New tetrazole fused imidazopyridine derivatives (12a–j) were developed to exploit their cytotoxic activity towards cancer cell lines-MCF7, A549, and MDA-MB-231, utilizing MTT reduction assay with doxorubicin as standard drug. The compounds 12 h and 12j demonstrated strong anticancer activity bearing IC50 values 1.44 µM and 1.33 µM against A549 cell line.

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Authors and Affiliations

  1. Department of Chemistry, Krishna University, Machilipatnam, Andhra Pradesh, 521003, India

    Banoth Reddy & Mandava V. Basaveswara Rao

  2. Department of Chemistry, Chaudhary Charan Singh University, Meerut, 250001, India

    Amit Kumar Taneja

  3. Department of Healthcare Informatics, Sacred Heart University, 5151 Park Avenue, Fair Fields, CT, 06825, USA

    Mandava Bhuvan Tej

  4. Department of MBBS, NRI Academy of Medical Sciences, Chinakakani, Guntur, Andhra Pradesh, 522503, India

    Komati Navya Sri & Mandava Bhagya Tej

  5. Department of Chemistry, Amrita Sai Institute of Science and Technology, Paritala, Andhra Pradesh, 521180, India

    Suryadevara Vijayavardhini

  6. Department of Chemistry, Dhanekula Institute of Engineering and Technology, Ganguru, Vijayawada, Andhra Pradesh, 521139, India

    Dandamudi Srilaxmi

  7. Department of Science & Humanities, St. Martin’s Engineering College, Dhulapally, Hyderabad, Telangana, 500100, India

    Somasekhar Tiruveedhula

  8. Department of Chemistry, Case Western Reserve University, Cleveland, USA

    Srinivasa Rao Penumutchu

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  1. Banoth Reddy
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Reddy, B., Taneja, A.K., Tej, M.B. et al. Design, synthesis and biological studies of tetrazole fused imidazopyridines. Carbon Lett. 34, 41–49 (2024). https://doi.org/10.1007/s42823-023-00603-2

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  • DOI: https://doi.org/10.1007/s42823-023-00603-2

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