Abstract
Purpose
The spray-type adhesion barrier “AdSpray®” can be easily used even in a small abdominal cavity. However, there have been no reports on the safety and efficacy of its application in children. We retrospectively examined the safety and efficacy of AdSpray® in pediatric laparoscopic surgery.
Methods
We performed a retrospective review of all patients < 18 years old for whom AdSpray® was used in laparoscopic surgery at our institution between September 2017 and December 2021. As postoperative adverse events, intra-abdominal abscess, peritonitis and wound infection were evaluated. The morbidity of ileus during the postoperative follow-up period was also evaluated. Liver enzymes and the renal function before and after surgery were analyzed.
Results
A total of 64 children underwent laparoscopic surgery and simultaneous AdSpray® treatment. There were 48 children < 6 years old. There were no allergic symptoms or inflammatory reactions, liver dysfunction or renal dysfunction during and the stable period after surgery. Three patients with adhesive ileus who underwent laparoscopic surgery using AdSpray® did not show recurrent ileus in over three year of clinical follow-up.
Conclusion
This study investigated the safety and efficacy of AdSpray® in pediatric laparoscopic surgery, and no adverse events associated with AdSpray® usage were confirmed.
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Availability of data and materials
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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Acknowledgements
We appreciate Mr. Brian Quinn for his advices and help with the manuscript.
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The authors did not receive support from any organization for the submitted work.
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Contributions
MM and KS drafted the manuscript and equally contributed to this study. SI and TK supervised the writing of the manuscript. YI, MO, LT, NN, AN, KY, SO, TH, KY WY, MM, TK and MM performed surgery and perioperative management of the patient. All authors read and approved the final manuscript.
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Ethics approval and consent to participate
This study was performed in accordance with the Ethical Guidelines for Medical and Health Research Involving Human Subjects by the Ministry of Health, Labour, and Welfare of Japan in 2014. The study complied with the 1964 Declaration of Helsinki (revised in 2013) and was approved by the local ethics committee of Kagoshima University Hospital (registration number: 27-119). All participants, or their parents, provided their informed consent for inclusion for publication of this article and any companying images.
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Murakami, M., Sugita, K., Iwamoto, Y. et al. Safety of the spray-type adhesion barrier “AdSpray®”in pediatric laparoscopic surgery. J Ped Endosc Surg (2024). https://doi.org/10.1007/s42804-024-00226-y
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DOI: https://doi.org/10.1007/s42804-024-00226-y