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Comparative pathogenicity of Scedosporium species in murine model of systemic scedosporiosis

  • Bacterial and Fungal Pathogenesis - Research Paper
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Abstract

Systemic scedosporiosis is a devastating emerging fungal infection caused by several species of the genus Scedosporium in immunocompetent and immunocompromised individuals. In this study, we compared the virulence of different Scedosporium species in a murine model of systemic scedosporiosis by survival assays, fungal burden and histopathological analysis. We found that mice mortality was species-dependent, S. apiospermum, S. aurantiacum and S. dehoogii were the most virulent species. We also observed the dissemination and invasion of Scedosporium species to the brain, spleen and kidney by colony count and histopathological analysis at different times of infection. Particularly, the brain was the tissue most susceptible to invasion during systemic scedosporiosis. This study shows the virulence and pathophysiology of different Scedosporium species and will be useful in facilitating control and prevention strategies for systemic scedosporiosis.

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Acknowledgements

This research was made possible through support from Conacyt-INFRA-2015-01.

Funding

This work was supported by the Consejo Nacional de Ciencia y Tecnología [CONACyT-INFRA-2015–01-251142].

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Author notes

  1. Mariana Elizondo-Zertuche and Orlando Flores-Maldonado contributed equally and share the first author position.

Authors and Affiliations

  1. Departamento de Microbiología, Universidad Autónoma de Nuevo León, Facultad de Medicina Y Hospital Universitario “Dr. José Eleuterio González”, Av. Francisco I. Madero, Mitras Centro, Monterrey, 64460, México

    Mariana Elizondo-Zertuche, Orlando Flores-Maldonado, Gloria M. González & Miguel Becerril-Garcia

Authors
  1. Mariana Elizondo-Zertuche
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  2. Orlando Flores-Maldonado
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  3. Gloria M. González
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  4. Miguel Becerril-Garcia
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Contributions

Elizondo-Zertuche: Conceptualization, Methodology, Formal analysis, Investigation. Flores-Maldonado: Formal analysis, Visualization, Writing-original draft, Writing-review & editing. Gonzalez G: Conceptualization, Methodology, Validation, Resources, Supervision, Project administration, Funding acquisition. Becerril-Garcia: Formal analysis, Visualization, Investigation, Writing-original draft, Writing-review & editing.

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Correspondence to Miguel Becerril-Garcia.

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Supplementary Information

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42770_2023_1065_MOESM1_ESM.docx

Additional file 1: Supplementary Table 1. Survival rates of ICR mice infected intravenously with different Scedosporium species. (DOCX 17 KB)

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Elizondo-Zertuche, M., Flores-Maldonado, O., González, G.M. et al. Comparative pathogenicity of Scedosporium species in murine model of systemic scedosporiosis. Braz J Microbiol 54, 1335–1340 (2023). https://doi.org/10.1007/s42770-023-01065-4

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  • DOI: https://doi.org/10.1007/s42770-023-01065-4

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