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Comparative antimicrobial activity of four different endodontic sealers

  • Clinical Microbiology - Short Communication
  • Published:
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Abstract

Dental cements are widely used in the clinical routine, specifically for root canal sealing. Within this context, it is expected that these materials present antimicrobial activity, since it would help in the prevention of apical and periapical infections. The present study aimed to comparatively verify the antimicrobial activity of four dental cements against microorganisms that are routinely isolated from endodontic infections. Reference strains of Enterococcus faecalis, Candida albicans and Escherichia coli were submitted to the agar diffusion test and to modified direct contact test using four different sealers: an eugenol zinc oxide compound, an epoxy resin associated to calcium hydroxide and bismuth, a mineral trioxide aggregate (MTA) and a bioceramics. Different E. coli, C. albicans and E. faecalis growth inhibition profiles were observed in the agar diffusion assay. In the direct contact test, the bioceramics presented a higher microbicide activity on all microorganisms tested herein. Dental cements have different antimicrobial activities, being that the bioceramics present the most consistent antimicrobial activity, and that the direct contact test presented more uniform results than the agar diffusion test. This study reveals the antimicrobial activities of different cements and allow dentists to decide which material to employ in their daily practice.

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Fig. 1

Data availability

The data that support the findings of this study are available on request from the corresponding author, RDP.

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Acknowledgements

The authors are grateful to Francisca Soares (LABIMUNO-UFBA) for technical assistance.

Funding

This work was supported by the Fundação de Apoio à Pesquisa e Extensão (FAPEX), through continuous resources obtained from extension projects. RDP is a Technical Development fellow from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPQ—Proc. 310058/2022-8).

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Authors and Affiliations

  1. Laboratory of Oral Biochemistry, Health Sciences Institute, Federal University of Bahia, Salvador, BA, 40110-100, Brazil

    Ana Rita Sokolonski, Sérgio Ricardo Almeida & Danilo Barral Araújo

  2. Laboratory of Immunology and Molecular Biology, Health Sciences Institute, Federal University of Bahia, Salvador, BA, 40110-100, Brazil

    Carolina Ferreira Amorim, Luiz Eduardo Lacerda, Roberto Meyer & Ricardo Dias Portela

Authors
  1. Ana Rita Sokolonski
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  2. Carolina Ferreira Amorim
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  3. Sérgio Ricardo Almeida
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  4. Luiz Eduardo Lacerda
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  5. Danilo Barral Araújo
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  6. Roberto Meyer
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  7. Ricardo Dias Portela
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Contributions

ARS, CFA and LEL conducted the experimental work. ARS and SEA wrote the manuscript. DBA and RDP critically reviewed the manuscript. RM and RDP supervised the project. All authors read and approved the final version of the manuscript.

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Correspondence to Ricardo Dias Portela.

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The authors declare no competing interests.

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Sokolonski, A.R., Amorim, C.F., Almeida, S.R. et al. Comparative antimicrobial activity of four different endodontic sealers. Braz J Microbiol 54, 1717–1721 (2023). https://doi.org/10.1007/s42770-023-01003-4

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  • DOI: https://doi.org/10.1007/s42770-023-01003-4

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