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Bactericidal activity of silver nanoparticles in drug-resistant bacteria

  • Bacterial, Fungal and Virus Molecular Biology - Review
  • Published:
Brazilian Journal of Microbiology Aims and scope Submit manuscript

Abstract

Bacterial resistance to multiple drugs is a worldwide problem that afflicts public health. Various studies have shown that silver nanoparticles are good bactericidal agents against bacteria due to the adherence and penetration of the external bacterial membrane, preventing different vital functions and subsequently bacterial cell death. A systematic review of ScienceDirect, PubMed, and EBSCOhost was conducted to synthesize the literature evidence on the association between the bactericidal property of silver nanoparticles on both resistant Gram-positive and Gram-negative bacteria. Eligible studies were original, comparative observational studies that reported results on drug-resistant bacteria. Two independent reviewers extracted the relevant information. Out of the initial 1 420, 142 studies met the inclusion criteria and were included to form the basis of the analysis. Full-text screening led to the selection of 6 articles for review. The results of this systematic review showed that silver nanoparticles act primarily as bacteriostatic agents and subsequently as bactericides, both in Gram-positive and Gram-negative drug-resistant bacteria.

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Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

The authors thank the NANOMEDICINA-UACJ research group for their constant support and feedback at all stages of this research

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Authors and Affiliations

  1. Grupo de Investigación en Nanomedicina, Instituto de Ingeniería y Tecnología de la Universidad Autónoma de Ciudad Juárez, Ave. del Charro 450, Ciudad Juárez, 32310, México

    C. Chapa González & L. I. González García

  2. Ingeniería Biomédica, Instituto de Ingeniería y Tecnología de la Universidad Autónoma de Ciudad Juárez, Ave. del Charro 450, Ciudad Juárez, 32310, México

    C. Chapa González, L. G. Burciaga Jurado & A. Carrillo Castillo

  3. Biotecnología y Nanotecnología en Electrónica Flexible, Instituto de Ingeniería y Tecnología de la Universidad Autónoma de Ciudad Juárez, Ave. del Charro 450, Ciudad Juárez, 32310, México

    A. Carrillo Castillo

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  1. C. Chapa González
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Chapa González, C., González García, L.I., Burciaga Jurado, L.G. et al. Bactericidal activity of silver nanoparticles in drug-resistant bacteria. Braz J Microbiol 54, 691–701 (2023). https://doi.org/10.1007/s42770-023-00991-7

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  • DOI: https://doi.org/10.1007/s42770-023-00991-7

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