Abstract
Fungal sinusitis is a widespread infection that affects both healthy and immunocompromised individuals. Reports of sinus fungal infections have increased due to recent advances in diagnosis. Furthermore, susceptible and immune-compromised patients play an important role in increasing the number of reported cases. Infections with lesser-known fungi have been reported infrequently around the world. This paper describes a Cladosporium tenuissimum infection caused by chronic fungal sinusitis in a woman who had traveled to several countries. We used morphological and molecular methods to confirm the infection. The infection is most likely caused by the use of sulfasalazine, which is related to the patient’s rheumatism. Sulfasalazine inhibits neutrophilic chemoattractant lipid synthesis in neutrophils, which play a key role in antifungal immunity. The patient is also undergoing root canal therapy and has several upper jaw implants, which may have contributed to the development of sinusitis.
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References
Swami T et al (2016) Chronic invasive fungal rhinosinusitis by Paecilomyces variotii: a rare case report. Indian J Med Microbiol 34(1)
Alotaibi NH et al (2020) Chronic invasive fungal rhinosinusitis in immunocompetent patients: a retrospective chart review. Front Surg 7:608342
Mensi M et al (2007) Risk of maxillary fungus ball in patients with endodontic treatment on maxillary teeth: a case-control study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103(3):433–436
Chatterjee SS, Chakrabarti A (2009) Epidemiology and medical mycology of fungal rhinosinusitis. Otorhinolaryngol Clin Int J 1(1):1–13
Greval R et al (1990) Incidence of fungal infections in chronic maxillary sinusitis. Indian J Pathol Microbiol 33(4):339–343
Sood N, Makkar R (2000) Case report. Subcutaneous phaeohyphomycosis due to Cladosporium cladosporioides. Mycoses 43(1-2):85–87
Chakrabarti A et al (2015) Epidemiology of chronic fungal rhinosinusitis in rural India. Mycoses 58(5):294–302
Buzina W et al (2003) Fungal biodiversity–as found in nasal mucus. Med Mycol 41(2):149–161
Chakrabarti A et al (2009) Fungal rhinosinusitis: a categorization and definitional schema addressing current controversies. Laryngoscope 119(9):1809–1818
Deutsch PG, Whittaker J, Prasad S (2019) Invasive and non-invasive fungal rhinosinusitis—a review and update of the evidence. Medicina 55(7):319
Watkinson JC, Clarke RW (2018) Scott-Brown's otorhinolaryngology and head and neck surgery: volume 1. In: basic sciences, endocrine surgery, rhinology. CRC Press
Dufour X et al (2006) Paranasal sinus fungus ball: epidemiology, clinical features and diagnosis. A retrospective analysis of 173 cases from a single medical center in France, 1989–2002. Sabouraudia 44(1):61–67
Dhong H-J, Jung J-Y, Park JH (2000) Diagnostic accuracy in sinus fungus balls: CT scan and operative findings. Am J Rhinol 14(4):227–232
Montone KT (2016) Pathology of fungal rhinosinusitis: a review. Head Neck Pathol 10(1):40–46
Seyedmousavi S et al (2011) Exophiala sideris, a novel black yeast isolated from environments polluted with toxic alkyl benzenes and arsenic. Fungal Biol 115(10):1030–1037
Bensch K et al (2012) The Genus Clad Stud Mycol 72:1–401
White TJ et al (1990) Amplification and direct sequencing of fungal ribosomal RNA genes for phylogenetics. PCR Protoc: Guide To Methods Appl 18(1):315–322
Kočí M (2012) Synthesis and in vitro evaluation of bispyridinium type acetylcholinesterase inhibitors. [Pharmacy]
Basiri Jahromi S, Khaksar A, Iravani K (2002) Phaeohyphomycosis of the sinuses and chest by cladosporium bantianum. Med J The Islamic Republic of Iran (MJIRI) 16(1):55–58
Symersky T et al (2004) Faecal elastase-I: helpful in analysing steatorrhoea. Neth J Med 62(8):286–289
Alroqi A (2021) A case report of rare fungal pathogens causing recurrent allergic fungal rhinosinusitis and literature review. Sci Prog 104(4):00368504211053512
DeShazo RD, Chapin K, Swain RE (1997) Fungal sinusitis. N Engl J Med 337(4):254–259
Veress B et al (1973) Further observations on the primary paranasal aspergillus granuloma in the Sudan: a morphological study of 46 cases. The American J Trop Med Hyg 22(6):765–772
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Abozar Nasiri Jahrodi: study design, sample preparation, first draft preparation.
Fateme-Maryam Sheikholeslami: molecular investigation.
Mehdi Barati: manuscript revision and image preparing.
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Nasiri-Jahrodi, A., Sheikholeslami, FM. & Barati, M. Cladosporium tenuissimum-induced sinusitis in a woman with immune-deficiency disorder. Braz J Microbiol 54, 637–643 (2023). https://doi.org/10.1007/s42770-023-00978-4
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DOI: https://doi.org/10.1007/s42770-023-00978-4