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Spread of multidrug-resistant Acinetobacter baumannii isolates belonging to IC1 and IC5 major clones in Rondônia state

  • Clinical Microbiology - Short Communication
  • Published:
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Abstract

In Brazil, carbapenem-resistant A. baumannii (CRAB) is a critical pathogen showing high carbapenem resistance rates. Currently, there is little epidemiological data on A. baumannii isolated in the Northern Brazilian region. Herein, this study aimed to characterize the resistance mechanisms of CRAB isolates recovered from hospitalized patients in the state of Rondônia in 2019. Most of CRAB were considered as extensively drug-resistant, and some of them showed high MICs for minocycline. Only polymyxins showed a satisfactory activity. All isolates carried blaOXA-23 and were included in 14 distinct clusters, with the predominance of clonal group A (29%). The IC1 was the most frequent clonal group, followed by IC5 and IC4. Here, we firstly reported the epidemiological scenario of CRAB in the state of Rondônia, located in the Brazilian Amazon region. The high frequency of CRAB presenting XDR phenotype is of great concern, due to limited therapeutical options, especially in the actual pandemic scenario, in which we observed an overcrowding of ICU beds. Such results are essential to better characterize the epidemiology of CRAB in the entire Brazilian territory.

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Funding

We are grateful to Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) for providing grants to T.B.V., C.S.N., and F.F.S. (PNPD), and to the National Council for Science and Technological Development (CNPq) for providing grant to A.C.G. (Process number: 312066/2019).

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Author notes

  1. Tiago Barcelos Valiatti

    Present address: Laboratório Alerta, Division of Infectious Diseases, Department of Internal Medicine. Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), Rua Pedro de Toledo, 781, 6th floor, Vila Clementino, São Paulo, SP, 04039-032, Brazil

Authors and Affiliations

  1. Laboratório Alerta, Division of Infectious Diseases, Department of Internal Medicine. Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), Rua Pedro de Toledo, 781, 6th floor, Vila Clementino, São Paulo, SP, 04039-032, Brazil

    Fernanda Fernandes Santos, Carolina Silva Nodari, Rodrigo Cayô, Juliana Thalita Paulino da Silva & Ana Cristina Gales

  2. Hospital de Base Dr. Ary Pinheiro, Porto Velho, RO, Brazil

    Tatiane Silva Carvalho

  3. Laboratório de Imunologia e Bacteriologia (LIB), Setor de Biologia Molecular, Microbiologia e Imunologia, Departamento de Ciências Biológicas (DCB), Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF), Universidade Federal de São Paulo (UNIFESP), Diadema, SP, Brazil

    Rodrigo Cayô

  4. Laboratório Central de Saúde Pública de Rondônia (LACEN-RO), Porto Velho, RO, Brazil

    Cicileia Correia da Silva, Jacqueline Andrade Ferreira, Lorena Brandhuber Moura & Levy Assis dos Santos

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  1. Tiago Barcelos Valiatti
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Corresponding author

Correspondence to Tiago Barcelos Valiatti.

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Conflict of interest

A.C.G. has recently received research funding and/or consultation fees from bioMérieux Eurofarma, MSD, Pfizer, Sandoz, United Medical and Zambon. Other authors have nothing to declare. This study was not financially supported by any Diagnostic/Pharmaceutical company.

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Barcelos Valiatti, T., Silva Carvalho, T., Fernandes Santos, F. et al. Spread of multidrug-resistant Acinetobacter baumannii isolates belonging to IC1 and IC5 major clones in Rondônia state. Braz J Microbiol 53, 795–799 (2022). https://doi.org/10.1007/s42770-022-00706-4

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